Luo Jing, the host of the famous News Network, Cindy Lee, the actor who plays Fang Yu in Deep Rain, and Fuck off! Tumor jun touched many netizens’ cartoonist Xiong Dun … In recent years, many celebrities have passed away because of lymphoma. At the same time, however, there are also many famous people who have succeeded in fighting cancer after suffering from lymphoma. For example, the 70-year-old famous director Wu Yusen was diagnosed with large B-cell lymphoma in tonsils when filming Taiping Wheel in 2008. After four operations, in the second month of chemotherapy, his mouth was all festered, he could not swallow, and his body and face were so thin that he was wrinkled. Finally, he succeeded in fighting cancer with his firm will! 　

　 　 　 　For example, Kai-Fu Lee, the founder of an innovative factory that successfully used chemotherapy and targeted therapy to fight advanced lymphoma! On September 5, 2013, 52-year-old Kai-fu Lee announced that he had stage IV follicular lymphoma and had to leave work for treatment. In February 2015, he announced the results of his physical examination, indicating that the tumor in the body is not obvious at present. In June of the same year, Kai-fu Lee said that he had not found any lesions in his last two examinations and ridiculed himself as "Li Kangfu". It took Kai-fu Lee less than two years from finding out the cancer until the focus was completely gone. His anti-cancer experience is worth learning from.

Alias "the most disguised disease", lymphoma has become a killer.

　 　 　 　According to statistics, there is a new case of lymphoma every 9 minutes in the world. The incidence of lymphoma in China is 0.02‰, with about 25,000 new patients and nearly 20,000 deaths each year. The threat of lymphoma is rapidly emerging. It ranks among the top ten malignant tumors in China and ranks second among hematological malignancies. At the beginning, the symptoms of the disease were hidden, and it was described as "the most disguised disease". In the intercontinental area, the incidence of non-Hodgkin’s lymphoma is much higher than Hodgkin’s disease, which is about 9: 1. Because of the higher degree of malignancy and worse prognosis, lymphoma is generally referred to as non-Hodgkin’s lymphoma. In China, the incidence of malignant tumors ranks ninth among men and tenth among women. Non-Hodgkin’s lymphoma can occur in all ages, and the high incidence age is 45~60 years old. Among them, Luo Jing suffered from diffuse large B-cell lymphoma (DLBCL). This is a common non-Hodgkin’s lymphoma, which belongs to aggressive lymphoma with high malignancy. The course of the disease progresses rapidly. If it is not actively treated, the median survival time is less than one year. In recent years, great progress has been made in the research and treatment of lymphoma, and new drugs and technologies have risen strongly! CAR-T therapy Among them, the chimeric antigen receptor T(CAR-T) cell therapy is particularly prominent. Its appearance represents a great progress in personalized cancer treatment, especially bringing the hope of rebirth to patients with hematological malignancies.

Complete remission! The first advanced lymphoma patient in China who received CAR-T therapy was discharged smoothly!

　 　 　 　Although they all suffer from diffuse large B-cell lymphoma, Mr. Chen, who suffers from malignant lymphoma, is a lucky one. According to Jiangsu public news channel News Space Station, on August 31st, the first lymphoma patient treated with CAR-T cells in China achieved complete remission and was discharged smoothly. 　

　 　 　 　Mr. Chen suffered from diffuse large B-cell lymphoma. After the onset of the disease in October 2010, he had received chemotherapy for many times, but all of them were unsatisfactory. Diffuse large B-cell lymphoma is the most common malignant lymphoma. After immunotherapy, about 60% patients can survive for a long time, but 40% patients will still relapse. In June this year, Mr. Chen accepted CAR-T cell therapy with a tentative attitude, and all the physical indicators tended to be normal. He told reporters with delight that his physical condition was better than before, and he was no different from a normal person after leaving the hospital. CAR-T therapy, a "living drug", made her completely relieved and looked forward to a cancer-free future.　

　 　 　 　As a "living" drug, CAR-T therapy is very different from traditional drugs. First, the therapy needs to isolate T cells from patients and modify them with chimeric antigen receptor (CAR) in vitro, so that they can specifically recognize cancer cells. Finally, the modified T cells are expanded and reinfused into patients. Compared with traditional chemotherapy and hematopoietic stem cell transplantation, it can kill tumor cells more accurately, improve the curative effect and greatly reduce the side effects. 　

The well-known director of hematology in China said: CAR-T can identify lymphoma very deliberately, and the antigen carried on tumor cells will attack directly after being connected, and it will produce an anti-tumor effect and kill it directly without the need for second signal stimulation, so one of its characteristics is accuracy, and the second is power. The scope of application is still the recurrence or refractory diffuse large B lymphoma that is ineffective in general immunochemotherapy. 　

CAR-T therapy FDA approved 6 models, and domestic CAR-T therapy caught up! 　　　

　 　 　 　After sharing the above news reports about CAR-T therapy, let’s get down to business and talk about CAR-T therapy. At present,CAR-T therapy has achieved great success in the treatment of hematological malignancies.. Six CAR-T cell therapies have been approved by FDA in the United States and two CAR-T cell therapies have been listed in China. The picture below shows CAR-T cell therapy that has been listed at home and abroad. 　 　　

　 　 　 　Although China’s CAR-T technology started late, the domestic market is large. According to the data on Clinicaltrials.gov’s website, China became the country that registered the most CAR-T tests in September 2017. As of May 27th, 2021, there are 1301 CAR-T clinical trials in the world, and the number of CAR-T trials registered in China has reached 478!　

01　　The first CAR-T therapy in China was approved for listing! China welcomes the first year of cellular immunotherapy.

　 　 　 　On June 22nd, the blank in the field of CAR-T in China was finally broken! The latest announcement of China National Medical Products Administration (NMPA), Fosun Kaite Biotechnology Co., Ltd. (hereinafter referred to as " Fosun Kate ”） The CAR-T cell therapy product targeting CD19, Aquilencel Injection (also known as Aquilencel, FKC876), was officially approved for marketing. This is the first approved CAR-T therapy in China and the sixth approved CAR-T therapy in the world. It is believed that China will usher in the blowout era of CAR-T cell therapy.　

02　　In just one month, the second CAR-T therapy in China and the sixth CAR-T therapy in the world were approved!

　 　 　 　On September 3, the State Drug Administration recently announced that Yaoming JunuoThe CAR-T product targeting CD19, Regiosai Injection.(relma-cel, trade name: Benoda) has been officially approved. The approved indications for Regioside Injection are:It can be used to treat relapsed or refractory large B-cell lymphoma (r/r LBCL) in adult patients after second-line or above systemic treatment.Reggiorense injection is the second CAR-T product approved in China and the first CAR-T product of Class 1 biological products in China.

　

It’s only been about one month since it was submitted for examination and approval on July 30th last time, which can be described as rapid progress. Congratulations! (At present, patients with economic conditions can contact cancer-free homes for the treatment of regiorense. )　

Boom! The first BCMA CAR-T therapy in China and the second in the world was approved by FDA!

　 　 　 　China’s "dark horse" in CAR-T cell therapy industry-legendary BCMA(B-cell mature antigen) CAR-T therapy Cedar-B38m/JNJ-4528 (hereinafter referred to as cilta-cel) has attracted much attention, and has shown excellent anticancer activity in clinical trials for multiple myeloma.

　 　 　 　What is exciting is that on February 28th, 2022, local time, it was jointly developed by Janssen and Legendary Biology.BCMA CAR-T product, Cedactylosin (trade name Carvykti), has been approved by the US FDA for the treatment of adult patients with relapsed/refractory multiple myeloma (MM).

This is the first cell therapy product approved by FDA in China and the second CAR-T cell immunotherapy approved for BCMA in the world.

　

　 　 　 　Cilta-cel was awarded priority review qualification by FDA on May 26th.However, the approval of the West Dachiorensai was delayed, and it was adjusted from November 29, 2021 toFebruary 28, 2022Fortunately, it was finally approved and lived up to expectations!

　 　 　 　cilta-celIt is a CAR-T therapy directed by research B cell maturation antigen (BCMA), which is used to treat relapsed or refractory multiple myeloma (RRMM). These patients received an average of five kinds of pre-treatment before treatment, 76% of them received five kinds of treatment, and 86% of them were resistant to five kinds of treatment, including CD38 treatment, and they were both resistant to protease inhibitor PI and immunomodulator IMiD. Simply put, it is refractory to relapse and lack of effective treatment in the follow-up. The principle of this CAR-T therapy is different from the current PD-1/L1. It directly uses the T cells in the patient’s body, transforms them in vitro, replicates them in large quantities, and then transfuses them into the patient’s body to kill cancer cells. At the ASH conference in 2021, the latest results of the 1b/2 CARTITUDE-1 study (n=97) showed that,meso-position 22 months Long-term follow-up, The objective remission rate (ORR) reached 98% , 83% patients achieved strict complete remission (sCR) It is emphasized that the mitigation will deepen with the passage of time (sCR will increase from 67% reported at the ASH annual meeting in 2020 to 83%). At 18 months, 66% of the patients were alive and the disease did not progress. .The two-year progression-free survival rate and overall survival rate are respectively 61% and 74% .The latest research results to be announced at the ASCO annual meeting in 2021 show that After a median follow-up of 18 months, the overall survival (OS) rate was 81%. The remission rate is comparable in all pre-specified subgroups and patients with different treatment lines.

　　 　

American research shows that cilta-cel has excellent long-term efficacy.　 　

　 　 　 　Emily, a foreign country, successfully ushered in nine years of cancer-free survival in 2021, and suddenly became the "spokesperson" of global CAR-T therapy. In China, there is such a lucky person whose fate has been completely changed by CAR-T therapy. Mr. Min was diagnosed with a special rare disease at the age of 54- multiple myeloma . He had no drugs available at that time, so he was lucky enough to participate in the clinical trial of CAR-T therapy. Although the treatment process was not smooth sailing, after three times of treatment, all the lumps on Mr. Min’s body disappeared and the pain disappeared. Surprisingly, by June 4, 2021, Mr. Min had lived cancer-free for five years, which is the field of cancer treatment, which is theoretically said. Clinical cure .

　 　 　 　In fact, as early as March 27th this year,The FDA approved the first CAR-T therapy targeting BCMA for adult patients with relapsed/refractory multiple myeloma (r/r MM) after receiving more than four therapies.

　 　 　 　Chemotherapy to fight cancer is often "killing one thousand enemies and losing eight hundred". Antibody drugs can accurately find tumor targets, but sometimes their combat effectiveness is insufficient. If we can put a "warhead" of chemotherapy drugs on antibody drugs, can we attack cancer cells more accurately? Based on this, an ADC (antibody drug conjugate) called "biological missile" was born. Antibody-coupled drugs are like biological missiles, which consist of two core functions: the first is antibody (missile body), the second is strong chemotherapy drug (nuclear warhead); This design will enable antibodies to find tumor cells with chemotherapy drugs, and then accurately poison tumor cells and poison them. 　This drug design combines the precision of targeted drugs with the high efficiency of chemotherapy drugs, which not only avoids the toxic and side effects of systemic use of chemotherapy drugs, but also has stronger killing ability than using targeted drugs alone, killing two birds with one stone. 　 　 　 　

Schematic diagram of antibody-coupled drugs 　 Note: (a) General description of A)ADC structure; (b) the mechanism of B)ADC. 　

Fourteen ADC drugs have been approved around the world, which brings hope for prolonging the survival time of back-line patients.

　 　 　 　At present, more than 100 kinds of ADC are undergoing clinical trials. Most adcs have progressed from phase i to phase II. Some ADC phase III trials show positive results; Up to September 20th, 2021, there are 14 kinds of ADC drugs on the market in the world, which are mainly used in hematological tumors and solid tumors, and are mainly used for back-line treatment of patients, including advanced, recurrent/refractory and metastatic tumor indications.

　

Fourteen ADC drugs have been approved worldwide.

According to the curative effect data, ADC drugs have brought more treatment options and the hope of prolonging the survival time for back-line patients, and the objective remission rate or median progression-free survival time of several drugs has doubled compared with chemotherapy.

Looking at the CD30 target, the new drug F0002-ADC became an instant hit and squeezed into the lymphoma track.

　 　 　 　CD30, a member of tumor necrosis factor (TNF) receptor superfamily, can promote cell proliferation or apoptosis by activating different signal pathways. In 2020, Vebtuximab for injection (Adcetris) was approved to be listed in China, and CD30 became famous. Adcetris, as an antibody-coupled drug targeting CD30, has an effective rate of 73% for Hodgkin’s lymphoma (HL) and 86% for anaplastic large cell lymphoma (ALCL). It is the first new drug approved in the field of Hodgkin’s lymphoma treatment in recent 30 years, and it is also the first time that a drug targeting CD30 has been approved, filling the gap in this field. At present, the only new ADC drug for CD30 in China is F0002-ADC. This new drug consists of three parts, namely, human-mouse chimeric anti-CD30 monoclonal antibody, thioether linker (MCC) and DM1. Since the project was launched in 2016, it has been disappointing! At present, patients with recurrent/refractory CD30 positive peripheral T-cell lymphoma are being recruited clinically! This is a new treatment option for patients with recurrent/refractory peripheral T-cell lymphoma!

This article is original for a cancer-free home, and it needs authorization to reprint! Cancer-free homes remind patients 　

On October 24th, after the incident of eyebrow pencil in 79 yuan, the live broadcast room in Li Jiaqi broadcasted Huaxizi with goods again after 43 days. However, Li Jiaqi himself did not appear to explain the product of Huaxizi, and the controversial ace product Huaxizi eyebrow pencil did not appear in the live broadcast list. According to Time Finance, Hua Xizi’s performance in the live broadcast room in Li Jiaqi is still good, but compared with last year, it is much worse.

I and the disputed eyebrow pencil did not appear.

In the list of products with goods in Li Jiaqi Live Studio, there are three products owned by Hua Xizi, namely, a combination suit of 357 yuan, a powder cake of 149 yuan and honey powder of 129 yuan. According to Time Finance, at 8 pm, the live broadcast room in Li Jiaqi exceeded 10 million people. After the countdown was displayed on the screen, the gongs and drums in Li Jiaqi’s hand were sounded, and the pre-sale of Tmall "double 11" officially kicked off this year.

As soon as the live broadcast was started, more than 7,000 pieces, 3,000 pieces and 300 groups of Huaxizi air honey powder, Yurong gauze powder cake and water hibiscus in the Li Jiaqi live broadcast room had been booked respectively. At 8: 02, more than 20,000 pieces, 9,000 pieces and 1,000 pieces of three groups of products were ordered respectively. The figures will change every few minutes. By 10: 30 pm, the pre-sales of the above three groups of products exceeded 70,000, 3,000 and 30,000 respectively. According to Red Net, as of 11: 30 p.m. on 24th, the amount of honey powder with a price of 129 yuan for Huaxizi has exceeded 80,000 orders, the amount of powder cake with a price of 149 yuan has exceeded 30,000 orders, and the combined set with a price of 357 yuan has exceeded 3,000 orders, totaling more than 110,000 orders.

Although Hua Xizi’s performance in the live broadcast room in Li Jiaqi is still good, compared with last year, it is much worse. According to previous media reports, at 9: 00 pm on October 24th, 2022, the colored powder cake of Huaxizi Yurongsha was first released in the live broadcast room in Li Jiaqi. After only 15 minutes on the shelves, 250,000 colored powder cakes were sold out. According to Time Finance’s analysis, in addition to the previous storm, the sales volume of Hua Xizi was affected, and this sales performance may be related to the fact that Hua Xizi did not appear in the prime time of the live broadcast room in Li Jiaqi this year. According to Red Net, as of 11: 30 pm on the 24th, the number of viewers in the live broadcast room in Li Jiaqi was still at 10 million+.

The controversial ace product Hua Xizi eyebrow pencil did not appear in the live broadcast list. According to Time Finance, in the live broadcast room of Huaxi’s official flagship store, the anchor said that the eyebrow pencil "double 11" activity had not been announced. In the live commentary area, some netizens said bluntly: "I will never buy it again, which is really sad" and "How dare he"; However, some netizens said: "Although I am not interested in Hua Xizi, I am still interested in the things in the live broadcast room in Li Jiaqi."

Hua Xizi deeply binds Li Jiaqi.

Earlier, on September 10th, when Li Jiaqi introduced a Huaxizi Eyebrow Pencil in 79 yuan, he saw a message from a netizen saying it was expensive, and replied that 79 yuan Eyebrow Pencil could not be bought because he didn’t work hard enough. At the same time, it was exposed that 79 yuan Eyebrow Pencil was only 0.08 grams more expensive than gold, which led the netizens to think that Li Jiaqi despised ordinary people, created anxiety and inflated commodity prices.

In the early morning of September 11th, Li Jiaqi posted a blog post apologizing, and released an apology video on the evening of the same day, saying that his inappropriate remarks disappointed everyone, and he would also reflect on why he started in the first place and how he could serve more girls. Thank you again for your criticism and supervision. However, many netizens said that they "don’t buy it" for Li Jiaqi’s apology, and joked "Where ‘ Li ’ Wrong? " According to Xinmin Evening News, before the eyebrow pencil incident in 79 yuan, the number of fans in Weibo, Li Jiaqi was 30.435 million. By 11: 00 on October 24th, the number of fans was 28.747 million, and the number of fans dropped by over 1.68 million.

According to the International Finance News, four years ago, Hua Xizi announced Li Jiaqi as the chief recommender of the brand. At that time, this little-known brand was established only two years ago. With the help of the flow of "lipstick brother", the sales of Huaxizi reached 1.13 billion yuan that year, which was 25 times higher than that of 2018. The deep binding between the two parties began in 2019. According to the magic mirror data, the sales of Huaxizi’s star product, carved lipstick, increased by 165% month-on-month after it was promoted by Li Jiaqi multi-platform in May of that year. On the battlefield of "double 11", Hua Xizi never missed the live studio in Li Jiaqi from the pre-sale stage, and with the help of Li Jiaqi’s strong ability to carry goods, he won 220 million yuan GMV for the first time in the war and became the second place in domestic beauty cosmetics.

Around the "double 11" in that year, the live broadcast room in Li Jiaqi contributed 64% of the total turnover of Huaxizi. In June, 2022, Li Jiaqi stopped broadcasting for some reason. During the "June 18th Promotion" period, the sales of Huaxizi, who lost Li Jiaqi, dropped to 150 million yuan from 263 million yuan in the previous year. According to shanghai securities news, the founder of Huaxizi once said in public that their cooperation with Li Jiaqi is Live Delivery 2.0, that is, inviting anchors to create products together. Some insiders revealed: "As long as this product Li Jiaqi says no, it will not pass."

After the eyebrow pencil dispute, Li Jiaqi gradually withdrew

Although Li Jiaqi still has a long way to go to quell doubts and rebuild trust, compared with Hua Xizi who was involved in the storm by his inappropriate remarks, as the starting point of the storm, he seems to have gradually withdrawn from the continuous controversy.

According to previous poster news reports, on September 26th, Li Jiaqi was carrying goods live on Taobao on the night when Hua Xizi’s crazy public relations sparked heated discussion. At the beginning of the storm, a large number of netizens flocked to the live broadcast room in Li Jiaqi to denounce it. Then, there were few questioning voices in the comment area, and the live broadcast room seemed to have returned to its former order. At 21: 42 on September 26th, the poster journalist entered the Taobao live room in Li Jiaqi, when he was carrying lipstick of Mao Geping brand, and the number of viewers in the live room was 7.146 million.

According to the International Finance News, the third season of the self-made variety "All Girls’ OFFER" produced by US ONE arrived as scheduled, showing the process of "negotiation" between Li Jiaqi and major beauty brands, which greatly promoted the upcoming "double 11". Janice (pseudonym), a well-known MCN organization engaged in beauty cosmetics vertical operation, said in an interview with the International Finance News that the Li Jiaqi incident had no impact on her MCN organization. "No matter what, the brand will still come to us for cooperation."

An insider of ONE told reporters that after the incident, the company’s publicity scale during the "double 11" period may be reduced, but "the traffic brought by the live broadcast room in Li Jiaqi is still very large." It is blunt that in the past few years, US ONE has established a large-scale system from product selection to after-sales improvement, and it still has advantages in the field of live e-commerce. "Especially after public relations, the trend of public opinion has become ‘ I don’t care about the anchor, anyway, as a consumer, it is good to buy a cheap and cost-effective product ’ 。” However, in the view of Wang Tian (pseudonym), a business practitioner of a live broadcast room in online celebrity, Tik Tok, if the live broadcast room in Li Jiaqi accounts for a large proportion of the brand’s performance planning of Taobao platform, after the storm, the brand may avoid risks by reducing the frequency of cooperation with Li Jiaqi and increasing the number of people to broadcast. "In the long run, the brand will expand other options besides super anchor. They also have their own plans and will not bet on one person. "

Upstream news is integrated from The Paper, Xinmin Evening News, International Finance News, Red Net, shanghai securities news, etc.

　　Screenshot of Tik Tok account of "Qinba Grandma Qinba Yiwei". The picture comes from the Internet.

　　In Shengli Community, Jincheng Street, Lin ‘an District, Hangzhou City, Zhejiang Province, young social workers guide the old people how to shop with their mobile phones. Xinhua News Agency reporter Xu Yushe

　　An elderly person is broadcasting live. The picture comes from the Internet.

　　In recent years, more and more middle-aged and elderly people shine brilliantly on the Internet platform. Sending short videos, opening live broadcasts and selling goods online … … They have subverted people’s traditional impression of old age, attracted a large number of fans to watch and become a beautiful landscape in the era of mobile internet.

　　"Silver-haired online celebrity" shows a different style

　　Accompanied by ancient music, four ladies dressed in batik cheongsam are walking leisurely. They are either holding red umbrellas or dancing folding fans, smiling and full of confidence. This is a 15-second short video released by Tik Tok’s account "Fashion Grandma Group", which has received nearly 1.5 million likes. It is hard to imagine that they are a group of "silver-haired online celebrity" with an average age of 68.

　　In Aauto Quicker, Tik Tok, bilibili and other short video platforms, countless "silver online celebrity" are everywhere. For example, Tik Tok’s account "Qinba Grandma Qinba Yiwei" records the rural life of two old people near Daba Mountain. Grandma’s cooking of braised pig’s trotters, potato Baba fried bacon, pulp water and other foods in southern Shaanxi made netizens salivate. At present, the account has gained 2.73 million fans and been praised more than 34 million times; The handsome "Grandpa Beihai" often wears a suit, a hat and a bow tie. His love for life and his spirit of "not being old" make many young people envy him. The short video released by "Grandpa Jigong" begins with "Dear Dolls", telling life experiences and talking about the world in simple language, as kind as grandpa next door; "Grandma Wang who only wears high heels" has a live broadcast with goods, and its sales can reach several million yuan, surpassing many young live broadcasts in online celebrity.

　　In the Internet era of "everyone has a microphone", the elderly are no longer network insulators. They pursue fashion, are confident and enthusiastic, know how to consume and love life, and show a unique style of "the most beautiful is the sunset red".

　　The 45th Statistical Report on Internet Development in China shows that by March 2020, the number of netizens in China reached 904 million, and the number of mobile phone users reached 897 million. Among netizens, netizens aged 50 and above account for 16.9%, and the number exceeds 150 million. The Internet continues to penetrate into middle-aged and elderly people.

　　Perceive the temperature of the years from the live broadcast

　　The reporter found out that the "silver-haired people" who are currently popular on the Internet are mainly divided into three categories: First, they show their young mentality and self-disciplined living habits. They often dress well and maintain a good posture and mental outlook, showing people the "exquisite life" of the elderly. The second is to record fragments of daily life. In the warmth and fun of the old people with their wives, children and grandchildren, netizens can feel the deep affection and see the true temperament of the old people who are childlike, lovely and straightforward. The third is to share life common sense and experience. Such as introducing health knowledge through live broadcast, recording short videos to interpret common scams and warning people how to deal with them.

　　What is the charm of "Silver-haired online celebrity"? Some insiders pointed out that there are three "degrees" advantages in online celebrity, namely, the length of life experience, the width of knowledge and the depth of professional fields. Specifically, the rich life experience and social experience of the elderly are not available to young people. They are well-informed, often thoroughly study their own professional fields, have strong comprehensive ability to deal with problems, and have a unique charm of time precipitation. When they express their little philosophies in life as experienced people, they will give people a sense of reliability and peace of mind.

　　Online celebrity’s old people have resonated with their peers, and at the same time, they have been loved and sought after by a large number of young people. For example, seeing the warm picture of "Grandma Qinba" and her wife taking care of each other, many netizens were envious and said that "this is love, and happiness is included in the plain". Industry analysts pointed out that, by contrast, the videos of Grandpa online celebrity and Grandma online celebrity are more authentic, frank and cordial, arousing many young people’s fond childhood memories, and arousing their yearning for their loved ones, family and affection, which is more penetrating and user-friendly.

　　The "silver hair economy" market is on the rise.

　　In May this year, "I’m Grandma Tian" in online celebrity, Tik Tok opened the first live show with goods, and achieved sales of 1.5 million yuan. Experts pointed out that behind the outbreak of "silver-haired online celebrity" is the rise of the trillion-dollar "silver-haired economy" market.

　　Recently, the China Development Report 2020: Trends and Policies of Population Aging in China issued by China Development Foundation said that by 2022, the population over 65 in China will account for 14% of the total population, realizing the transformation to an aging society. In 2050, the aging in China will reach its peak, and the population over 65 will account for 27.9% of the total population in China. "Silver-haired economy" will become a new growth point to promote the sustainable development of China’s economy in the future aging society.

　　Li Jia, deputy director of Pangu Think Tank Aging Society Research Center, believes that what middle-aged and elderly people need is to find more channels to release their abilities and energy and become participants in social development and progress. As the post-60s with higher education begin to retire, middle-aged and elderly people will be completely separated from the stereotype of "digital refugees" in the past, and their social needs are growing day by day, which is a good opportunity for the market to mature.

　　"Silver-haired online celebrity" not only spreads the positive energy of loving life and attaching importance to family, but also is a blue ocean with infinite opportunities. The insiders believe that the current market consumption potential of "Silver Hair online celebrity" has not been fully tapped, and there is still huge market space. To achieve the economic benefits of "silver-haired online celebrity", we need team packaging and continuous content output. In addition, due to limited energy, the old people are not familiar with the Internet economy and fans’ psychology, and the live broadcast of goods still faces no small challenge.

Cctv newsOn July 23rd, the State Council Joint Prevention and Control Mechanism held a press conference on the safety and effectiveness of vaccines in Covid-19. According to the report of the World Health Organization, the newly confirmed cases in the western Pacific where China is located increased by 37% last week, which is the fastest growing region in the world. Omicron’s BA.5 sub-branch has spread to more than 100 countries and regions around the world, resulting in an increase in the number of infections, hospitalizations and severe cases, and the pressure on China’s foreign countries to prevent imports is increasing.

Recently, the local epidemic situation has shown a trend of multi-point distribution and frequent occurrence. In some areas, the epidemic spillover has not been completely blocked, and the prevention and control situation is severe and complicated.

We must unswervingly adhere to the general strategy of "external defense input, internal defense rebound" and the general policy of "dynamic clearing". The areas where the epidemic occurred should deal with the clustered epidemic according to the local situation, concentrate resources and strength to quickly put it out, and quickly curb the spread of the local epidemic; Border areas and entry cities should strictly implement various measures for external defense input, strictly manage in a closed loop, and resolutely avoid the destruction of defense and the overflow of epidemic situation; Areas where no epidemic has occurred should continue to do a good job in normalization prevention and control, and maintain the efficient operation of the emergency response command system.

Covid-19 vaccination should be continued.

　　党的十八届六中全会通过的《关于新形势下党内政治生活的若干准则》（以下简称《准则》），站在政治和全局的高度，着眼全面从严治党，建设一个更加坚强有力的马克思主义政党，更好推进中国特色社会主义伟大事业，强调必须高度重视思想政治建设，把坚定理想信念作为开展党内政治生活的首要任务。这充分体现了以习近平同志为核心的党中央坚持思想建党、保持党的先进性和纯洁性的高度自觉，体现了我们党坚持不忘初心、继续前进的政治清醒。要认真学习贯彻《准则》精神，坚持以严格的党内政治生活锤炼坚定的理想信念，自觉成为共产主义远大理想和中国特色社会主义共同理想的坚定信仰者和忠实实践者，在全面建成小康社会、实现中华民族伟大复兴中国梦的历史进程中充分发挥先锋模范作用。

　　一、坚定理想信念是共产党人安身立命的根本

　　我们党从诞生之日起就把马克思主义写在自己的旗帜上，把实现共产主义确立为最高理想，鲜明表达了中国共产党人的政治理念、价值追求、行动纲领。坚定理想信念，就是要把对马克思主义的信仰、对社会主义和共产主义的信念作为毕生追求，矢志不渝为共产主义远大理想和中国特色社会主义共同理想而奋斗。

　　(1) Ideals and beliefs are the spiritual pillar of communist party people. People always have a little spirit. The spirit of communist party people is "revolutionary ideals are higher than the sky". It is with the support of this spirit that our party has withstood the bloody revolutionary test of bullets, life and death, the arduous pioneering test of hurricane and rain, the test of reform and opening up, and has continuously moved from victory to new victory and developed into the world’s largest ruling party. Just as Comrade Deng Xiaoping pointed out: "Why did we struggle out under very difficult circumstances in the past, and overcome numerous difficulties and dangers to win the revolution?"? It is because we have ideals, Marxist beliefs and communist beliefs. " Over the past 95 years, generations of communist party people have stood the test of blood and fire, life and death in their heroic struggle for national independence and people’s liberation, national prosperity and national rejuvenation. The key lies in their unswerving ideals and beliefs and their confidence in the bright future of a better society. "It doesn’t matter to behead, as long as the doctrine is true" and "The enemy can only chop off our heads and never shake our faith", all of which vividly show the steadfast and persistent spiritual pursuit of communist party people. Facts fully show that ideals and beliefs are the spiritual foundation and source of strength of communist party people. As long as you build a spiritual pillar with ideals and beliefs, you will not be afraid of any difficulties and challenges, and you will be able to overcome any difficulties and challenges.

　　（二）理想信念是共产党人的政治灵魂。理想信念是政治觉悟、思想境界、道德情操的集中体现。有了坚定的理想信念，就能坚持正确政治方向，在胜利时和顺境中不骄傲不自满，在困难时和逆境中不消沉不动摇，经受住各种赞誉和诱惑考验，经受住各种风险和挑战考验，永葆共产党人政治本色。习近平总书记反复强调，共产党人如果没有理想信念，或者理想信念不坚定，精神上就会“缺钙”，就会得“软骨病”，就必然导致政治上变质、经济上贪婪、道德上堕落、生活上腐化。当前，绝大多数党员干部理想信念是坚定的、政治上是可靠的，但也有一些人理想信念模糊甚至动摇。有的认为“理想很丰满，现实很骨感”，谈理想太远、谈信念太虚；有的不信马列信鬼神，热衷于算命看相、烧香拜佛；有的对中国道路和制度缺乏自信，总觉得西方的月亮比较圆；等等。这些现象和问题，应当引起高度注意。从一些领导干部违纪违法案件可以看出，他们之所以步入歧途、走上不归路，最根本的是思想政治出了问题，是理想信念出了问题。事实警示我们，理想信念动摇是最危险的动摇，理想信念滑坡是最危险的滑坡。只有坚定理想信念，Only in this way can we solve the "master switch" problem of world outlook, outlook on life and values, constantly strengthen our political determination and protect the political soul of communist party people.

　　(3) Ideals and beliefs are the ideological basis for maintaining the unity and unity of the Party. Ideals and beliefs are the spiritual banner of a political party’s unity and forge ahead, which determines the cohesion and centripetal force of a political party. Over the past 95 years, despite all kinds of setbacks and hardships, our party has always been United as one, unswerving and rock-solid, leading the people of all ethnic groups in the country to March forward bravely together, relying on the cohesion and inspiration of ideals and beliefs. At present, our party has more than 88 million party member and more than 4.4 million party organizations. Great changes have taken place in the party, and the situation and tasks it faces have changed greatly. How to unite and unite such a large party organization, form a common will, and maintain unity of action and keep pace? The most fundamental thing is to build up ideals and beliefs. The tortuous course of world socialist practice shows that once Marxist political parties give up their Marxist beliefs, socialist beliefs and communist beliefs, they will fall apart. The disintegration of the Soviet Union and the collapse of the CPSU are very important because the ideals and beliefs have been shaken, the ideological defense line has fallen, and the lessons have been extremely profound. Facts tell us that the decline of a political party often begins with the loss or absence of ideals and beliefs. Only by always holding high the banner of ideals and beliefs can we consolidate the ideological foundation of unity and ensure that the party is stronger and more prosperous.

　　Second, firm ideals and beliefs must be based on a profound grasp of Marxism.

　　Ideological and theoretical firmness is the premise of political firmness. Our party is a Marxist political party that is nurtured and nurtured with advanced ideas and armed with scientific theories. Party member and cadres, especially senior cadres, must take Marxist theory as a compulsory course, constantly improve their ideological awareness and theoretical level of Marxism, build a solid foundation of faith, supplement the calcium of spirit, and keep the rudder of thought steady.

　　(1) Unswervingly adhere to the guiding ideology of Marxism. Marxism is the fundamental guiding ideology for building the Party and the country, and it is also the core and soul of communist party people’s ideals and beliefs. When we say that we are firm in faith and loyal to the Party, we should first look at whether we unswervingly adhere to the guiding ideology of Marxism. If you deviate from or give up Marxism, you will lose your soul and lose your direction, and you will be alienated from the party, which is actually a betrayal of the party’s thoughts. On the fundamental issue of adhering to the unification of Marxist guiding ideology, we must be firm, and we must not engage in diversification of guiding ideology at any time and under any circumstances. To adhere to Marxism, the key is to make sure that our ancestors can’t lose sight of it, but also speak new words, so as to continuously develop Marxism in combination with the reality in China. Persistence is the foundation of development, and development is the best persistence. It is very harmful to treat Marxism with a skeptical and negative attitude, or with a pragmatic and dogmatic attitude. Over the past 95 years, the reason why our Party has been able to accomplish the arduous tasks that all kinds of political forces can’t accomplish in modern times, and to lead and promote China’s revolution, construction and reform to win great victories continuously lies in always taking Marxism as its own action guide, and persisting in constantly enriching and developing Marxism in practice. In the future journey, no matter what kind of setbacks and interference we encounter, we must firmly adhere to Marxism as the backbone.

　　（二）系统掌握马克思主义立场观点方法。马克思主义立场观点方法，是马克思主义科学思想体系的精髓所在。只有掌握了马克思主义立场观点方法，才能真正掌握马克思主义活的灵魂，从根本上提高马克思主义思想觉悟和理论水平，打牢理想信念坚定的基础。长期以来，我们党始终强调学习掌握马克思主义立场观点方法，并自觉用以研究和解决中国的实际问题。这不仅使马克思主义显示出巨大的真理力量，而且为马克思主义注入了强大的生机活力。我们学习马克思列宁主义、毛泽东思想、邓小平理论、“三个代表”重要思想、科学发展观，学习习近平总书记系列重要讲话精神，既要认真学习这个科学思想体系的基本内容，更要系统掌握贯穿其中的马克思主义立场观点方法，系统掌握马克思主义基本原理，学会用马克思主义立场观点方法观察问题、分析问题、解决问题，特别是要聚焦现实问题，不断增强改造客观世界和主观世界的能力。

　　（三）深入学习领会习近平总书记系列重要讲话精神。习近平总书记系列重要讲话，紧紧围绕坚持和发展中国特色社会主义，创造性回答了关系党和国家全局的一系列重大问题，进一步深化了对共产党执政规律、社会主义建设规律、人类社会发展规律的认识，是中国特色社会主义理论体系的最新成果，是当代中国马克思主义的最新发展，是指导我们进行具有许多新的历史特点的伟大斗争的鲜活的马克思主义。党的十八大以来，党和国家事业之所以能开新局、谱新篇，根本就在于以习近平同志为核心的党中央的坚强领导，根本就在于习近平总书记系列重要讲话精神的科学指导。我们学习马克思主义理论，筑牢理想信念之基，最重要的是把习近平总书记系列重要讲话精神学深悟透。要坚持读原著、学原文、悟原理，结合历史学、联系实际学，深入领会讲话的丰富内涵和核心要义，深入领会讲话贯穿的科学世界观和方法论，深入领会讲话蕴含的坚定信仰追求、历史担当精神、真挚为民情怀、务实思想作风和科学思想方法，做到真学真懂真信真用。

　　(4) Seriously study the party rules of party constitution. Party constitution is the general charter of governing the party, which embodies the basic theory and political proposition of the party, the collective will and the principle requirements of the party, and is the fundamental code of conduct that the whole party must abide by. Party rules are the extension and concretization of party constitution, and the concrete follow-up to regulate party member’s behavior. Ideals and beliefs are not abstract, but concrete, which is embodied in the specific provisions of party constitution’s party rules. To strengthen the cultivation of party spirit and strengthen ideals and beliefs, the most basic requirement is to learn the party rules and regulations of party constitution. At present, some cadres in party member have such problems as cheating, escaping and leaking. One of the important reasons is that they don’t learn party constitution’s party rules, forget party constitution’s party rules and don’t take party constitution’s party rules as a discipline. It can be said that whether we can seriously study and strictly abide by party constitution’s party rules is an important test of party member cadres’ party spirit and party loyalty, and also an important test of party member cadres’ ideals and beliefs. We should firmly establish party constitution’s awareness of party rules, regard party constitution’s party rules as the basic standard for strengthening party spirit cultivation and strengthening ideals and beliefs, consciously study party constitution’s party rules, strictly implement party constitution’s party rules, resolutely safeguard party constitution’s party rules, and truly internalize them in the heart and externalize them in the line.

　　Third, strive for the realization of ideals on the road of Socialism with Chinese characteristics.

　　To achieve lofty ideals and goals, we must have a firm and pragmatic trip. We should always maintain the spirit of struggle of the Communist Party of China (CPC) people when the Party was founded, hold lofty ideals, grasp realistic goals, unswervingly adhere to and develop Socialism with Chinese characteristics, and constantly push forward the great practice of fighting for lofty ideals.

　　(a) adhere to the practice of Socialism with Chinese characteristics’s common ideal and firm communist lofty ideal. Realizing communism is the highest ideal of communist party people. Communism can only be realized on the basis of fully developed and highly developed socialist society, which will be a very long historical process. Building Socialism with Chinese characteristics is an inevitable stage to realize communism, and Socialism with Chinese characteristics’s common ideal is the concrete embodiment of the highest ideal of communism at this stage. Therefore, Socialism with Chinese characteristics is the unity of the Party’s highest program and basic program, and the realization of the common ideal is essentially the same as the realization of the highest ideal. If you forget the highest ideal and only care about the present, you will lose your way and become utilitarian and pragmatic; Leaving the realistic goal and talking about the highest ideal will be divorced from reality and become utopianism. For communist party people, we can’t shout the slogan of communism every day and do things like "running into communism", and we can’t live without the beacon of communism. We should correctly understand the relationship between Socialism with Chinese characteristics’s common ideal and the lofty ideal of communism, base ourselves on the basic national condition that China is still in the primary stage of socialism and will be in it for a long time, and make unremitting efforts to realize the Party’s basic program at this stage.

　　（二）坚定中国特色社会主义道路自信、理论自信、制度自信、文化自信。理想因其远大而为理想，信念因其执着而为信念。习近平总书记强调，“当今世界，要说哪个政党、哪个国家、哪个民族能够自信的话，那中国共产党、中华人民共和国、中华民族是最有理由自信的。”为什么这样说？就是因为我们成功开创和发展了中国特色社会主义道路、理论和制度，继承和发展了灿烂辉煌的中华文化，使中国人民富起来了、中华民族强起来了，为人类对更好社会制度的探索贡献了中国智慧。当代中国的伟大社会变革，不是简单延续我国历史文化的母版，不是简单套用马克思主义经典作家设想的模版，不是其他国家社会主义实践的再版，也不是国外现代化发展的翻版，而是自己历经千辛万苦探索出来的正确道路，具有鲜明的独创性。坚定道路自信、理论自信、制度自信，说到底是要坚定文化自信。文化自信是更基础、更广泛、更深厚的自信。这种文化自信，来自于博大精深的中华优秀传统文化，来自于党领导人民创造的激昂向上的革命文化和生机勃勃的社会主义先进文化，来自于以爱国主义为核心的民族精神和以改革创新为核心的时代精神。我们要坚定中国特色社会主义必胜信念，Not afraid of any risks, not confused by any interference, we will create a more extraordinary "China miracle" and write a more wonderful "China story" on the journey of pursuing lofty ideals.

　　(3) Consciously work hard to advance the cause of Socialism with Chinese characteristics. Any great cause begins with ideals and ends with hard work. Without the spirit of hard work and hard work, no matter how great the goal is, no matter how beautiful the blueprint is, it can only be a castle in the air. Our Party has always emphasized hard work and hard work. From "arousing millions of workers and peasants to work with one heart" to "not doing anything, there is no Marxism at all", and then to "talking about making mistakes in the country and rejuvenating the country with hard work", the word "doing" has always been the loudest motto of the Communist Party of China (CPC) people. The red mountains and rivers of new China were shot down by countless revolutionary ancestors, one city and one pool; The magnificent building of socialism was built by countless laborers, brick by brick. Among them, thousands of outstanding party member cadres have devoted all their energy and even their lives. Without lofty ideals, he is not a qualified Communist party member; Leaving real work and talking about lofty ideals is not a qualified Communist party member. Today, it is even more necessary to work hard to promote the great cause of Socialism with Chinese characteristics, realize the goal of "two hundred years" and realize the Chinese dream of the great rejuvenation of the Chinese nation. We should aim high and be down-to-earth, embody the firmness of ideals and beliefs in the process of doing our job well, do every job well in a down-to-earth manner, and strive to achieve our excellent results in the "relay race".Leading cadres, especially senior cadres, should play an exemplary role and let party member and the masses feel the power of ideals and beliefs with practical actions.

　　四、持之以恒抓好理想信念教育

　　理想信念教育是党的思想建设的战略任务，是固本培元、补钙壮骨的基础工程，党的各级组织必须抓紧抓好。要采取更加有力的举措，把理想信念教育贯穿到全面从严治党全过程，融入到加强和规范党内政治生活各方面，不断提高全党思想政治水平。

　　（一）着力抓好党委（党组）中心组学习。党委（党组）中心组学习，是党的理论武装工作的重要抓手，是加强领导干部理论学习和理想信念教育的有效途径，对推动全党学习教育有着重要示范引领作用。要突出学习重点，加强马克思主义理论特别是习近平总书记系列重要讲话精神学习，加强党中央治国理政新理念新思想新战略学习，加强党章党规、党史国史学习。要创新学习形式，综合运用集体研讨、个人自学、专题调研等方式，提升学习质量和效果。要完善学习制度，加强督促检查，把学习情况作为领导班子和领导干部考核的重要内容，提高制度化规范化水平。要大力弘扬马克思主义优良学风，把理论学习同贯彻落实党中央重大决策部署结合起来，同解决改革发展稳定中的实际问题结合起来，真正做到学而信、学而用、学而行。广大党员干部特别是高级干部要自觉抓好学习，增强党性修养。

　　(two) efforts to guide party member cadres to distinguish between right and wrong, and resolutely resist the erosion of wrong ideas. At present, the mainstream in the field of ideological theory is good, with a loud theme and strong positive energy, but there are also some wrong thoughts and wrong views, some of which are still influential and confusing. If we don’t strengthen correct guidance and in-depth guidance, it will be difficult to unify the ideological understanding of party member cadres, and even shake our ideals and beliefs. It is necessary to improve the system of analyzing and reporting major ideological and theoretical issues within the Party, regularly judge and report important trends in the field of ideological and theoretical issues, objectively and comprehensively explain the deep-seated ideological and theoretical issues to party member cadres, and set the direction, say hello, draw the bottom line, defend the position and prevent erosion. We should focus on the erroneous ideological trends such as western constitutional democracy, "universal values", neo-liberalism and historical nihilism, and make a clear-cut analysis and criticism to guide party member cadres to recognize their essence and harm. The broad masses of party member cadres should stand firm in their political stance, stick to the political bottom line, dare to show their swords and confront each other in the face of erroneous ideological trends, and never let it go and stay out of it.

　　(3) Focus on improving innovative education methods. At present, great changes have taken place in the situation of the times and the ranks of party member, and the ways and means of ideal and belief education need to be improved and innovated accordingly. It is necessary to thoroughly study the characteristics and laws of ideal and belief education under the new situation, inherit good experience and practices, explore new ways and means, and constantly enhance the times and attractiveness. We should persist in carrying out centralized study and education within the Party, sum up and make good use of long-term practical experience, especially the fresh experience of the Party’s mass line education practice activities, "three strictness and three realities" special education and "two studies and one doing" study and education since the 18th CPC National Congress, so as to continuously educate and improve party member cadres. We should pay more attention to the ideological reality of cadres in party member, adhere to the combination of advanced requirements and extensive requirements, solve ideological problems with practical problems, and educate people with understanding and caring for people. It is necessary to make full use of all-media diversified forms of communication and use differentiated and interactive methods to enhance the pertinence and effectiveness of education.

　　(four) efforts to expand and expand the coverage of education. The education of ideals and beliefs should be carried out not only among cadres in party member, but also for the whole society. We should continue to deepen publicity and education in Socialism with Chinese characteristics, make clear the historical inevitability and great superiority of Socialism with Chinese characteristics, and maximize social consensus. It is necessary to carry out in-depth publicity and education on the Chinese dream, pay attention to spreading the Chinese dream with literary and artistic works, show the Chinese dream with patriotic education bases, cultivate the Chinese dream with mass theme activities, and guide the broad masses of the people to pursue their dreams together. It is necessary to further promote the construction of socialist core values, do a solid job of integration and implementation, and strive to promote compliance with the law and integration into social life, making it the common pursuit of all people. Ideal and belief education should pay special attention to young people, guide them to firmly listen to the party’s words and follow the party’s beliefs, and establish lofty life aspirations and lofty ideals.

　　■ In June, a total of 34.767 billion yuan of lottery tickets were sold nationwide, a decrease of 23.862 billion yuan or 40.7% over the same period of last year.

　　■ Not only did the monthly data decline, but the reporter combed the lottery sales data in the first half of the past decade and found that the lottery sales showed negative growth year-on-year for the first time in the first half of this year.

　　■ What causes the lottery market to be cold? What is the future trend of lottery market? The reporter combed and interviewed this.

　　Encounter cold

　　In the first half of the year, national lottery sales fell first.

　　Lottery sales were cold this year. From January to June, the national lottery sales totaled 212.596 billion yuan, a year-on-year decrease of 32.602 billion yuan or 13.3%. Among them, the sales of welfare lottery institutions was 97.757 billion yuan, a year-on-year decrease of 12.838 billion yuan or 11.6%; The sales of sports lottery institutions reached 114.839 billion yuan, a year-on-year decrease of 19.764 billion yuan or 14.7%.

　　The reporter combed 2010 — The lottery sales data in the first half of the decade in 2019 found that this was the first time that there was a year-on-year decline.

　　Judging from the monthly data, in June this year, the country sold a total of 34.767 billion yuan of lottery tickets, down 40.7% from the same period of last year. The year-on-year decline was mainly due to the large sales of quiz lottery games in the World Cup in June 2018, with a high base in the same period last year. In the first half of 2018, lottery sales increased by as much as 19.6%.

　　Looking back on the lottery market in the past ten years, from 2010 to 2012, it experienced a double-digit rapid growth period, and then the growth rate gradually decreased to single digits, and negative growth occurred for the first time in the first half of 2019.

　　The data shows that from 2010 to the first half of 2012, the national lottery sales maintained a rapid growth of more than 20%, which was a period of rapid growth of China’s lottery market; In 2013 and 2014, the growth rate of national lottery sales fell below 20%; From 2015 to the first half of 2017, the growth rate of national lottery sales dropped significantly, only 5.2%, 3.5% and 5.5% respectively.

　　Where do people prefer to buy lottery tickets when lottery sales are relatively low? Geographically, data from the Ministry of Finance show that in June, compared with the same period of last year, lottery sales in 31 provinces all declined. However, from the cumulative data in the first half of the year, compared with the same period of last year, lottery sales in five provinces increased, namely Sichuan, Shanghai, Henan, Anhui and Beijing, with year-on-year increases of 1.681 billion yuan, 234 million yuan, 190 million yuan, 172 million yuan and 45 million yuan respectively. As far as the overall sales volume in the first half of the year is concerned, Guangdong, Jiangsu, Shandong, Zhejiang and Henan rank among the top five in the country.

　　cause

　　Strengthen the supervision of high-frequency fast-opening games

　　Why did lottery sales decline in the first half of this year? An expert in the lottery industry told reporters that at the beginning of this year, in order to regulate the lottery market, the Ministry of Finance, the Ministry of Civil Affairs and other departments strengthened the supervision of high-frequency quick-opening games and quiz games, extended the sales time of high-frequency quick-opening games and reduced the number of lottery games.

　　High-frequency fast-opening games mainly complete the process from sales to lottery every few minutes or ten minutes through electronic equipment.

　　The data shows that in 2017, the share of Fucai quick-opening games in the total sales of Fucai reached 40%. In that year, the total sales volume of national welfare lottery was 216.977 billion yuan, of which the sales of quick-opening games was 87.522 billion yuan.

　　A lottery player told reporters: "The number of high-frequency fast-opening games is small, there are many awards, and the lottery is frequent. Many domestic lottery buyers are speculative when buying high-frequency fast-opening games, and some lottery buyers can play all day and easily lose their minds."

　　The reporter noted that in January this year, the Ministry of Finance, the Ministry of Civil Affairs, and the General Administration of Sports issued a notice to adjust the rules of high-frequency fast-opening lottery games and quiz lottery games, and strengthen the supervision of the lottery market. According to the notice, in recent years, China’s lottery industry has generally shown a sustained and healthy development trend. At the same time, there are still irrational lottery buying phenomena in the lottery market, such as unauthorized use of the Internet to sell lottery tickets and large bets. In particular, the market supervision of welfare lottery quick-opening games, sports lottery high-frequency games and sports lottery national online single-game quiz games needs to be strengthened. The notice is clear. From February 11th, if the sales time of high-frequency quick-start games is shorter than 20 minutes, it will be adjusted to 20 minutes.

　　Since 2019, the number of contests and events for the annual quiz game shall not be higher than 70% of the number of contests and events for sale in 2018. The aforementioned experts also pointed out to reporters that the main reason is that there was a World Cup in June 2018. At that time, the sales volume of lottery was particularly large, and the sales volume of sports lottery was also particularly large. However, there were no important sports events in June this year. The sharp decline in sports lottery sales in June was an important factor in the decline in lottery sales in the first half of the year.

　　Ban on sale

　　Internet lottery is banned.

　　The ban on internet lottery sales also has an impact on lottery sales. The reporter noted that in August 2018, the Ministry of Finance and other 12 departments jointly issued a document resolutely prohibiting the unauthorized use of the Internet to sell lottery tickets.

　　Internet lottery had previously shown a blowout growth trend in 2014. The huge sales volume of nearly 100 billion yuan makes internet lottery purchase an important force to promote the development of lottery market.

　　In 2014, Internet lottery experienced a glorious period. Major sports events, including the World Cup in Brazil, boosted the sales of Internet lottery by 102% from 42 billion yuan in 2013 to 85 billion yuan, accounting for 20% of the total lottery sales. According to the Analysis Report of Internet Lottery Market in 2014, there were more than 100 million users in China who bought lottery tickets through Internet channels, and the Internet became an important betting platform and channel for users.

　　Since then, since 2015, the Ministry of Finance and other departments have repeatedly issued a document to prohibit the sale of lottery tickets through Internet channels. However, during the 2018 World Cup, a large number of mobile apps illegally sold lottery tickets through the Internet.

　　At that time, there were many fish that escaped from the net without being investigated. According to media reports, some apps have stopped selling lottery tickets through the search of "lottery tickets" in Android and Apple mobile phone stores, but there are still many softwares that can buy lottery tickets. In the early days of the World Cup last year, many companies launched online lottery platforms again. Finally, many online football lottery platforms such as "Winning the lottery every day" and "Everyone Winning the lottery" stopped selling on June 20 last year.

　　reform

　　Standardize the management of welfare lottery issuance

　　The corruption case of Fucai Center exposed last year aroused social concern. On November 9, 2018, the website of the Central Commission for Discipline Inspection published a heavy article: "Pay equal attention to reduction and suppression, treat both the symptoms and the root causes, rebuild the credibility of Fucai, and the discipline inspection and supervision team stationed in the Ministry of Civil Affairs will promote the formation of a good political ecology from typical cases", with more than 4,000 words, and released confession videos of four former leaders of China Welfare Lottery Issuance Management Center.

　　Statistics show that since the 18th National Congress of the Communist Party of China, at least 14 people in the civil affairs system have been held accountable for issues related to welfare lottery. Fucai’s anti-corruption has a long time span and a wide range, and has become a case of systematic corruption. In addition to the four leading characters in the confession video published on the website of the Central Commission for Discipline Inspection, four members of the party group, including Li Liguo, former Minister of Civil Affairs, Dou Yupei, former head of the discipline inspection team in the Ministry, Qu Shuhui and Chen Chuanshu, former president of the China Aging Association, were held accountable.

　　After the corruption case of Welfare Lottery, the Ministry of Civil Affairs has improved the management system of welfare lottery issuance, sales, distribution and use of public welfare funds, such as changes in the internal institutions in charge of welfare lottery management.

　　According to the Regulations of the Ministry of Civil Affairs on Functional Allocation, Internal Organizations and Staffing, before the reform, the management of welfare lottery was in charge of the Department of Social Welfare and Charity Promotion; After the reform, the welfare lottery management has been refined, and the planning and finance department and the newly established charity promotion and social work department are in charge.

　　On July 29, the Ministry of Civil Affairs held a press conference, and the relevant person in charge introduced that there are three main reform directions in regulating the issuance and management of welfare lottery tickets. First, cooperate with the Ministry of Finance, comprehensively rectify the unauthorized use of the Internet to sell welfare lottery tickets, and comprehensively carry out self-examination and inspection of national welfare lottery institutions and consignment agents. Second, vigorously adjust the rules of the quick opening game of welfare lottery to resolve the market risks of welfare lottery. The third is to improve the welfare lottery issuance management system.

On August 9, 2023, Hangzhou Asian Games Organizing Committee released the sample design of paper tickets and electronic commemorative tickets for sports competitions.

The face design of paper tickets for Hangzhou Asian Games revolves around urban cultural connotation, interactive sharing among the whole people, sublimation of Asian Games theme, etc., based on the core graphic "Moist", with laurel yellow as the main color in the core color system "Light Makeup and Heavy Makeup", combined with the silhouette design of Hangzhou landmark attractions such as "Three Tans Printing the Moon" and various competition sports icons, through the cultural collision between history and modern times, it conveys the unique cultural charm of the host city and forms a unified vision with the image of Hangzhou Asian Games.

In order to appeal to the whole people to help the Green Asian Games, Hangzhou Asian Games recommended the use of electronic tickets. Users who purchase electronic tickets can sell tickets on the official website H5 page and the Smart Asian Games One-stop • The electronic commemorative tickets of the corresponding project are extracted from the ticket folder of the ticket service, and the exclusive ticket book is generated, which is convenient for collection, sharing and dissemination. Electronic commemorative tickets can be divided into four types: gold, silver, copper and general, and the winning proportions are 5%, 10%, 15% and 70% respectively. Electronic commemorative tickets and exclusive electronic ticket books are first used in comprehensive sports games held in China, which is a vivid embodiment of the concept of intelligent competition.

A variety of anti-counterfeiting technologies are adopted for the tickets of sports competitions in this Asian Games, which are easy to identify and difficult to copy. At the same time, the intelligent application of technologies such as Internet, big data and blockchain in ticket inspection and ticket anti-counterfeiting is used to provide the public with a new experience of intelligent ticketing. The ticketing blockchain is used to record every node of tickets from production to use. Ticket holders can trace the information through the two-dimensional code of tickets. Paper tickets can be viewed directly by scanning the code, and electronic tickets can be viewed by clicking on the ticket folder details page.

(Headquarters reporter Xia Zhou Jinjian Jiang Wei Liu Yi)

Q:What are the nutrition and health problems of Shanghai residents?

A:It is not eating too much, but the dietary structure is unreasonable, mainly because there are less plant foods (cereals/vegetables/fruits) and more animal foods (livestock and poultry meat); The proportion of fat in diet is high, and the energy provided by fat is 38.0%, which exceeds the recommended upper limit of 30%.

First, the problem of overweight and obesity is prominent. As far as diet is concerned, the problem is unreasonable dietary structure (more animal food/less plant food, high fat ratio).

The overweight and obesity rate of Shanghai residents is 44.1%, which is close to the average level of cities in the national nutrition monitoring results from 2010 to 2013 (the overweight and obesity rate of big cities in China is 47.8%). Shanghai residents don’t eat too much. The energy intake of Shanghai residents is lower than that of 10 years ago, which may be related to the change of lifestyle, people no longer engaged in manual labor, and the decrease of energy demand, as well as the trend of energy intake of people found in international and our country’s nutrition monitoring.

There are many factors that cause obesity. As far as dietary factors are concerned, the main problem of Shanghai residents is the unreasonable dietary structure. The traditional Chinese diet mainly takes plant food (cereal is the staple food), which is rich in dietary fiber, which is beneficial to prevent chronic diseases. However, current monitoring shows that the intake of animal food in residents’ diet greatly exceeds the recommended level, while the intake of cereal has dropped significantly in the past 10 years, and the intake of vegetables and fruits is insufficient. Such a dietary structure contains less dietary fiber, which is not conducive to the prevention of chronic diseases. At the same time, the absorption rate of different foods in the human body is different. The current dietary structure may increase the absorption rate of food, which may lead to the increase in the overweight and obesity rate of residents.

On the other hand, the monitoring also found that the percentage of energy provided by residents’ fat was 38.0%, which was close to the average level of big cities (37.2%) in the national nutrition monitoring results from 2010 to 2013. In the recommendation of Dietary Guidelines for China Residents, the percentage of energy provided by dietary fat does not exceed 30%, which has now exceeded the upper limit by a lot. Animal foods, especially livestock and poultry meat, contain more saturated fat. The monitoring results show that the intake of livestock and poultry meat in Shanghai residents’ animal foods exceeds the recommended 61%.

Second, suggestions on unreasonable dietary structure: increase plant food, reduce animal food, and replace some livestock and poultry meat with aquatic products.

1. Increase the intake of plant foods such as cereals, vegetables and fruits.

In view of the dietary nutrition problems found by monitoring, it is suggested that residents gradually improve their dietary structure and increase the intake of plant foods such as coarse grains, vegetables and fruits. Usually, people’s food intake in a day is relatively stable. If the intake of plant food increases, the intake of animal food will decrease accordingly.

It is worth noting that in the past 10 years, the grain intake has dropped significantly. At present, the grain intake of residents is 189.6g, which only reaches 69% of the recommended intake (the recommended intake is 200-300g, compared with 275g/2200kcal). It is suggested that residents should increase the intake of cereals, and at the same time, they should match the thickness, and pay attention to increasing whole grains and miscellaneous beans, because cereals with high processing precision will cause high blood sugar response. Rice can be eaten with whole grains (brown rice), miscellaneous grains (oats, millet, buckwheat, corn, etc.) and miscellaneous beans (red beans, mung beans, kidney beans, flower beans, etc.).

2. Reduce animal food, you can choose aquatic products to replace some livestock and poultry meat.

At the same time, it advocates food diversification. In view of the problem of excessive intake of livestock and poultry meat by Shanghai residents, it is recommended that residents can choose aquatic products to replace some livestock and poultry meat. Livestock and poultry meat contains saturated fat, which is a risk factor for cardiovascular diseases and tumors. Aquatic products contain unsaturated fat, which is beneficial to health.

Finally, it is recommended to choose at least 12 different foods every day to prevent the risk of chronic diseases caused by possible nutritional deficiency or excess.

Third, the rising trend of overweight and obesity among students has not been curbed, and sugary drinks are widely consumed. Excessive drinking of sugary drinks is one of the risk factors of overweight and obesity, so it is suggested that students should be controlled to drink sugary drinks.

There are many factors that cause overweight and obesity, except the unreasonable dietary structure mentioned just now. In addition, there are differences between primary and secondary school students and adults. This monitoring found that it is common for primary and secondary school students to drink sugary drinks. 74.6% primary and middle school students drink sugary drinks more than once a week, and 36.5% primary and middle school students often drink them. It is more common for high school students to drink sugary drinks, and 62.5% of them often drink them. There are also a few students who drink sugary drinks every day. 20.9% of primary and secondary school students drink sugary drinks more than once a day, and the proportion of high school students is even higher. There are 41.5% of high school students who drink sugary drinks more than once a day.

The Dietary Guidelines for China Residents (2016 Edition) recommends that children and adolescents prefer boiled water to sugary drinks every day. Drinking sugary drinks does not produce satiety, resulting in excessive intake of sugar and energy. According to literature reports, excessive intake of sugary drinks can easily lead to various diseases such as obesity, diabetes, metabolic syndrome and blood lipid problems.

It is suggested that primary and secondary school students should be restricted from drinking sugary drinks, students should be encouraged not to drink sugary drinks, and extra sugar and energy intake should be reduced. Parents and school teachers should be aware of the influence of sugary drinks on children’s overweight and obesity. It is suggested that schools should encourage students not to bring sugary drinks into school, schools should not provide sugary drinks for sale, and widely carry out health knowledge propaganda on restricting sugary drinks in schools.

4. The intake of oil and salt in Shanghai has obviously decreased in recent 10 years, thanks to the measures to control oil and salt in Shanghai, but the current intake of oil and salt is still higher than the recommended level, and it is necessary to continue to strengthen intervention.

Our diet is mainly salty, and frying, frying and frying are common cooking methods. Excessive intake of cooking oil and salt in the diet is one of the important factors causing hyperlipidemia and hypertension. According to the monitoring results, the daily per capita intake of cooking oil and salt is 36.4g and 7.5g, respectively, which are 21% and 24% lower than the survey data 10 years ago, and 11% and 16% lower than the national average of big cities.

We compared the trend of oil and salt intake in Shanghai in recent 10 years, and found that it was obviously decreasing. At the same time, we also looked at the trend of oil and salt intake in urban areas of China in recent 10 years, but there was no obvious downward or upward trend, and it remained basically stable. This difference in trend should be attributed to the health education and intervention on oil and salt control led by the Shanghai Municipal Government in the past 10 years, such as the distribution of "salt control spoons" and "oil control pots" throughout the city in 2008 and 2009, so that the vast number of Shanghai residents can truly experience the quantitative concept of "eating less salt and putting less oil" and turn the traditional propaganda slogan into a reality for residents.

Residents’ intake of cooking oil and salt decreased obviously, thanks to various health education and intervention led by the Shanghai municipal government in the past 10 years, which is a good aspect. On the other hand, we should also see that the intake of oil and salt for eating at home is still higher than the recommended standard. The recommended daily intake of oil and salt is no more than 25 grams per day, and the current intake of cooking oil and salt for residents is still far from the recommended level. Measures to control oil and salt should continue to be strengthened.

5. At present, it is common for residents to eat out (61% residents eat out). In addition to traditional intervention in family cooking, institutions such as restaurants and canteens should be intervened in the future.

From the monitoring data, we also found that the current rate of residents eating out is 61%, which is much higher than the national rate of urban residents eating out of 42%. The people who eat out in Shanghai are mainly young people aged 15-44. People used to eat at home, but now they eat out more and more. We can also see from ourselves that prepackaged foods (that is, packaged food, such as cakes, bread, sausages, etc.) has become a new choice. The development of science and technology has made life more convenient, and the rise of new consumption methods such as take-away and online shopping has affected the traditional family cooking habits. These changes pose new challenges to traditional nutrition intervention strategies.

The monitoring also found that the sodium intake of Shanghai residents was 4927.2mg, which was nearly 1.5 times higher than the recommended level. Excessive intake of sodium is closely related to the increase of blood pressure and the occurrence of hypertension. At present, the sodium intake of residents through salt accounts for 3/5 of the total sodium intake. Besides salt, sodium comes from salty condiments (such as soy sauce, monosodium glutamate, etc.), semi-finished dishes, pickled products, snacks, etc. (common sweet preserves also contain a lot of sodium), and vegetables also contain a certain amount of sodium. In the past, we actively advocated reducing salt intake, which can reduce sodium intake. As mentioned just now, residents’ eating style has changed. More and more people eat out, and they choose more packaged foods. In order to control the intake of sodium, besides controlling the intake of salt, they also reasonably choose condiments, packaged foods and snacks containing sodium.

In the past, our intervention measures to control oil and salt covering the whole city have made great achievements, but the intake of oil and salt for residents to eat at home is still higher than the recommended level. For future intervention and publicity, we will continue to strengthen the implementation of intervention measures to control oil and salt. On the other hand, we will also keep pace with the times, not only to continue to publicize the knowledge of reasonable nutrition for residents, but also with the popularity of residents eating out. Centralized dining halls, restaurants, take-away service providers, and prepackaged foods enterprises will also be the key targets for nutrition promotion in the future, advocating the supply of catering and food with "reducing salt, limiting oil and reducing blood sugar", encouraging dining places to carry out nutrition propaganda, formulating easy-to-understand nutrition labels in prepackaged foods, and guiding residents to choose food reasonably.

In addition, it is recommended that everyone eat at home, adhere to the habit of cooking at home with less oil and salt, and at the same time, eating at home also promotes the emotional exchange and promotion of family members.

6. Insufficient calcium intake is common, and residents drink less milk every day. It is suggested that residents increase the frequency of drinking milk and increase the intake of soybeans and bean products.

Our traditional Chinese diet is mainly based on plant food, which is conducive to the prevention of chronic diseases, but it also has an obvious defect, lacking a good source of calcium. Milk is a good source of calcium, and Chinese diet does not contain milk. A good phenomenon found in this monitoring is that residents have the habit of drinking milk, 41.6% residents consume milk every day, and 71.4% students consume milk every day. However, 86.8% residents still have insufficient calcium intake. Milk supplements the calcium that is insufficient in daily diet. Calcium is an integral part of bones and teeth, and it is an important nutrient for physical growth and bone development. Calcium deficiency will affect normal growth and development and cause osteoporosis. The Dietary Guidelines for China Residents (2016 Edition) recommends that each person should take 800mg of calcium daily, and students in the growth stage need 1000-1200mg. Every 100ml of milk contains about 104mg of calcium. In addition to the calcium in daily diet, 300ml of milk is needed every day. At present, the monitoring results show that the daily milk intake is insufficient. The average daily milk intake of residents is 97ml, and that of primary and secondary school students is 150ml.

Encourage residents to increase the amount of milk they drink. If the single intake is small, they can increase the number of times they drink milk, improve the calcium intake level and ensure the normal demand of the body. People who are lactose intolerant can choose low lactose milk or yogurt. At the same time, soybeans or bean products are also a good source of calcium. The Dietary Guide for Residents in China recommends that they consume 25g soybeans or a considerable amount of bean products every day. At present, residents’ intake of soybeans and bean products is less than half of the recommended amount. It is suggested that residents increase their intake of soybeans or bean products.

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