Last night, Andy Lau held his second concert in Singapore, and there was still a lot of singing and dancing at the scene. But what was even more noticeable was that at halftime, all the fans began to sing the birthday song. It turned out that today was Andy Lau’s 58th birthday, so the fans had been preparing for a big surprise for Andy Lau.

Andy was also touched by the fans that day, and Andy kept blowing kisses to the fans, and the whole scene was real spectacular. Presumably only Andy can have such treatment, so Andy also sang with the fans at the scene. The scene was really warm and harmonious, so Andy kept blowing kisses to the fans.

Andy Lau’s first concert in Singapore was also quite exciting, and Andy Lau was also moved to tears by the fans at the scene, and began to sob directly at the scene, which made the fans really feel distressed and comforted Andy to be strong, because you have always been accompanied by us.

This time Andy Lau’s "my love" world tour concert can be said to be quite successful. For example, the recent concert in Malaysia was also proposed by female fans on the spot. It can be said that this time Andy Lau really has surprises everywhere. So "my love" is the love that Andy Lau gives to fans, and it is also the love that fans give to Andy Lau.

On Andy Lau’s 58th birthday, the whole concert in Singapore sang the birthday song, and Andy blew kisses. At the same time, Andy Lau also sang classic songs such as "Chinese" at the concert, which made the Chinese fans on the scene excited again. I have to say that Andy is really a well-deserved idol. We also hope that Andy’s concert will be a complete success. Happy birthday.

JAC iC5
New car features: NEDC battery life up to 530km
IPO time: May 10

　　The Jianghuai iC5 is based on Jianghuai’s new 432 platform, and its appearance and shape are similar to the Jiayue A5 on the same platform. Its appearance is very simple and handsome, and the polyline design can be seen everywhere. In terms of size, the length, width and height of the new car are 4770/1820/1514mm respectively, and the wheelbase is 2760mm. The rear of the vehicle is clearly layered, and the opening shape on both sides of the rear insurance echoes the design of the front of the car.

　　The interior of the Jianghuai iC5 uses a black rice color scheme + chrome plating + piano paint trim to bring a good texture. The large central control screen and simple design style enhance the sense of technology in the car a lot. In terms of configuration, the car has 64-color ambient lights, as well as a powerful vehicle to everything car system. Built-in iFLYTEK intelligent voice control, can recognize a variety of dialects, and controls multimedia, navigation, telephone, air conditioning, sunroof, etc., through voice control, and also has car Wi-Fi.

　　In terms of active and passive safety configuration, the JAC iC5 high-end model features intelligent ramp assistance, body stabilization system, ABS + EBD, emergency braking assistance, adaptive cruise, lane keeping assistance, lane departure warning, traffic sign recognition, and more.

　　The new car retains the hatchback tailgate design of the Jianghuai Jiayue A5, which is rare in models of the same class. In addition, the rear air conditioner is out of trend and the rear seats are divided into 4/6 proportions. In terms of power, the Jianghuai iC5 has a maximum power of 204 horsepower and a peak torque of 340 Nm. The acceleration time of 0-100km/h is 7.6 seconds. With a 64.5kWh lithium battery, the NEDC battery life can reach 530km.

Editor’s comment:

　　The appearance of the Jianghuai iC5 is very simple and spiritual, giving people a good first impression, and I believe it will win the favor of young people. Since it is a pure electric car, the cruising range is naturally the focus of everyone’s attention. The official data of the Jianghuai iC5 is 530km (NEDC battery life), which is also good. As for the configuration, it is comparable to the Chinese brand models of the same class, and it is difficult to distinguish between the top and the bottom.

　　In the case of a relatively balanced book strength, the deciding elements also include the texture of driving and interior materials, which can only be evaluated when we get the Jianghuai iC5 test car. For Jianghuai, it is also necessary to set an attractive and competitive price for the iC5 to make up for the weakness of brand recognition.

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Zero run T03
New car features: miniature car/battery life up to 403km
IPO time: May 11

　　As early as April 10, the Zero Run T03 had been on pre-sale. The new car was positioned as a miniature pure electric vehicle, and the appearance adopted what the official called the "curved design aesthetic" style, which looked quite cute. In terms of body size, the length, width and height of the T03 were 3620/1652/1577mm respectively, and the wheelbase was 2400mm.

　　The interior design of the new car is simple, and the central control screen integrates most functions. The Zero Run T03 is quite high, such as facial recognition start system, Leap On smart car system, etc.; and the T03 has the hardware foundation of "3 cameras + 1 millimeter wave radar + 11 ultrasonic radar" and up to 10 autonomous driving auxiliary features, including: APS intelligent parking system, ACC adaptive cruise system, LDW lane departure warning system, LKA lane keeping assistance system, FCW front collision warning system, AEB automatic emergency braking system, etc.

　　In terms of power, the Zero Run T03 is equipped with the Heracles electric drive assembly independently developed by Zero Run, with a maximum power of 55kW (75Ps) and a maximum torque of 155Nm. The battery pack adopts the ternary lithium battery of Ningde era, and the energy density of the battery system is as high as 171Wh/kg. According to the previous declaration information, the battery capacity of the new car is 31kWh and 38kWh, and the corresponding NEDC cruising range is 300km and 403km respectively.

Editor’s comment:

　　The Zero Run T03 is positioned as a mini car. From the perspective of body length (3620mm), it is longer than the Euler R1 (3495mm) and BYD e1 (3465mm). In addition, the slightly square body helps to improve the head space of the second row. So the Zero Run T03 gives people the feeling of a more practical mini car.

　　At present, the Zero Running T03 has started pre-sale, and the pre-sale price after subsidy is less than 80,000 yuan. Surprisingly, its configuration is very awesome, and this level of models equipped with L2-level intelligent driving assistance is indeed rare. At the same time, the new car is also equipped with the Leap On smart car system. Most importantly, its range is enough to complete the task of daily city commuting.

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SAIC MAXUS EUNIQ 5 PLUG IN
New car features: plug-in hybrid model
IPO time: May 18

　　As a plug-in hybrid model, SAIC MAXUS EUNIQ 5 PLUG IN continues the overall shape of the EUNIQ 5, both of which also adopt a new energy design style. The closed air intake grille is embellished with blue elements, and a larger front lip is added under the front surround. The shovel-like shape highlights the movement and looks very fashionable.

　　From the side, the standard MPV style design adds a sense of style to the new car due to the use of a suspended roof. In terms of size, the length, width and height of the new car are 4825/1825/1778mm, and the wheelbase is 2800mm.

"The picture shows SAIC MAXUS EUNIQ 5"

　　In terms of the interior, the new car should still use the pure electric version of the interior layout, equipped with a 7-inch LCD instrument panel and a 12.3-inch floating touch screen, and equipped with "Zebra Zhixing System". The new car offers wireless charging, head-up display, automatic emergency braking, lane keeping assistance, panoramic imaging, panoramic sunroof and seat heating.

"The picture shows SAIC MAXUS EUNIQ 5"

　　Power is the biggest highlight of the new car. The motor of the new 1.3T engine forms a plug-in gasoline-electric hybrid power system, with a maximum engine power of 163 horsepower and a maximum motor power of 82 horsepower. The comprehensive pure electric cruising range is 64km.

Editor’s comment:

　　SAIC MAXUS EUNIQ 5 PLUG IN is a plug-in hybrid model. For many friends, it is undoubtedly a more secure choice at present, without mileage anxiety, and at the same time can be supported by relevant policies. Since it is built on the same platform as the EUNIQ 5 pure electric version, their appearance, interior and even configuration will not be significantly different. Recently, SAIC MAXUS EUNIQ 5 PLUG IN has opened pre-sale, and the new car will launch 5 models. The only suspense is the price.

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SAIC MAXUS EUNIQ 6
New car features: two power versions/power balance
IPO time: May 18

　　The SAIC MAXUS EUNIQ 6 is based on the SAIC MAXUS MERA intelligent scalable mid-size vehicle platform, which is compatible with pure electric, hybrid, and fuel powertrain layouts.

　　Among them, the EUNIQ 6 PLUG IN (hereinafter referred to as the plug-in hybrid version) adopts a new air intake grille design. The appearance of blue decorative strips emphasizes the new energy identity of the new car. At the same time, blue decoration is also added to the headlight group to highlight. In addition, the new car shape is basically the same as the fuel car, and even equipped with the same 19-inch wheels.

　　The EUNIQ 6 is a pure electric model with a more futuristic feel. The new car has cancelled the plug-in hybrid version of the air intake grille shape, and the design of the full LED headlight group has been continued, resulting in a very fashionable visual effect. In addition, the new car will also be equipped with a separately designed low wind resistance rim, and the two exhaust layouts at the tail side have been cancelled, and the chrome decoration design has been changed. In terms of size, the two models remain the same, with a length, width and height of 4735/1860/1736mm respectively, and a wheelbase of 2760mm.

　　In terms of interior layout, the two use the same design. The leather-wrapped interior with stitching process and Alcantara fabric seats enhance the texture of the vehicle, and the 12.3-inch full LCD meter, head-up display and 14-inch center console display are equipped to further enhance the technological atmosphere of the vehicle. The 14-inch central control display adopts touch design and is embedded with Zebra Zhixing Internet System 3.0, which can control air conditioning, music, navigation, sunroof opening/closing, express inquiry, weather inquiry and other functions through voice.

　　In addition, the air-conditioning control area of the new car is also integrated into the central control screen, making the center console appear very simple. However, the new car does not cancel all physical buttons, and there are necessary driving auxiliary features around the shift lever.

　　It is reported that SAIC MAXUS EUNIQ 6 will also support SAIC MAXUS’s C2B intelligent customization mode. In terms of configuration, it also provides panoramic sunroof, 64-color ambient light, electric tailgate, mobile phone wireless charger, etc. In terms of safety configuration, it provides panoramic surround view system (360-degree panoramic image + transparent chassis system), parking sentry mode, tire pressure monitoring, DRS driver identification system, and supports Face ID to start the vehicle, driver fatigue reminder, in-car environment remote monitoring, etc.

　　In terms of power, the EUNIQ 6 PLUG IN is equipped with a plug-in gasoline-electric hybrid system composed of a motor of SAIC GM’s 1.3T engine. The maximum power of the engine is 163 horsepower, the maximum power of the motor is 82 horsepower, and the comprehensive pure electric cruising range is 62km.

　　The EUNIQ 6 will be equipped with a motor with a maximum power of 177 horsepower and a peak torque of 310 Nm. The power battery is a ternary lithium battery provided by Ningde Times, with a battery capacity of 70kW · h. It has the latest generation of battery heating management system and battery management system, supports fast charging mode, and has a range of 510km under NEDC comprehensive operating conditions.

Editorial comments:

　　SAIC MAXUS EUNIQ 6 can be seen as a main force for SAIC MAXUS to enter the new energy market, as a medium-sized SUV. Thanks to the generalization of the MERA platform, the new car has adopted a more mature design style. Judging from the upcoming version, the pure electric version and the plug-in hybrid version have a double insurance feeling. For SAIC MAXUS, in addition to the strength of the product itself, it is necessary to quickly improve the brand’s recognition among consumers, which takes time to accumulate.

"The number of 48-hour bookings exceeded 20,000."

　

On November 19th, Extreme Krypton Motor released the above data, once again refreshing the pure electric market record with "extreme Krypton speed".

　

At the Guangzhou International Auto Show in 2023, the first pure electric luxury car, Krypton 007, made its debut, and the pre-sale started at the same time. The pre-sale price started from 229,900 yuan. Before the launch, the user paid 1000 yuan the intention money to deduct 6,000 yuan, and the pre-sale price started from 224,900 yuan.

　

The whole system comes standard with 800V platform, front double wishbone and rear multi-link suspension, silicon carbide motor and Qualcomm 8295 chip. The total power of front and rear motors is up to 310 kW, and the four-wheel drive model accelerates for 2.84 seconds. ……

　

A series of luxury configurations beyond the same level, Extreme Krypton 007 entered the pure electric luxury car market by breaking the conventional brand-new luxury standards, providing users with more and more novel category choices.

　

Establish a new standard for pure electric cars against Tesla Model 3 and Krypton 007.

　

As the fourth model of Krypton, it is also the first car product to enter the most mainstream market. Based on the insight into the market and users, the appearance of Krypton 007 has chosen a more "advanced" design concept, breaking the status quo of "one thousand cars".

　

By Stefan Sielaff, the former design director of Bentley who joined Krypton two years ago, Krypton 007 reached the best visual point of a luxury B-class car: the length of the car is 4865mm, the width of the car is 1900mm, the height of the car is 1450mm, and the wheelbase is 2928mm, achieving a perfect 1:2 ratio of the height of the yellow gold wheels.

Caption: Extreme Krypton 007. Figure/Enterprise official website

The world’s first double-zone hidden front face design makes the Krypton 007 have a smoother and more recognizable front face. The exclusive clamshell front hatch cover and clamshell tailgate design of ultra-luxury SUV were first introduced into the B-class sedan by Krypton 007, creating the first real suspended roof in its class.

　

Extreme Krypton 007 headlight group uses the world’s largest 90-inch giant screen light strip and 1711 LED light beads, and the brightness can reach 10000 nits, bringing a visual interaction effect with a sense of future technology. The most surprising thing is that the light curtain is independently controlled by 75 high-power chips of vehicle specifications, and the pattern can be presented on the smart light curtain just by drawing on the central control panel with your fingers, which makes Kyk 007 the first smart electric vehicle in the world that can be customized by users, and also allows users to have personalized exclusive labels.

Caption: Extreme Krypton 007 interior. Figure/Enterprise official website

Not only comes with a brand-new image, but also with the powerful performance genes, safety genes, intelligent technology and luxury configuration of the brand, Krypton 007 breaks the rules and establishes a new standard for pure electric cars.

　

In terms of power, Extreme Krypton 007 not only inherits the luxury performance gene of Extreme Krypton 001 FR, but also comes standard with high-performance 800V architecture. The whole system comes standard with front double wishbone and rear multi-link high-performance suspension system, equipped with 800V silicon carbide high-performance rear motor with a maximum power of 310 kW. The fastest acceleration of the rear-wheel drive model is 5.4 seconds, and that of the four-wheel drive model is a record-breaking, with the fastest acceleration of 2.84 seconds (excluding the starting time), which is faster than the 3.4 seconds (excluding the starting time) of the Tesla Model 3 high-performance all-wheel drive version. It has become the fastest accelerating pure electric car of its kind in the world.

　

In terms of cruising range, the cruising range of CLTC, the entry-level model of Krypton 007, is 688 kilometers, and the long-life version is as high as 870 kilometers.

　

With 800-volt high-voltage architecture, 800-kilometer battery life and 800-seat exclusive charging stations, with the absolute strength of three "800", Extreme Krypton 007 will completely eliminate users’ travel mileage and recharge anxiety.

Caption: Comparison between Extreme Krypton 007 and Tesla models.

In the luxury pure electric car market, Tesla Model 3 is an unavoidable opponent of cars of the same price. However, with the consumer’s demand for interior space and comfort, the sales volume of Model 3, which has not been greatly upgraded for 8 years, has declined in recent years, and the sales volume in the third quarter of this year is only one-third of that of two years ago. Based on the insight into the market and users, Extreme Krypton 007 is fully configured, and it is more competitive than Tesla Model 3 in key parameters such as body size, wheelbase and battery life.

　

Create a differentiated competitive advantage and be a "leader" in market segments.

　

Extreme krypton 007 is a concentrated expression of extreme krypton’s soft and hard strength. As a luxury intelligent pure electric brand under Geely Holding Group, Krypton is also continuing to create "Krypton speed".

　

Different from other enterprises, Krypton firmly takes the "third track", that is, "combining the power of giants with pure user thinking."

　

In less than three years since its establishment, Extreme Krypton has successively launched the hunting coupe extreme Krypton 001, MPV extreme Krypton 009, compact SUV extreme Krypton X and super-running extreme Krypton 001 FR, covering the price range of 200,000-800,000 yuan.

　

In 2022, the annual delivery of Krypton exceeded 70,000 vehicles, making it the only brand of mainstream new energy to achieve the delivery target. By the end of October 2023, the monthly delivery of krypton has increased for nine consecutive months. It took only 24 months to start delivery, and Krypton became a luxury pure electric brand with the fastest delivery of 170,000 vehicles, with a cumulative delivery of more than 170,000 vehicles, the only one in the industry with zero spontaneous combustion, which set a new record in the industry.

　

Among them, Kykrypton 001 is the champion of pure electric vehicle sales with a price of over 300,000 yuan, Kykrypton 009 is the champion of MPV sales with a price of over 500,000 yuan, and Kykrypton X is the only China brand in the top ten of compact car sales with a price of over 200,000 yuan.

　

In terms of globalization strategy, in October this year, Krypton signed a pan-European cooperation agreement with BNP Paribas and Arval, which will provide users with financial solutions covering all aspects of travel, all-round leasing business support and insurance services, covering many European countries.

　

In November, Krypton started selling in Stockholm, Sweden, and will be sold in major developed countries in Western Europe next year. In 2024, the European market is expected to increase to 6 countries, and in 2025, it will enter 8 countries, accelerating its March to the global market.

Caption: An Conghui, CEO of Extreme Krypton Intelligent Technology. Figure/Enterprise official website

An Conghui, CEO of Extreme Smart Technology, once said, "If there is no benchmark in the early stage, as a follower, it is not enough to be the same as others. Only by surpassing others can everyone think that you are a little competitive."

　

In creating differentiation, we can’t follow suit. With other car companies, we choose to focus on a large number of similar models in the same field, and seek market differences through the way of "having more children and fighting", and set up benchmark products in different market segments through excellent product strength, which is a very embarrassing product planning concept.

　

After the pre-sale of Krypton 007 started for 30 minutes, the booking volume exceeded 5,000; After 3 hours, the booking volume exceeded 10,000; After 48 hours, the booking volume exceeded 20,000.

　

The release of Krypton 007 not only enriches Krypton products, but also enters the pure electric luxury car market with the product experience of innovating the mainstream car market in the electric age, providing users with more and more novel category choices.

　

Text/Liu Chang

Editor Jiang Fan

Proofread Liu Baoqing

CCTV News:Live e-commerce is a new e-commerce retail model that has developed rapidly in recent years. It has the characteristics of strong interaction, high conversion rate, low access cost, and breakthrough in operating time and space constraints, providing consumers with a richer, more intuitive and vivid instant consumption experience. Relevant experts said that the healthy development of the live broadcast cargo industry, in addition to the industry’s own efforts, is also inseparable from the relevant market supervision.

Relevant data show that by the end of December 2022, there were 751 million webcast users in China. In the first half of 2023, the cumulative live broadcast sales of e-commerce platforms monitored by the Ministry of Commerce reached 1.27 trillion yuan, with about 110 million live broadcasts and over 2.7 million active anchors, which played an important role in promoting consumption, increasing employment and entrepreneurship, and promoting economic growth.

Wu Changhong, chief economist of Hangzhou Municipal Bureau of Commerce:When the anchor is broadcast, it measures whether the goods are liked and recognized by consumers through consumers’ reaction to the anchor. Therefore, the anchor is actually a "touchstone" to understand consumers’ needs. Let enterprises know what consumers like, and also create some new and good products.

The proportion of live broadcast e-commerce in online shopping continues to rise, while the proportion of live broadcast with goods by anchors in online celebrity is declining, while the proportion of store broadcast with brand promotion is increasing. Diversified development enriches and prospers the ecology of live broadcast e-commerce and contributes to the long-term development of live broadcast e-commerce industry.

Qi Yunlan, Deputy Director of Research Office of Market Economy Research Institute of the State Council Development Research Center:Consumers’ behaviors, concepts and consumer groups are constantly iterative, and consumption behaviors and consumption patterns, behaviors and concepts are also constantly developing. Any kind of innovation or a new model must be produced because it has its own competitiveness or is more in line with the requirements of the new era, the new economic environment and the demands of new consumers, so that it can grow, prosper and develop rapidly.

Relevant experts said that at present, the most important thing is how to further standardize the live broadcast e-commerce market, put an end to false propaganda and exaggerated propaganda, protect consumers’ rights and interests, create an honest market environment, enhance the sustainable development ability of live broadcast e-commerce, and better promote consumption growth and expand employment and entrepreneurship.

Qi Yunlan, Deputy Director of Research Office of Market Economy Research Institute of the State Council Development Research Center:The combination of state supervision, industry self-discipline and social supervision, I think, should enable any industry to move towards an increasingly standardized development path.

"Live+"empowers the real economy and stimulates new vitality of consumption

With the rise of live e-commerce in various industries, in recent years, the "talent" who creates content on the short video platform is very popular with consumers. Many industries, scenic spots, villages and other "content talent" have joined the live broadcast, and "live broadcast+traditional industries" have set off a new consumption format.

After graduating from Wu Mengting University, I began to work as a tour guide. At the beginning of this year, she began to try to combine the live broadcast with the tour guide’s explanation and broadcast the explanation in the scenic spot. In two months, the number of fans reached more than 4,000.

Anchor Wu Mengting:For you, it’s more efficient, and it won’t be so blind for the tourists who come. They have already got an understanding of (the destination) through my live broadcast room.

In a scenic spot in Shangrao, Jiangxi, the person in charge told the reporter that after the live broadcast was launched, some "private customization" needs were often received, and the business scope of the scenic spot continued to expand.

Wei Meng, Brand Director of Wangxian Valley Scenic Spot in Shangrao City, Jiangxi Province:After a live broadcast, we can show a variety of product content and experience projects to the audience in a down-to-earth manner. The audience perceives trust in online interaction, which can’t be satisfied by other forms of advertising and promotion. Therefore, we see that more and more users are diverting from online live interaction to offline tourism consumption.

The interactive introduction of "live broadcast+tourism" in the live broadcast room can directly understand the demands of tourists, thus providing corresponding tourism services and promoting relevant information, and attracting consumers’ participation more directly.

Tourist Ms. Huang:Sometimes the introduction of the live broadcast room is intuitive and interactive, which saves a lot of time to do raiders. I would rather watch the local live broadcast when I travel.

Not only that, the live video broadcast has also been integrated into the development of rural economy.

The video is being filmed by the Gaoji family in Huanghualing Village, Wushan Street, Wangcheng District, Changsha, Hunan Province. The appearance of short videos has turned this authentic farmer who used to only farm and work into a well-known local live broadcast carrier. The wife is the chef, the mother is the chef, the younger sister is the side dish, and a few special dishes are fried on the spot. The family has a tacit understanding and a happy state, which also allows them to find their own position in the traffic of the Internet. In two years, Gao Jijia’s account released 216 videos and more than 400 live broadcasts, and the appearance of live broadcasts changed their family’s life.

Villagers’ Gaoji in Huanghualing Village, Wushan Street, Wangcheng District, Changsha, Hunan Province;My bigger dream is to drive the agricultural and sideline products (sales) of local small agricultural enterprises and drive these daily incomes of farmers.

With the successful case of Gaoji, the local government also encourages everyone to actively explore new formats and new scenarios under "live broadcast+"and cultivate a number of new accounts. The local government also actively strives for policies for everyone in terms of express logistics, goods with goods, etc., reducing logistics costs and achieving a double harvest of live broadcast and local economy.

Yong Jia, Director of the Network Information Office of Wangcheng District Committee, Changsha City, Hunan Province:Many ordinary people are both producers and sellers. Through the combination of these two businesses, the goal of getting rich for the masses, industrial development and rural revitalization is finally realized.

Nowadays, live broadcast and short video are vivid portrayal of "integration of numbers and reality". With the platform as a link, it pulls both ends of supply and demand and opens up a new "track" for the efficient circulation of industrial products and agricultural products. The data shows that in 2022, the direct or indirect employment opportunities driven by the live broadcast and short video industries exceeded 100 million.

Report from Jiwei. com (Text/Dusha) Following the official announcement of the "Xiaomi Automobile Technology Conference" on December 25th, Lei Jun has written more than one eye-catching essay a day, and on December 27th, he also published a sincere tribute blog post: "We are well aware of the complexity of the automobile industry, and we are well aware of the hard-won development, and sincerely pay tribute to pioneers such as BYD, Weilai, Tucki, Ideality and Huawei", and in Beijing and Shanghai.

At 14 o’clock on the afternoon of December 28th, 1003 days after the announcement of entering the smart electric vehicle industry, the first press conference of Xiaomi Automobile was finally grandly opened. Although as early as December 25, Xiaomi Auto officially said that this conference only talked about technology, not products. However, at the press conference site, the "pre-press conference" of Xiaomi SU7 was also held simultaneously, involving product information including appearance, interior, space, power and safety. The first car is positioned as a "C-class high-performance eco-technology car" to achieve the ultimate performance of high performance, eco-technology and smart space experience, and to build the first choice of the elite of the times and the top benchmark of science and technology and humanities.

Because the release of Xiaomi car will take several months, the price that has attracted much attention has not been announced, but according to the configuration and information disclosed intentionally or unintentionally, Lei Jun’s words are proved, "Xiaomi SU7 is indeed a bit expensive, but it makes sense", and the scene has been compared with Porsche Taycan Turbo and Tesla Model S. When talking about the configuration of power batteries at the scene, Lei Jun quipped that the cost of the 101-kilowatt-hour power batteries currently carried is more than 100,000, and the price of similar power systems on the market is more than 400,000, so 149,000 is impossible. In fact, judging from the portrait of Xiaomi SU7 configuration, its price is hard to be lower than 200,000.

Then, before the official price is further announced, let’s take a look at what black technologies Xiaomi SU7 is equipped with.

At the whole press conference, Lei Jun unveiled five core technologies, including electric drive (motor), battery, large die casting, intelligent driving and intelligent cockpit.

Xiaomi Automobile Motor overtook Tesla, and the established Xiaomi Super Motor Project has an expert team of more than 100 people, and cooperated with suppliers such as Huichuan. At the same time, by using AI technology, it successfully developed a motor with a speed of 21,000 at the end of 2022, surpassing Tesla. At this stage, the millet motors V6 and V6s have been mass-produced, and the first millet car will be equipped with the millet motors V6 and V6s, with performance comparable to Porsche and Tesla.

What’s more, Lei Jun released the third motor V8s developed by Xiaomi at the scene, with a speed of 27,200. It is also the top motor in the world at present, and its rotor is made of ultra-high strength silicon steel, which will get on the bus in 2025.

In terms of batteries, Xiaomi launched the 871V silicon carbide high-voltage battery pack jointly developed by thousands of people with Contemporary Amperex Technology Co., Limited, which took two years to overcome many difficulties, and Xiaomi built its own battery pack factory. At the same time, in order to ensure battery safety and improve vehicle efficiency, we developed the world’s first CTB battery inversion technology, designed it according to the most stringent battery safety standards, and equipped it with powerful thermal management technology, with the goal of "challenging the king of batteries in winter".

Since Tesla started the large-scale die casting, this wave has quickly swept the entire automobile industry. Xiaomi Automobile also hopes to reshape automobile manufacturing with industrial behemoths, and launch super die-casting of Xiaomi, reaching the maximum locking force of 9,100 t, exceeding the locking force of 9,000 t in Tesla’s newly completed factory in the United States. The driving force of industrial behemoths often comes from the innovation of the underlying materials. Therefore, Xiaomi independently developed Titan alloy materials, which is also the only car factory in China that has mass-produced self-developed alloy materials. Based on innovative technology, it introduced the 72-in-1 integrated die-casting floor, which reduced the welding points of the whole car by 840, reduced the noise in the car by 2dB and reduced the weight by 17%.

In the field of intelligent driving, the industry is particularly involved at present. Lei Jun bluntly said that Xiaomi is not afraid of rolling, and it is from small to large. Xiaomi’s goal is to enter the first camp in the industry in 2024. Its strength stems from Xiaomi’s self-developed intelligent driving technology and three outstanding advantages. One is to insist on long-term investment. The total investment of Xiaomi in the first phase is 3.3 billion, which has been increased to 4.7 billion. The scale of the exclusive team exceeds 1,000, more than 200 vehicles have been put into test, and the test mileage exceeds 10 million kilometers. The second is the comprehensive empowerment of AI: Xiaomi AI Lab was established in 2016. After seven years of development, it currently has 3,000 AI engineers; The third is the self-developed underlying algorithm: Xiaomi’s new generation technology platform, which has BEV+Transformer+ occupation network and is fully integrated into the big model.

Perception has always been the key in intelligent driving. In order to break through the difficult problems in perception, adaptive zoom BEV technology, large road model and super-resolution occupation network technology constitute three key technologies of Xiaomi intelligent driving. These technologies can support a comprehensive leap in terms of visibility accuracy, perception accuracy and control accuracy, making cars "visible, accurate and understandable", making high-speed and urban intelligent driving more accurate and safer, and solving the existing problems of urban NOA, such as difficulty in crossing intersections.

In terms of hardware, the intelligent driving system is equipped with top-level configuration, including two NVIDIA Orin high computing power chips, with a comprehensive computing power of 508TOPS. The sensing hardware includes 1 lidar, 11 high-definition cameras, 3 millimeter-wave radars and 12 ultrasonic radars (Max version).

What’s more worth mentioning is that Xiaomi’s self-developed world’s first mass-produced end-to-end "perceptual decision-making model" has shown amazing strength in application scenarios such as mechanical warehouses. It combines perception-decision algorithm, real-time observation and dynamic adjustment of large models, which is the first time in the world to apply this technology to production vehicles.

As a field that Xiaomi is good at, the intelligent cockpit is also the last link of its strategy of "people and cars are all ecological". After 13 years of exploration, the Xiaomi 澎湃 OS developed in 7 years is highly anticipated for the first time. Based on Xiaomi 澎湃 OS, Xiaomi has built a unified visual interaction system, realizing a comprehensive sharing ecosystem from software to hardware. Through a series of bottom reconstruction such as intelligent cockpit, Xiaomi has laid a solid foundation for the evolution of cars.

Xiaomi’s intelligent cockpit adopts a "people-centered" interactive architecture, and is equipped with a 16.1-inch 3K ultra-clear central control panel, a 56-inch oversized HUD head-up display, a 7.1-inch flip instrument panel, and Xiaomi Pad, which can realize five-screen linkage. At the same time, in order to support the silky experience of the intelligent cockpit, Qualcomm Snapdragon 8295 cockpit chip is equipped.

Ecology is the key word of Xiaomi cockpit system. The intelligent cockpit has a strong application ecology, and the Xiaomi tablet application ecology can seamlessly get on the bus. At the same time, the mobile phone application Pin can be applied to the car, and the native application of the car can be changed in seconds. In addition, the Xiaomi cockpit system supports hardware ecological boarding, including the Mijia ecological non-inductive boarding, the central control large screen can be expanded, the center console can be expanded, and the seat back can be expanded.

Xiaomi also opened a unified standardized interface and enriched standard protocols, creating the strongest exclusive CarIoT ecosystem. The built-in CarIoT docking station supports the changeable access of a series of devices, including smart fragrance. Four groups of Pin point power supply communication design can expand physical keys. In order to meet the needs of Apple users, Xiaomi fully supports wireless CarPlay car, and provides exclusive accessories and exclusive applications for iPad on the rear expansion screen.

When it is about to close in 2023 and friends are fighting for the high-end smart electric market of 400,000 and above, Xiaomi Automobile will release Xiaomi SU7 real car with a vision. Lei Jun said that the automobile industry has been more than 100 years, and there is no shortcut to the track for a hundred years. Xiaomi decided to invest ten times, start with the underlying core technology, seriously build a good car, and through 15 to 20 years of efforts, become the top five automobile manufacturers in the world, and strive for the all-round rise of China’s automobile industry.

However, it is conceivable that when Xiaomi enters the automobile market, the challenges it faces are greater than those of the previous new car-making forces, and the competition in each segment of the track can be called bloody rain. In 2024, the price war is expected to continue in the industry. Therefore, when Xiaomi comes, it is bound to face the quagmire of price scuffle, and the longer-term problem for Xiaomi is, where is the market position? (Proofreading/Zhu Zhilei)

In the car home Haikou preferential promotion channel, we can see a high-profile car model-a preferential activity is under way. The starting price of this model in Haikou area is 390,900 yuan, and the highest discount is 135,000 yuan. If you are interested in this model, you can click "Check the car price" in the quotation form to get a higher discount.

The design of Volvo XC60 new energy is unique, and the front face design is fashionable. The car adopts a unique air intake grille design, which makes its overall style more refined. The body lines are smooth and full of strength. As a new energy vehicle, Volvo XC60 New Energy also has a unique logo and detailed design to show its environmental protection characteristics. The overall style is simple and generous, showing Volvo’s consistent high quality and elegant temperament.

Volvo XC60 new energy vehicle is a medium-sized SUV with a body length of 4708mm, a body width of 1902mm, a body height of 1656mm and a wheelbase of 2865 mm.. The car uses 255/45 R20 front and rear tires, with fashionable rim style and high visual impact. The body lines are smooth and exquisite, especially the design of the side lines is unique, which shows the perfect combination of luxury and sportiness. The front wheel track is 1649mm and the rear wheel track is 1653mm, which makes the vehicle more stable and better in handling.

The interior design of Volvo XC60 New Energy is simple and elegant, with attention to detail and texture. The steering wheel is made of leather, which can be manually adjusted up and down and back and forth, so that drivers can easily find the driving posture that suits them best. The central control screen has a size of 9 inches, supports voice recognition control system, and can control functions such as multimedia, navigation, telephone and air conditioning. The front and rear rows are equipped with USB/Type-C interface, which is convenient for users to charge. The front seats are also equipped with heating function, and both the driver’s seat and the co-pilot seat support power seat memory. In addition, the seat can be adjusted in front and back, backrest, height, leg rest and lumbar support to provide a comfortable riding experience. The rear seats support proportional reclining, and the space can be flexibly adjusted as needed.

Santana is a classic car with reliable quality and excellent performance. It has a maximum power of 228 kW and a maximum torque of 400 N m. It is equipped with a 2.0T 310 HP L4 engine, which provides a strong power output. At the same time, it is equipped with an 8-speed automatic gearbox, which can shift gears smoothly and quickly, making driving more comfortable. Whether on urban roads or highways, Volvo XC60 new energy can bring excellent driving experience.

As a luxury SUV, Volvo XC60 New Energy not only shows a unique design style in the appearance of the whole vehicle, but also performs well in the interior, performance and safety. Car home car owners’ evaluation of it is also very pertinent. He mentioned that although the removal of the tail throat made the back look a little bald, it was still acceptable. In addition, 24 wheels have been changed into low wind resistance shapes. Although some people don’t like them, they also have a sense of science and technology, which complements the overall style. It can be seen that the details and overall style of Volvo XC60 new energy have been recognized and affirmed by the owners. Whether on urban roads or highways, this model can provide excellent driving experience and safety guarantee. Therefore, for those consumers who pursue luxury, comfort and safety, Volvo XC60 new energy is undoubtedly a worthy choice.

Shenzhen News Network August 29, 2023(Reporter Ye Mei) On August 27th, the "828 B2B Enterprise Festival Huawei Cloud Innovation Center Ecological Development Forum" was held in Shenzhen. The theme of this forum was "Empowering industries to integrate innovation", focusing on enterprise digitalization and exploring the path and vision of enterprise digital transformation.

At the meeting, Huawei Cloud Innovation Center joined hands with more than 10 software eco-partners to release the special plan of Huawei Cloud Industry Expert Group. UFIDA Software and Huawei Cloud released the Fast by BIP product scheme, and CITIC Bank Shenzhen Branch and Huawei Cloud jointly launched CITIC e-loan financial products for software partners. Huawei Cloud Empowerment Cloud and the National Service Alliance for Digital Transformation of Small and Medium-sized Enterprises jointly released the National Alliance for Digital Services of Small and Medium-sized Enterprises "Three Fu" National Bank-Shenzhen Station. In addition, the awarding ceremony of Huawei Cloud Innovation Center’s excellent education solution partner and Huawei Cloud Innovation Center’s excellent manufacturing solution partner was held at the same time.

Digital transformation experts from many industries shared the digital transformation of manufacturing and education industries, as well as the cooperation history and achievements with Huawei Cloud Innovation Center.

Gather wisdom and strength to help enterprises transform digitally and win a new future for industrial development.

Liu Yaohuang, Party Secretary and Director of Shenzhen Pingshan Industry and Information Technology Bureau, delivered a speech at the scene. He thanked Huawei and partner companies for their support to Pingshan’s economic and social development, and introduced the achievements of digital transformation of Pingshan’s manufacturing industry. He said that Pingshan has always insisted on planning, exploring and promoting the development of "digital+"empowerment, intelligence and assignment manufacturing, and promoting the real economy to improve quality, increase efficiency and reduce costs. The N of Pingshan industrial policy "2+N" includes the special policy of digital economy, which highlights the strong support for the industrial Internet.

Zhiqiang Tao, vice president of Huawei Cloud China District, shared the theme of "Gathering wisdom, gathering strength, and sharing a new chapter of booming industrial ecology". He said that "empowering industries and integrating innovation" is the core of Huawei Cloud Innovation Center. With the help of integrating innovative public service platforms, it provides a complete set of technical empowerment solutions related to all aspects of digital ecology, helping enterprises solve the technical, financial and talent problems faced in the transformation and helping enterprises grow better. In the future, Huawei Cloud will continue to practice the concept of "everything is service", continue to increase investment in the fertile soil of industrial digital innovation, and join hands with governments at all levels, enterprises, ecological partners and developers to jointly develop, tolerate and innovate a new chapter in industrial ecology.

Peng Kunmin, general manager of Huawei Cloud Empowerment Cloud Excellence Operation, gave a speech entitled "Gathering together, working together for a win-win situation, and the road of Huawei Cloud Empowerment Cloud Digital Intelligence Empowerment", which explained the development trend of digital economy and the development process of Huawei Cloud Empowerment Cloud. He said that digital transformation has become an important direction of industrial development. Huawei Cloud Empowering Cloud continues to build an eco-service organization, strengthen the introduction of eco-partner capabilities, and with the help of the public service platform model of Huawei Cloud Innovation Center, it continues to empower enterprises in digital transformation and accelerate the digital innovation of the industry for industrial manufacturing, software development, integration of industry and education and other industry scenarios.

At the inauguration ceremony of Huawei Cloud Partner Expert Group, Chen Qianwen, general manager of inclusive finance Department of CITIC Bank Shenzhen Branch, Tang Xianyong, deputy general manager of Shenzhen Xunfang Technology Co., Ltd., Liu Chen, co-founder and vice president of Beijing Yidong Fanxiang Technology Co., Ltd., Wang Pei, chairman of Shanghai Zhenyun Information Technology Co., Ltd., Zhang Yancong, founder and &CEO of Guangzhou Shengyuancheng Technology Co., Ltd., and Zhou Haiwei, chief technology officer of Shanghai Yurui Information Technology Co., Ltd. Wang Zhiwei, Vice President of Ecology of Shanghai Black Lake Technology Co., Ltd., and Ma Changxi, General Manager of South China Operation Center of Shanghai Pan Micro Network Technology Co., Ltd. became members of the expert group. Zhiqiang Tao, Vice President of Huawei Cloud China District, and Peng Kunmin, General Manager of Huawei Cloud Empowerment Cloud Excellence Operation presented letters of appointment to the members of the expert group and took a group photo.

Huawei Cloud Innovation Center joins hands with eco-partners to create heavy activities, invest superior resources and boost the digitalization of the industry.

Cloud gathers innovation and prospers ecology. In the process of promoting the digital development of the industry, Huawei Cloud Innovation Center cannot do without the support of excellent partners. In this forum, Huawei Cloud Innovation Center and ecological partners released a number of projects to accelerate the digital transformation process of the industry.

Fast by BIP, a large-scale enterprise digital intelligence package jointly built by UFIDA Network Technology Co., Ltd. and Huawei Cloud, provides a one-stop global service for large enterprises, enabling customers to make good use of the cloud and help them quickly promote digital intelligence and become a digital intelligence enterprise. In this forum, Zhiqiang Tao, Vice President of Huawei Cloud China, Gao Feng, Minister of Huawei Cloud Ecological Development Department, Dong Bo, Vice President of UFIDA Network and President of UFIDA Ecological Department, and Wang Zengliang, Director of UFIDA Network Ecology jointly announced that "2023 UFIDA Fast by BIP & Huawei Cloud Joint Product" was officially released.

CITIC Bank Shenzhen Branch and Huawei Cloud launched the "e-loan for cloud merchants" to help enterprises build a lifeline and empower their partners to grow their businesses. Under the witness of Zhiqiang Tao, Vice President of Huawei Cloud China, Peng Kunmin, General Manager of Huawei Cloud Empowerment Cloud Excellence Operation, Chen Qianwen, General Manager of inclusive finance Department of CITIC Bank Shenzhen Branch, and Luo Wenqiang, Deputy General Manager of State-owned Assets Business Department of CITIC Bank Shenzhen Branch, the "2023 Cloud Business E-Loan Huawei Cloud Innovation Center Accelerated Action" was officially released.

The National Alliance of Digital Services for Small and Medium-sized Enterprises "Sanfu" National Tour-Shenzhen Station was officially launched.

Qi Lu, Secretary-General of the National Alliance for Digital Services of Small and Medium-sized Enterprises, introduced the "three contributions" of the National Alliance for Digital Services of Small and Medium-sized Enterprises, namely, promoting digital empowerment, intellectual empowerment of scientific and technological achievements, and brand assignment of quality standards-Shenzhen Station.

Under the joint witness of Peng Kunmin and Qi Lu, the activity of "National Alliance of Digital Services for Small and Medium-sized Enterprises’ Three-Fu National Tour-Shenzhen Station" was officially launched.

The forum also presented awards and awards for Huawei Cloud Innovation Center’s outstanding educational solution partners, Huawei Cloud Innovation Center’s outstanding manufacturing solution partners, Huawei Cloud Innovation Center’s outstanding general solution partners and Huawei Cloud Innovation Center’s potential partners.

In the future, Huawei Cloud Innovation Center will continue to join hands with ecological partners, continue to serve enterprises, deeply empower the industry, accelerate the integration of innovation, and help the process of digital intelligence transformation.

[car home Jinhua Preferential Promotion Channel] Good news, preferential promotion activities are being carried out in Jinhua area! The current maximum discount for this model is 13,000, and the minimum starting price is 113,900. If you are interested in this model, you may wish to click "Check the car price" in the quotation form to get a higher discount.

Tiggo 8 PRO is a medium-sized SUV, and its design is very fashionable and dynamic. The front part of the car adopts a large-area air intake grille, with sharp LED headlights and fog lights, creating a very domineering visual effect. The body lines are smooth and strong, and the overall style is very tough. The side of the car body is decorated with smooth lines and chrome plating, which makes the car body more exquisite. Through taillights are used in the rear part, which makes the whole rear look very fashionable. In addition, the Tiggo 8 PRO is also equipped with 18-inch wheels to make the whole car look more stable. On the whole, the design of Tiggo 8 PRO is excellent, which is not only fashionable and dynamic, but also very powerful, which is very in line with the aesthetic needs of modern consumers.

Tiggo 8 PRO is a medium-sized SUV. Its body size is 4745mm long, 1860mm wide and 1745mm high, with a wheelbase of 2710mm and front and rear wheel tracks of 1582mm and 1604mm respectively. The lines on the side of the car are smooth, showing a tough and fashionable feeling as a whole. Before and after tyre size are the same, both are 235/55 R18. Tire brands can choose different brands and models to meet different driving needs. In addition, the rim style of the Tiggo 8 PRO is also very unique, adopting a multi-spoke shape to make the vehicle look more dynamic. In short, the side design of the Tiggo 8 PRO is simple and atmospheric, which shows the strength and stability of the medium-sized SUV.

The interior design of the Tiggo 8 PRO is full of modernity. The central control screen size is 12.3 inches. It is equipped with a voice recognition control system, which can easily control multimedia systems, navigation, telephones, air conditioners and skylights. The steering wheel is made of leather and supports manual up and down+forward and backward adjustment, so that the driver can easily find the most comfortable position. The front and rear rows are equipped with USB and Type-C interfaces, which is convenient for passengers to charge. The front row is also equipped with a mobile phone wireless charging function. The seat is made of imitation leather. The main seat supports front-back adjustment, backrest adjustment and height adjustment (2-way), and the auxiliary seat also supports front-back adjustment and backrest adjustment. The second row of seats supports backrest adjustment, and the rear seats can also be tilted in proportion, which increases the practicability of the vehicle.

The Tiggo 8 PRO is equipped with a 1.6T 197 HP L4 engine with a maximum power of 145kW and a maximum torque of 290N·m, and is equipped with a 7-speed wet dual-clutch gearbox. This engine has excellent performance and can provide strong power output for vehicles. At the same time, the addition of 7-speed wet dual-clutch gearbox also provides drivers with a smoother shift experience.

In the eyes of car home car owners, the design of Tiggo 8 PRO is excellent, which is not inferior to other models of Chery in recent years. He believes that the design of the Tiggo 8 PRO has high aesthetics, especially the black body, which gives people an atmospheric feeling. However, he also mentioned a problem that needs attention, that is, the black body is easy to get dirty. Overall, the owner is satisfied with the design of Tiggo 8 PRO. We believe that with the use and evaluation of more car owners, the reputation of Tiggo 8 PRO will become more and more rich and true, and it will also provide consumers with more car purchase references.

　 　 　 　Luo Jing, the host of the famous News Network, Cindy Lee, the actor who plays Fang Yu in Deep Rain, and Fuck off! Tumor jun touched many netizens’ cartoonist Xiong Dun … In recent years, many celebrities have passed away because of lymphoma. At the same time, however, there are also many famous people who have succeeded in fighting cancer after suffering from lymphoma. For example, the 70-year-old famous director Wu Yusen was diagnosed with large B-cell lymphoma in tonsils when filming Taiping Wheel in 2008. After four operations, in the second month of chemotherapy, his mouth was all festered, he could not swallow, and his body and face were so thin that he was wrinkled. Finally, he succeeded in fighting cancer with his firm will! 　

　 　 　 　For example, Kai-Fu Lee, the founder of an innovative factory that successfully used chemotherapy and targeted therapy to fight advanced lymphoma! On September 5, 2013, 52-year-old Kai-fu Lee announced that he had stage IV follicular lymphoma and had to leave work for treatment. In February 2015, he announced the results of his physical examination, indicating that the tumor in the body is not obvious at present. In June of the same year, Kai-fu Lee said that he had not found any lesions in his last two examinations and ridiculed himself as "Li Kangfu". It took Kai-fu Lee less than two years from finding out the cancer until the focus was completely gone. His anti-cancer experience is worth learning from.

Alias "the most disguised disease", lymphoma has become a killer.

　 　 　 　According to statistics, there is a new case of lymphoma every 9 minutes in the world. The incidence of lymphoma in China is 0.02‰, with about 25,000 new patients and nearly 20,000 deaths each year. The threat of lymphoma is rapidly emerging. It ranks among the top ten malignant tumors in China and ranks second among hematological malignancies. At the beginning, the symptoms of the disease were hidden, and it was described as "the most disguised disease". In the intercontinental area, the incidence of non-Hodgkin’s lymphoma is much higher than Hodgkin’s disease, which is about 9: 1. Because of the higher degree of malignancy and worse prognosis, lymphoma is generally referred to as non-Hodgkin’s lymphoma. In China, the incidence of malignant tumors ranks ninth among men and tenth among women. Non-Hodgkin’s lymphoma can occur in all ages, and the high incidence age is 45~60 years old. Among them, Luo Jing suffered from diffuse large B-cell lymphoma (DLBCL). This is a common non-Hodgkin’s lymphoma, which belongs to aggressive lymphoma with high malignancy. The course of the disease progresses rapidly. If it is not actively treated, the median survival time is less than one year. In recent years, great progress has been made in the research and treatment of lymphoma, and new drugs and technologies have risen strongly! CAR-T therapy Among them, the chimeric antigen receptor T(CAR-T) cell therapy is particularly prominent. Its appearance represents a great progress in personalized cancer treatment, especially bringing the hope of rebirth to patients with hematological malignancies.

Complete remission! The first advanced lymphoma patient in China who received CAR-T therapy was discharged smoothly!

　 　 　 　Although they all suffer from diffuse large B-cell lymphoma, Mr. Chen, who suffers from malignant lymphoma, is a lucky one. According to Jiangsu public news channel News Space Station, on August 31st, the first lymphoma patient treated with CAR-T cells in China achieved complete remission and was discharged smoothly. 　

　 　 　 　Mr. Chen suffered from diffuse large B-cell lymphoma. After the onset of the disease in October 2010, he had received chemotherapy for many times, but all of them were unsatisfactory. Diffuse large B-cell lymphoma is the most common malignant lymphoma. After immunotherapy, about 60% patients can survive for a long time, but 40% patients will still relapse. In June this year, Mr. Chen accepted CAR-T cell therapy with a tentative attitude, and all the physical indicators tended to be normal. He told reporters with delight that his physical condition was better than before, and he was no different from a normal person after leaving the hospital. CAR-T therapy, a "living drug", made her completely relieved and looked forward to a cancer-free future.　

　 　 　 　As a "living" drug, CAR-T therapy is very different from traditional drugs. First, the therapy needs to isolate T cells from patients and modify them with chimeric antigen receptor (CAR) in vitro, so that they can specifically recognize cancer cells. Finally, the modified T cells are expanded and reinfused into patients. Compared with traditional chemotherapy and hematopoietic stem cell transplantation, it can kill tumor cells more accurately, improve the curative effect and greatly reduce the side effects. 　

The well-known director of hematology in China said: CAR-T can identify lymphoma very deliberately, and the antigen carried on tumor cells will attack directly after being connected, and it will produce an anti-tumor effect and kill it directly without the need for second signal stimulation, so one of its characteristics is accuracy, and the second is power. The scope of application is still the recurrence or refractory diffuse large B lymphoma that is ineffective in general immunochemotherapy. 　

CAR-T therapy FDA approved 6 models, and domestic CAR-T therapy caught up! 　　　

　 　 　 　After sharing the above news reports about CAR-T therapy, let’s get down to business and talk about CAR-T therapy. At present,CAR-T therapy has achieved great success in the treatment of hematological malignancies.. Six CAR-T cell therapies have been approved by FDA in the United States and two CAR-T cell therapies have been listed in China. The picture below shows CAR-T cell therapy that has been listed at home and abroad. 　 　　

　 　 　 　Although China’s CAR-T technology started late, the domestic market is large. According to the data on Clinicaltrials.gov’s website, China became the country that registered the most CAR-T tests in September 2017. As of May 27th, 2021, there are 1301 CAR-T clinical trials in the world, and the number of CAR-T trials registered in China has reached 478!　

01　　The first CAR-T therapy in China was approved for listing! China welcomes the first year of cellular immunotherapy.

　 　 　 　On June 22nd, the blank in the field of CAR-T in China was finally broken! The latest announcement of China National Medical Products Administration (NMPA), Fosun Kaite Biotechnology Co., Ltd. (hereinafter referred to as " Fosun Kate ”） The CAR-T cell therapy product targeting CD19, Aquilencel Injection (also known as Aquilencel, FKC876), was officially approved for marketing. This is the first approved CAR-T therapy in China and the sixth approved CAR-T therapy in the world. It is believed that China will usher in the blowout era of CAR-T cell therapy.　

02　　In just one month, the second CAR-T therapy in China and the sixth CAR-T therapy in the world were approved!

　 　 　 　On September 3, the State Drug Administration recently announced that Yaoming JunuoThe CAR-T product targeting CD19, Regiosai Injection.(relma-cel, trade name: Benoda) has been officially approved. The approved indications for Regioside Injection are:It can be used to treat relapsed or refractory large B-cell lymphoma (r/r LBCL) in adult patients after second-line or above systemic treatment.Reggiorense injection is the second CAR-T product approved in China and the first CAR-T product of Class 1 biological products in China.

　

It’s only been about one month since it was submitted for examination and approval on July 30th last time, which can be described as rapid progress. Congratulations! (At present, patients with economic conditions can contact cancer-free homes for the treatment of regiorense. )　

Boom! The first BCMA CAR-T therapy in China and the second in the world was approved by FDA!

　 　 　 　China’s "dark horse" in CAR-T cell therapy industry-legendary BCMA(B-cell mature antigen) CAR-T therapy Cedar-B38m/JNJ-4528 (hereinafter referred to as cilta-cel) has attracted much attention, and has shown excellent anticancer activity in clinical trials for multiple myeloma.

　 　 　 　What is exciting is that on February 28th, 2022, local time, it was jointly developed by Janssen and Legendary Biology.BCMA CAR-T product, Cedactylosin (trade name Carvykti), has been approved by the US FDA for the treatment of adult patients with relapsed/refractory multiple myeloma (MM).

This is the first cell therapy product approved by FDA in China and the second CAR-T cell immunotherapy approved for BCMA in the world.

　

　 　 　 　Cilta-cel was awarded priority review qualification by FDA on May 26th.However, the approval of the West Dachiorensai was delayed, and it was adjusted from November 29, 2021 toFebruary 28, 2022Fortunately, it was finally approved and lived up to expectations!

　 　 　 　cilta-celIt is a CAR-T therapy directed by research B cell maturation antigen (BCMA), which is used to treat relapsed or refractory multiple myeloma (RRMM). These patients received an average of five kinds of pre-treatment before treatment, 76% of them received five kinds of treatment, and 86% of them were resistant to five kinds of treatment, including CD38 treatment, and they were both resistant to protease inhibitor PI and immunomodulator IMiD. Simply put, it is refractory to relapse and lack of effective treatment in the follow-up. The principle of this CAR-T therapy is different from the current PD-1/L1. It directly uses the T cells in the patient’s body, transforms them in vitro, replicates them in large quantities, and then transfuses them into the patient’s body to kill cancer cells. At the ASH conference in 2021, the latest results of the 1b/2 CARTITUDE-1 study (n=97) showed that,meso-position 22 months Long-term follow-up, The objective remission rate (ORR) reached 98% , 83% patients achieved strict complete remission (sCR) It is emphasized that the mitigation will deepen with the passage of time (sCR will increase from 67% reported at the ASH annual meeting in 2020 to 83%). At 18 months, 66% of the patients were alive and the disease did not progress. .The two-year progression-free survival rate and overall survival rate are respectively 61% and 74% .The latest research results to be announced at the ASCO annual meeting in 2021 show that After a median follow-up of 18 months, the overall survival (OS) rate was 81%. The remission rate is comparable in all pre-specified subgroups and patients with different treatment lines.

　　 　

American research shows that cilta-cel has excellent long-term efficacy.　 　

　 　 　 　Emily, a foreign country, successfully ushered in nine years of cancer-free survival in 2021, and suddenly became the "spokesperson" of global CAR-T therapy. In China, there is such a lucky person whose fate has been completely changed by CAR-T therapy. Mr. Min was diagnosed with a special rare disease at the age of 54- multiple myeloma . He had no drugs available at that time, so he was lucky enough to participate in the clinical trial of CAR-T therapy. Although the treatment process was not smooth sailing, after three times of treatment, all the lumps on Mr. Min’s body disappeared and the pain disappeared. Surprisingly, by June 4, 2021, Mr. Min had lived cancer-free for five years, which is the field of cancer treatment, which is theoretically said. Clinical cure .

　 　 　 　In fact, as early as March 27th this year,The FDA approved the first CAR-T therapy targeting BCMA for adult patients with relapsed/refractory multiple myeloma (r/r MM) after receiving more than four therapies.

　 　 　 　Chemotherapy to fight cancer is often "killing one thousand enemies and losing eight hundred". Antibody drugs can accurately find tumor targets, but sometimes their combat effectiveness is insufficient. If we can put a "warhead" of chemotherapy drugs on antibody drugs, can we attack cancer cells more accurately? Based on this, an ADC (antibody drug conjugate) called "biological missile" was born. Antibody-coupled drugs are like biological missiles, which consist of two core functions: the first is antibody (missile body), the second is strong chemotherapy drug (nuclear warhead); This design will enable antibodies to find tumor cells with chemotherapy drugs, and then accurately poison tumor cells and poison them. 　This drug design combines the precision of targeted drugs with the high efficiency of chemotherapy drugs, which not only avoids the toxic and side effects of systemic use of chemotherapy drugs, but also has stronger killing ability than using targeted drugs alone, killing two birds with one stone. 　 　 　 　

Schematic diagram of antibody-coupled drugs 　 Note: (a) General description of A)ADC structure; (b) the mechanism of B)ADC. 　

Fourteen ADC drugs have been approved around the world, which brings hope for prolonging the survival time of back-line patients.

　 　 　 　At present, more than 100 kinds of ADC are undergoing clinical trials. Most adcs have progressed from phase i to phase II. Some ADC phase III trials show positive results; Up to September 20th, 2021, there are 14 kinds of ADC drugs on the market in the world, which are mainly used in hematological tumors and solid tumors, and are mainly used for back-line treatment of patients, including advanced, recurrent/refractory and metastatic tumor indications.

　

Fourteen ADC drugs have been approved worldwide.

According to the curative effect data, ADC drugs have brought more treatment options and the hope of prolonging the survival time for back-line patients, and the objective remission rate or median progression-free survival time of several drugs has doubled compared with chemotherapy.

Looking at the CD30 target, the new drug F0002-ADC became an instant hit and squeezed into the lymphoma track.

　 　 　 　CD30, a member of tumor necrosis factor (TNF) receptor superfamily, can promote cell proliferation or apoptosis by activating different signal pathways. In 2020, Vebtuximab for injection (Adcetris) was approved to be listed in China, and CD30 became famous. Adcetris, as an antibody-coupled drug targeting CD30, has an effective rate of 73% for Hodgkin’s lymphoma (HL) and 86% for anaplastic large cell lymphoma (ALCL). It is the first new drug approved in the field of Hodgkin’s lymphoma treatment in recent 30 years, and it is also the first time that a drug targeting CD30 has been approved, filling the gap in this field. At present, the only new ADC drug for CD30 in China is F0002-ADC. This new drug consists of three parts, namely, human-mouse chimeric anti-CD30 monoclonal antibody, thioether linker (MCC) and DM1. Since the project was launched in 2016, it has been disappointing! At present, patients with recurrent/refractory CD30 positive peripheral T-cell lymphoma are being recruited clinically! This is a new treatment option for patients with recurrent/refractory peripheral T-cell lymphoma!

This article is original for a cancer-free home, and it needs authorization to reprint! Cancer-free homes remind patients 　

　　Since the beginning of January this year, residents of Weicheng Town, Guiyang City, located in the mountainous area of Guizhou Province, have often seen a drone shuttle through the town. Under the belly of the plane, there was a box with the words "China Post". The local people later learned that this drone was used by the post office in the town to deliver mail to the surrounding mountain villages. Beijing Youth Daily reporter learned from the local post office on the 15th that this drone now flies twice a week, and it will be promoted if it works well in the future.

　　Postman part-time drone operator

　　On the morning of 15th, Wang Hua, a staff member of Weicheng Post Sub-bureau in Guiyang, took his drone to an open space near the town, and prepared to deliver newspapers and some mails to five villages around the town.

　　Wang Hua is a postman. He used to ride a motorcycle to deliver mail to several surrounding villages three times a week. Because the mountain road is rugged, although the distance is not far, it takes a whole day to deliver it every time. Since the beginning of January this year, Wang Hua has added a new task, which is to operate drones to transport mail.

　　"Our economy is not developed here. Many people have never seen drones, so many people gathered around to see them when they first started flying. Some old people asked us about the timetable for flying drones and came to see them several times." Wang Hua said.

　　Wang Hua said that he is driving a drone, but in fact the main operation is not done by him. He is mainly responsible for loading mail on the drone and then checking the battery. The flight route has long been set by the company that developed the drone. All he has to do is scan the QR code on the plane with his mobile phone, and then click the start button on the mobile phone, and the plane can fly according to the pre-designed route.

　　"It used to take a whole day to send the mail from these villages by motorcycle. Now the whole route is flown by drones, which is more than an hour." Wang Hua said.

　　Flying to every village requires changing batteries.

　　Director Chen Zhongxiang of Weicheng Post Sub-office told the reporter of Beiqing Daily that at present, there is only one drone in the town post office, and they selected five villages, namely Yingyan, Yinqiao, Maixiang, Xingguang and Lianhua Temple, as delivery pilots. Chen Zhongxiang said that these villages were chosen because they are relatively remote, and it takes too long and the road is dangerous to send mail into the village by manpower.

　　Chen Zhongxiang said that the UAV they are using now has a diameter of more than 1 meter and six propellers. In theory, it can carry about 7 kilograms of goods. However, for safety reasons, the stipulated delivery weight is no more than 5 kilograms, and the flying distance between villages is about 10 minutes. Every time you fly to a village, you need people from the village to help replace the new battery, and then you can fly to the next village. The whole journey is a "relay" process.

　　"The plane must be fully charged before it can take off. The last time we saw the power of the plane was 82%, we felt that we could complete a flight, but after the start, the plane still could not take off. This may be the design made by the aircraft research and development enterprise for the absolute safety of the aircraft." Chen Zhongxiang said.

　　Temporarily unable to replace manual delivery.

　　According to the staff of the UAV R&D company, when the plane lands, it needs to lay a red and blue positioning carpet at the landing site. The UAV is equipped with a sensor in the vertical direction. When it searches for the positioning carpet, it will land accurately. Location.

　　Chen Zhongxiang told the reporter of Beiqing Daily that it was not the decision of the town post office to equip the town post office with drones, but the higher authorities chose the Weicheng post office as a pilot. If the use effect is good in the future, it will continue to be promoted.

　　"Many people in the village felt particularly fresh when they saw the plane at first, and the people in charge of managing the plane in each village also had a WeChat group. When the plane took off and landed, everyone would inform each other."

　　Annabelle of Xingguang Village Committee is one of the managers of this drone. Every time he receives the mail from his village, he also needs to replace the plane with a new battery. "If the battery is not fully charged, the plane can’t fly, but there will definitely be no forgetting to charge the battery. Everyone will remind each other when they have WeChat groups."

　　Chen Zhongxiang said that in the past, the postman of the post office had to go into the mountain three times a week, but now it has been reduced to twice a week, while the drone now flies twice a week. If the effect is good in the future, it will increase the flight frequency. "But due to the limitation of load, drones can’t completely replace the postman now, and everywhere they go, they need people to get express delivery for batteries. There are still some troubles. It would be nice if these jobs can be replaced by machines in the future."

　　Text/reporter Fu Wei