In the car home Haikou preferential promotion channel, we can see a high-profile car model-a preferential activity is under way. The starting price of this model in Haikou area is 390,900 yuan, and the highest discount is 135,000 yuan. If you are interested in this model, you can click "Check the car price" in the quotation form to get a higher discount.

The design of Volvo XC60 new energy is unique, and the front face design is fashionable. The car adopts a unique air intake grille design, which makes its overall style more refined. The body lines are smooth and full of strength. As a new energy vehicle, Volvo XC60 New Energy also has a unique logo and detailed design to show its environmental protection characteristics. The overall style is simple and generous, showing Volvo’s consistent high quality and elegant temperament.

Volvo XC60 new energy vehicle is a medium-sized SUV with a body length of 4708mm, a body width of 1902mm, a body height of 1656mm and a wheelbase of 2865 mm.. The car uses 255/45 R20 front and rear tires, with fashionable rim style and high visual impact. The body lines are smooth and exquisite, especially the design of the side lines is unique, which shows the perfect combination of luxury and sportiness. The front wheel track is 1649mm and the rear wheel track is 1653mm, which makes the vehicle more stable and better in handling.

The interior design of Volvo XC60 New Energy is simple and elegant, with attention to detail and texture. The steering wheel is made of leather, which can be manually adjusted up and down and back and forth, so that drivers can easily find the driving posture that suits them best. The central control screen has a size of 9 inches, supports voice recognition control system, and can control functions such as multimedia, navigation, telephone and air conditioning. The front and rear rows are equipped with USB/Type-C interface, which is convenient for users to charge. The front seats are also equipped with heating function, and both the driver’s seat and the co-pilot seat support power seat memory. In addition, the seat can be adjusted in front and back, backrest, height, leg rest and lumbar support to provide a comfortable riding experience. The rear seats support proportional reclining, and the space can be flexibly adjusted as needed.

Santana is a classic car with reliable quality and excellent performance. It has a maximum power of 228 kW and a maximum torque of 400 N m. It is equipped with a 2.0T 310 HP L4 engine, which provides a strong power output. At the same time, it is equipped with an 8-speed automatic gearbox, which can shift gears smoothly and quickly, making driving more comfortable. Whether on urban roads or highways, Volvo XC60 new energy can bring excellent driving experience.

As a luxury SUV, Volvo XC60 New Energy not only shows a unique design style in the appearance of the whole vehicle, but also performs well in the interior, performance and safety. Car home car owners’ evaluation of it is also very pertinent. He mentioned that although the removal of the tail throat made the back look a little bald, it was still acceptable. In addition, 24 wheels have been changed into low wind resistance shapes. Although some people don’t like them, they also have a sense of science and technology, which complements the overall style. It can be seen that the details and overall style of Volvo XC60 new energy have been recognized and affirmed by the owners. Whether on urban roads or highways, this model can provide excellent driving experience and safety guarantee. Therefore, for those consumers who pursue luxury, comfort and safety, Volvo XC60 new energy is undoubtedly a worthy choice.

Zhangjiakou car home preferential promotion channel brings you the latest preferential information! At present, the model is undergoing preferential activities, and the preferential amount is as high as 12,000 yuan. The activity covers Zhangjiakou area, and the minimum starting price is 140,900 yuan. If you are interested in this model, please click "Check Car Price" in the quotation form to get more preferential information. Act quickly, seize the opportunity and enjoy the car discount!

Tiggo 9 is a stylish SUV model, with a large air intake grille on the front face and streamlined chrome decoration, creating a strong visual impact. The body lines are smooth, and the overall style is tough and exquisite, showing a strong sense of movement. The lines on the side of the car body are simple and smooth, and the lines on the roof are tilted backwards, creating a dynamic shape. The tail design of the car body is simple and generous, and the taillights adopt a unique through design, which has excellent visual effects. In addition, the Tiggo 9 is also equipped with large-size wheels and sporty wheels to make the whole car look more sporty and fashionable. Overall, the design of Tiggo 9 is fashionable, dynamic and exquisite, and it is a very attractive SUV model.

As a medium-sized SUV, the Tiggo 9 has a length, width and height of 4820*1930*1699mm, a wheelbase of 2820mm, a front track of 1638mm and a rear track of 1641mm, respectively. The side lines of Tiggo 9 are smooth and dynamic, which highlights its sporty atmosphere. The front and rear tyre size are both 245/50 R20, and the tire width is larger, which provides better grip and stability for the vehicle. The rim style is fashionable and matched with the body lines, which makes the appearance of the whole vehicle more fashionable and atmospheric.

The interior design of Tiggo 9 is simple and atmospheric, with black and brown color matching, creating a high-end comfortable atmosphere. The steering wheel is made of genuine leather and feels comfortable. It supports manual adjustment up and down and back and forth, so that drivers can find the most comfortable driving posture. The size of the central control screen reaches 12.3 inches, and the display effect is clear. It supports the voice recognition control system and can control the functions of multimedia system, navigation, telephone, air conditioner and skylight, making it more convenient for drivers to drive. The front and rear rows are equipped with USB and Type-C interfaces for easy charging. The front seats also have heating, ventilation and electric seat memory functions, so drivers can enjoy a more comfortable driving experience. In addition, the second row of seats supports backrest adjustment, and the rear seats can be laid down in proportion, providing passengers with more space and flexibility.

The Tiggo 9 is equipped with a 2.0T 261 horsepower L4 engine with a maximum power of 192 kW and a maximum torque of 400 N m.. This engine can provide abundant power output, so that you can feel a strong sense of acceleration and surging power during driving. At the same time, with the 8-speed automatic manual transmission, the shift is smooth and fast, making driving more comfortable and smooth. No matter on urban roads or highways, Tiggo 9 can easily meet all kinds of driving needs and bring you excellent driving experience.

As a medium-sized SUV, Tiggo 9 has undoubtedly won the favor of the majority of car owners in terms of design. The owner of car home said that the design of Tiggo 9 gives people a very atmospheric and calm feeling, which is neither radical nor unassuming, and it is his favorite design style. This not only reflects the stability and atmosphere of Tiggo 9, but also shows its unique taste and style. It is believed that this design style can meet the needs of more car owners for vehicle appearance and bring more comfortable and confident driving experience to car owners.

　　Source: southern window.

　　"There is a new Great Wall in the north and BYD in the south." At the new car launch in 2022, Li Ruifeng, CGO of the Great Wall, still described the relationship between his family and his friends and businessmen as "North Qiao Feng, South Murong", just like appreciate each other between heroes.

　　But it didn’t arrive in a year, and North Qiao Feng gave South Murong a sneak attack.

　　On the morning of May 25th, Great Wall Motor issued a statement saying that it had submitted materials to the Ministry of Ecology and Environment, the State Administration of Markets, and the Ministry of Industry and Information Technology, and reported that BYD Qin PLUS DM-i and Song PLUS DM-i used atmospheric fuel tanks, which were suspected of failing to meet the emission standards of evaporative pollutants from the whole vehicle.

　　A few hours later, BYD made a statement saying that it resolutely opposed any form of unfair competition and reserved the right to legal proceedings. BYD said that the test vehicle submitted by Great Wall did not meet the requirements of the national standard, and that its test report was invalid.

　　One is the abdicated crown, and the other is the popular new king. The Great Wall’s tip-off letter to BYD, like a hero’s post widely distributed all over the world, made the auto market, which was already in dispute with blood and rain, stir up waves again.

　　Report what?

　　If you want to understand this matter deeply, you need to first interpret the core of the Great Wall report letter, that is, the problem that "the atmospheric oil tank is suspected of causing the evaporation pollutant discharge to fail to meet the standard".

　　Generally speaking, ordinary cars can use an atmospheric fuel tank. The fuel in the atmospheric fuel tank is controlled by atmospheric pressure and can be delivered to the engine by gravity or fuel pump.

　　This kind of oil tank is generally made of plastic and designed to work at atmospheric pressure. The internal and external environment are kept at the same pressure, and the positive pressure is 4~7Kpa.

　　However, for some hybrid vehicles, high-pressure fuel tanks are needed for the sake of emission standards.

　　Because compared with fuel vehicles, the engine of hybrid vehicles is not used frequently, and gasoline is very volatile. If it is not used often, it will accumulate a lot of oil and gas over time and easily escape.

　　Don’t underestimate these vaporized gasoline. The data show that fuel evaporation emissions account for about 20% of light vehicle emissions, which is one of the important sources of air pollution. The "National Six" emission standard has strict requirements on the fuel evaporation control system of automobiles, which makes hybrid vehicles need to solve this problem.

　　As a result, the high-pressure fuel tank came into being. In the high-pressure fuel tank which can bear pressure of 35~40Kpa, oil and gas will remain in the fuel tank under high pressure, and will enter the manifold through the carbon canister when the engine is running, thus reducing the emission of fuel evaporation.

　　BYD Qin PLUS DM-i and Song PLUS DM-i belong to hybrid vehicles. Facing the emission demand, high-pressure fuel tanks may be needed to prevent oil and gas from escaping.

　　After explaining the reporting point, let’s see if it is possible for BYD to use the atmospheric fuel tank.

　　According to common sense, Great Wall Motor obviously has some evidence in its hands when it reports with such fanfare. In BYD’s response, it did not deny the use of atmospheric fuel tanks, explaining that the mileage of the test vehicles that focused on the Great Wall was insufficient, and it was the point that the test report was invalid.

　　Due to the requirements of high-pressure fuel tanks for pressure resistance, the materials of such fuel tanks are mostly steel fuel tanks or encrypted plastics, and the matching fuel cap, fuel filling pipeline and evaporation pipeline also need to be specially made, and the cost is higher than that of atmospheric fuel tanks.

　　From the point of cost reduction, BYD does have the motivation to use atmospheric fuel tanks.

　　However, the hybrid vehicle using atmospheric fuel tank does not necessarily fail to meet the standard of fuel evaporative emission, which needs further testing and verification by relevant departments.

　　The reason why BYD played "3,000 kilometers" actually has a saying.

　　Qin PLUS DM-i and Song PLUS DM-i, as plug-in hybrid cars, have versions with a battery life of more than 100 kilometers. If you only run the "450-670 km" in BYD’s response, there is a high probability that a box of oil has not been run.

　　If a tank of oil is not run out, the frequency of natural internal combustion engine is not high. If it is left standing for a period of time and not kept and sent for inspection within the specified time, the test results may be biased and cannot objectively reflect the emission values of vehicles.

　　Therefore, just looking at the first round of confrontation, the Great Wall only hammered BYD’s "atmospheric fuel tank", but it was temporarily unable to hammer BYD’s emissions.

　　Why today?

　　There is an interesting detail in the tip-off. Great Wall reported BYD on April 11th, one and a half months earlier than May 25th.

　　Why is it so late? Is it because the two sides have communicated beforehand? Or did the Great Wall ever think about keeping a low profile?

　　Perhaps none of the above reasons, but more likely because BYD’s new car Song Pro DM-i Champion Edition is scheduled to be released on the afternoon of May 25th.

　　On the day when the car was replaced, it was "disgusting" to have friends and businessmen, and the "sneak attack" of the Great Wall was well prepared.

　　Hammer you, although it didn’t reach the so-called "filing" in the report letter, the invisible damage caused is really real. It will change consumers’ minds invisibly-that is, BYD’s products are controversial and may have the behavior of "cutting corners".

　　Even if these things are proved to be untrue in the end, this cognitive change has caused a negative impression.

　　It doesn’t matter if you have any questions. But it’s important for consumers to feel "you have a problem".

　　The so-called business war is to attack the minds of consumers.

　　Of course, BYD’s response is also very interesting.

　　The whole response, eight paragraphs, seven exclamation points, an average of nearly one paragraph. The last three paragraphs, or even a single sentence into paragraphs, each sentence has an exclamation point. Anger and grievances are almost overflowing.

　　The last sentence is even more straightforward. "I hope everyone will do more things that are beneficial to the industry and the China brand!"

　　The implication is that what Great Wall has done is harmful to both the industry and the China brand.

　　Since you attacked first, don’t blame me for being rude.

　　In the past, the hero cherished the hero’s "North-South Double Heroes", thus breaking away. This situation reminds people of the kind advice of a 69-year-old veteran comrade-Wulin should value peace, emphasize martial arts and not engage in infighting.

　　Frankly speaking, last year’s metaphor of the Great Wall actually raised its own worth and secretly degraded BYD.

　　Today’s China auto market is no longer the era when Haval H6 dominated the world. Although the Great Wall is still in the first echelon of auto companies, it is far behind by BYD.

　　In 2022, BYD sold 1,863,500 new cars, with an operating income of 424.061 billion yuan, a year-on-year increase of 96.2%. The net profit attributable to shareholders of listed companies was 16.622 billion, up 445.86% year-on-year.

　　In contrast, the Great Wall sold only 1,061,700 new cars last year, with a total operating income of 137.34 billion yuan, a slight increase of 0.69% year-on-year; The net profit attributable to shareholders of listed companies was 8.266 billion yuan, a year-on-year increase of 22.90%.

　　For BYD, 2022 is undoubtedly a bumper year. It has become the champion of its own brand, the champion of global new energy vehicles, and the champion of China automobile market, and it has won many "firsts".

　　The Great Wall is still in a difficult transition in the switch between the old and new markets. The sales target of "1.9 million vehicles" set in 2022 was less than 60%. The sales of Haval, Wei Pai, Euler and pickup trucks under its control fell across the board, while the sales of new energy vehicles declined from 139,000 to 132,000 compared with the previous year.

　　If you don’t want to describe them as Qiao Feng and Mu Rongfu, you have to change your position, and you have lost Mu Rongfu after Wang Yuyan.

　　What I did was big brother

　　Many people believe that BYD’s rise is based on new energy sources.

　　This sentence is correct, but it is not detailed enough.

　　Pure trams are new energy, and hybrid cars are also new energy. The most important thing about BYD’s strong rise in the past two years is that plug-in hybrid vehicles have gained wide market recognition.

　　In 2021, BYD successively launched three models: Qin PLUS DM-i, Song PLUS DM-i and Tang DM-i, which achieved the coverage of the mainstream price range of 100,000-200,000.

　　As a result, in the second year, sales broke out. BYD sold 946,200 hybrid cars, accounting for 50.94% of the total sales. The sales volume of BYD Song PLUS DM-i alone was as high as 380,000.

　　The same thing happened in the whole China market. In 2022, the sales growth rate of plug-in hybrid vehicles reached 150% year-on-year, and the growth rate of ultra-pure electric vehicles was 82%.

　　Plug-in hybrid cars with green license, exemption from purchase tax, subsidy and electricity saving are the "wealth code" of China auto market.

　　Great Wall Motor certainly saw through this. Although it started later than BYD, it soon joined the research and development of hybrid technology. In 2018, Great Wall Motor developed a new hybrid platform, which is now the lemon hybrid DHT system.

　　However, consumers who know that "the Great Wall is also very mixed" are far from knowing that "BYD is very mixed". The reason is that the "coffee series" of the Great Wall really sells badly.

　　On the one hand, the positioning of Macchiato DHT is slightly higher than that of Song PLUS DM-i, and the entry version is 20,000 yuan higher; On the other hand, the naming of "Macchiato" is controversial, which leads to its poor market recognition. In the end, due to the small sales volume, consumers can’t perceive the hybrid technology of the Great Wall, which makes the Great Wall lose its first-Mover advantage.

　　If this technology had been devolved to Haval H6 earlier, it is likely that the current SUV hybrid market is by no means a monopoly of Song Plus DM-I.

　　The former Haval H6, which has won the championship for 100 consecutive months, is a well-deserved "magic car" in China. Until January of 2022, Haval H6 was still the dominant player in SUV field.

　　Unfortunately, it was not until mid-August of 2022 that the mixed version of Haval H6 came late. At this time, the sales volume of H6 has fallen to the fifth place, and not only Song PLUS has surpassed it, but also Yuan PLUS has surpassed it.

　　The failure to grasp the mixed outlet is an important reason why the Great Wall is now trapped in transformation and its sales volume has fallen sharply. I want to make the brand high-end and new energy at the same time, and finally the Great Wall of "one fish and two meals" failed to do both things well. Looking back, this is undoubtedly a strategic mistake of the Great Wall.

　　Although there are many consumers who sing the Great Wall, from the market value point of view, Great Wall Motor with a volume of 210 billion+is still the "second brother" after BYD.

　　This time, the "second brother" challenged the "big brother". Although it is somewhat embarrassing, it is also the norm in business competition.

　　Aboveboard peer supervision also protects the interests of consumers to some extent. If there is unfair competition, I believe that the relevant institutions will eventually give the enterprise an innocence and give a statement after verification.

　　

Fast technology January 19 news, a few days ago, Xiaomi CEO Lei Jun released a video, personally taking everyone to immerse themselves in Xiaomi’s first car Xiaomi SU7.

As you can see,Lei Jun unlocked the vehicle through Xiaomi Watch, and at the same time, the tail wing also rose synchronously, which was very handsome.

After Lei Jun enters Xiaomi SU7 and starts, the main driver’s seat will be automatically adjusted to the memory position. The advantage of this function is that it is convenient to get on and off.

Xiaomi SU7 is also equipped with a dashboard that supports automatic flipping.Support to display total mileage, gear, driving mode and total energy consumption.

Finally, Lei Jun also demonstrated the head-up display function in the car, which can display information such as remaining power, speed and navigation.

The watch is unlocked, the tail wing is automatically raised, the main driver is automatically adjusted, and the dashboard is automatically turned over. It must be said that these processes in one go have already filled the sense of ceremony before Xiaomi SU7 runs.

It is worth mentioning that some netizens sincerely asked Lei Jun in the comment area: Will there be Redmi cars? ".

In this regard, Lei Jun replied: At present, we are still focusing on Xiaomi Automobile. "

It is understood that the first models of Xiaomi SU7 will be equipped with Xiaomi super motors V6 and V6s, with a speed of up to 21,000 rpm, and adopt a new super 800V silicon carbide high-voltage platform developed by Xiaomi, with a maximum voltage of up to 871V V.

(reporting)

　 　 　 　Luo Jing, the host of the famous News Network, Cindy Lee, the actor who plays Fang Yu in Deep Rain, and Fuck off! Tumor jun touched many netizens’ cartoonist Xiong Dun … In recent years, many celebrities have passed away because of lymphoma. At the same time, however, there are also many famous people who have succeeded in fighting cancer after suffering from lymphoma. For example, the 70-year-old famous director Wu Yusen was diagnosed with large B-cell lymphoma in tonsils when filming Taiping Wheel in 2008. After four operations, in the second month of chemotherapy, his mouth was all festered, he could not swallow, and his body and face were so thin that he was wrinkled. Finally, he succeeded in fighting cancer with his firm will! 　

　 　 　 　For example, Kai-Fu Lee, the founder of an innovative factory that successfully used chemotherapy and targeted therapy to fight advanced lymphoma! On September 5, 2013, 52-year-old Kai-fu Lee announced that he had stage IV follicular lymphoma and had to leave work for treatment. In February 2015, he announced the results of his physical examination, indicating that the tumor in the body is not obvious at present. In June of the same year, Kai-fu Lee said that he had not found any lesions in his last two examinations and ridiculed himself as "Li Kangfu". It took Kai-fu Lee less than two years from finding out the cancer until the focus was completely gone. His anti-cancer experience is worth learning from.

Alias "the most disguised disease", lymphoma has become a killer.

　 　 　 　According to statistics, there is a new case of lymphoma every 9 minutes in the world. The incidence of lymphoma in China is 0.02‰, with about 25,000 new patients and nearly 20,000 deaths each year. The threat of lymphoma is rapidly emerging. It ranks among the top ten malignant tumors in China and ranks second among hematological malignancies. At the beginning, the symptoms of the disease were hidden, and it was described as "the most disguised disease". In the intercontinental area, the incidence of non-Hodgkin’s lymphoma is much higher than Hodgkin’s disease, which is about 9: 1. Because of the higher degree of malignancy and worse prognosis, lymphoma is generally referred to as non-Hodgkin’s lymphoma. In China, the incidence of malignant tumors ranks ninth among men and tenth among women. Non-Hodgkin’s lymphoma can occur in all ages, and the high incidence age is 45~60 years old. Among them, Luo Jing suffered from diffuse large B-cell lymphoma (DLBCL). This is a common non-Hodgkin’s lymphoma, which belongs to aggressive lymphoma with high malignancy. The course of the disease progresses rapidly. If it is not actively treated, the median survival time is less than one year. In recent years, great progress has been made in the research and treatment of lymphoma, and new drugs and technologies have risen strongly! CAR-T therapy Among them, the chimeric antigen receptor T(CAR-T) cell therapy is particularly prominent. Its appearance represents a great progress in personalized cancer treatment, especially bringing the hope of rebirth to patients with hematological malignancies.

Complete remission! The first advanced lymphoma patient in China who received CAR-T therapy was discharged smoothly!

　 　 　 　Although they all suffer from diffuse large B-cell lymphoma, Mr. Chen, who suffers from malignant lymphoma, is a lucky one. According to Jiangsu public news channel News Space Station, on August 31st, the first lymphoma patient treated with CAR-T cells in China achieved complete remission and was discharged smoothly. 　

　 　 　 　Mr. Chen suffered from diffuse large B-cell lymphoma. After the onset of the disease in October 2010, he had received chemotherapy for many times, but all of them were unsatisfactory. Diffuse large B-cell lymphoma is the most common malignant lymphoma. After immunotherapy, about 60% patients can survive for a long time, but 40% patients will still relapse. In June this year, Mr. Chen accepted CAR-T cell therapy with a tentative attitude, and all the physical indicators tended to be normal. He told reporters with delight that his physical condition was better than before, and he was no different from a normal person after leaving the hospital. CAR-T therapy, a "living drug", made her completely relieved and looked forward to a cancer-free future.　

　 　 　 　As a "living" drug, CAR-T therapy is very different from traditional drugs. First, the therapy needs to isolate T cells from patients and modify them with chimeric antigen receptor (CAR) in vitro, so that they can specifically recognize cancer cells. Finally, the modified T cells are expanded and reinfused into patients. Compared with traditional chemotherapy and hematopoietic stem cell transplantation, it can kill tumor cells more accurately, improve the curative effect and greatly reduce the side effects. 　

The well-known director of hematology in China said: CAR-T can identify lymphoma very deliberately, and the antigen carried on tumor cells will attack directly after being connected, and it will produce an anti-tumor effect and kill it directly without the need for second signal stimulation, so one of its characteristics is accuracy, and the second is power. The scope of application is still the recurrence or refractory diffuse large B lymphoma that is ineffective in general immunochemotherapy. 　

CAR-T therapy FDA approved 6 models, and domestic CAR-T therapy caught up! 　　　

　 　 　 　After sharing the above news reports about CAR-T therapy, let’s get down to business and talk about CAR-T therapy. At present,CAR-T therapy has achieved great success in the treatment of hematological malignancies.. Six CAR-T cell therapies have been approved by FDA in the United States and two CAR-T cell therapies have been listed in China. The picture below shows CAR-T cell therapy that has been listed at home and abroad. 　 　　

　 　 　 　Although China’s CAR-T technology started late, the domestic market is large. According to the data on Clinicaltrials.gov’s website, China became the country that registered the most CAR-T tests in September 2017. As of May 27th, 2021, there are 1301 CAR-T clinical trials in the world, and the number of CAR-T trials registered in China has reached 478!　

01　　The first CAR-T therapy in China was approved for listing! China welcomes the first year of cellular immunotherapy.

　 　 　 　On June 22nd, the blank in the field of CAR-T in China was finally broken! The latest announcement of China National Medical Products Administration (NMPA), Fosun Kaite Biotechnology Co., Ltd. (hereinafter referred to as " Fosun Kate ”） The CAR-T cell therapy product targeting CD19, Aquilencel Injection (also known as Aquilencel, FKC876), was officially approved for marketing. This is the first approved CAR-T therapy in China and the sixth approved CAR-T therapy in the world. It is believed that China will usher in the blowout era of CAR-T cell therapy.　

02　　In just one month, the second CAR-T therapy in China and the sixth CAR-T therapy in the world were approved!

　 　 　 　On September 3, the State Drug Administration recently announced that Yaoming JunuoThe CAR-T product targeting CD19, Regiosai Injection.(relma-cel, trade name: Benoda) has been officially approved. The approved indications for Regioside Injection are:It can be used to treat relapsed or refractory large B-cell lymphoma (r/r LBCL) in adult patients after second-line or above systemic treatment.Reggiorense injection is the second CAR-T product approved in China and the first CAR-T product of Class 1 biological products in China.

　

It’s only been about one month since it was submitted for examination and approval on July 30th last time, which can be described as rapid progress. Congratulations! (At present, patients with economic conditions can contact cancer-free homes for the treatment of regiorense. )　

Boom! The first BCMA CAR-T therapy in China and the second in the world was approved by FDA!

　 　 　 　China’s "dark horse" in CAR-T cell therapy industry-legendary BCMA(B-cell mature antigen) CAR-T therapy Cedar-B38m/JNJ-4528 (hereinafter referred to as cilta-cel) has attracted much attention, and has shown excellent anticancer activity in clinical trials for multiple myeloma.

　 　 　 　What is exciting is that on February 28th, 2022, local time, it was jointly developed by Janssen and Legendary Biology.BCMA CAR-T product, Cedactylosin (trade name Carvykti), has been approved by the US FDA for the treatment of adult patients with relapsed/refractory multiple myeloma (MM).

This is the first cell therapy product approved by FDA in China and the second CAR-T cell immunotherapy approved for BCMA in the world.

　

　 　 　 　Cilta-cel was awarded priority review qualification by FDA on May 26th.However, the approval of the West Dachiorensai was delayed, and it was adjusted from November 29, 2021 toFebruary 28, 2022Fortunately, it was finally approved and lived up to expectations!

　 　 　 　cilta-celIt is a CAR-T therapy directed by research B cell maturation antigen (BCMA), which is used to treat relapsed or refractory multiple myeloma (RRMM). These patients received an average of five kinds of pre-treatment before treatment, 76% of them received five kinds of treatment, and 86% of them were resistant to five kinds of treatment, including CD38 treatment, and they were both resistant to protease inhibitor PI and immunomodulator IMiD. Simply put, it is refractory to relapse and lack of effective treatment in the follow-up. The principle of this CAR-T therapy is different from the current PD-1/L1. It directly uses the T cells in the patient’s body, transforms them in vitro, replicates them in large quantities, and then transfuses them into the patient’s body to kill cancer cells. At the ASH conference in 2021, the latest results of the 1b/2 CARTITUDE-1 study (n=97) showed that,meso-position 22 months Long-term follow-up, The objective remission rate (ORR) reached 98% , 83% patients achieved strict complete remission (sCR) It is emphasized that the mitigation will deepen with the passage of time (sCR will increase from 67% reported at the ASH annual meeting in 2020 to 83%). At 18 months, 66% of the patients were alive and the disease did not progress. .The two-year progression-free survival rate and overall survival rate are respectively 61% and 74% .The latest research results to be announced at the ASCO annual meeting in 2021 show that After a median follow-up of 18 months, the overall survival (OS) rate was 81%. The remission rate is comparable in all pre-specified subgroups and patients with different treatment lines.

　　 　

American research shows that cilta-cel has excellent long-term efficacy.　 　

　 　 　 　Emily, a foreign country, successfully ushered in nine years of cancer-free survival in 2021, and suddenly became the "spokesperson" of global CAR-T therapy. In China, there is such a lucky person whose fate has been completely changed by CAR-T therapy. Mr. Min was diagnosed with a special rare disease at the age of 54- multiple myeloma . He had no drugs available at that time, so he was lucky enough to participate in the clinical trial of CAR-T therapy. Although the treatment process was not smooth sailing, after three times of treatment, all the lumps on Mr. Min’s body disappeared and the pain disappeared. Surprisingly, by June 4, 2021, Mr. Min had lived cancer-free for five years, which is the field of cancer treatment, which is theoretically said. Clinical cure .

　 　 　 　In fact, as early as March 27th this year,The FDA approved the first CAR-T therapy targeting BCMA for adult patients with relapsed/refractory multiple myeloma (r/r MM) after receiving more than four therapies.

　 　 　 　Chemotherapy to fight cancer is often "killing one thousand enemies and losing eight hundred". Antibody drugs can accurately find tumor targets, but sometimes their combat effectiveness is insufficient. If we can put a "warhead" of chemotherapy drugs on antibody drugs, can we attack cancer cells more accurately? Based on this, an ADC (antibody drug conjugate) called "biological missile" was born. Antibody-coupled drugs are like biological missiles, which consist of two core functions: the first is antibody (missile body), the second is strong chemotherapy drug (nuclear warhead); This design will enable antibodies to find tumor cells with chemotherapy drugs, and then accurately poison tumor cells and poison them. 　This drug design combines the precision of targeted drugs with the high efficiency of chemotherapy drugs, which not only avoids the toxic and side effects of systemic use of chemotherapy drugs, but also has stronger killing ability than using targeted drugs alone, killing two birds with one stone. 　 　 　 　

Schematic diagram of antibody-coupled drugs 　 Note: (a) General description of A)ADC structure; (b) the mechanism of B)ADC. 　

Fourteen ADC drugs have been approved around the world, which brings hope for prolonging the survival time of back-line patients.

　 　 　 　At present, more than 100 kinds of ADC are undergoing clinical trials. Most adcs have progressed from phase i to phase II. Some ADC phase III trials show positive results; Up to September 20th, 2021, there are 14 kinds of ADC drugs on the market in the world, which are mainly used in hematological tumors and solid tumors, and are mainly used for back-line treatment of patients, including advanced, recurrent/refractory and metastatic tumor indications.

　

Fourteen ADC drugs have been approved worldwide.

According to the curative effect data, ADC drugs have brought more treatment options and the hope of prolonging the survival time for back-line patients, and the objective remission rate or median progression-free survival time of several drugs has doubled compared with chemotherapy.

Looking at the CD30 target, the new drug F0002-ADC became an instant hit and squeezed into the lymphoma track.

　 　 　 　CD30, a member of tumor necrosis factor (TNF) receptor superfamily, can promote cell proliferation or apoptosis by activating different signal pathways. In 2020, Vebtuximab for injection (Adcetris) was approved to be listed in China, and CD30 became famous. Adcetris, as an antibody-coupled drug targeting CD30, has an effective rate of 73% for Hodgkin’s lymphoma (HL) and 86% for anaplastic large cell lymphoma (ALCL). It is the first new drug approved in the field of Hodgkin’s lymphoma treatment in recent 30 years, and it is also the first time that a drug targeting CD30 has been approved, filling the gap in this field. At present, the only new ADC drug for CD30 in China is F0002-ADC. This new drug consists of three parts, namely, human-mouse chimeric anti-CD30 monoclonal antibody, thioether linker (MCC) and DM1. Since the project was launched in 2016, it has been disappointing! At present, patients with recurrent/refractory CD30 positive peripheral T-cell lymphoma are being recruited clinically! This is a new treatment option for patients with recurrent/refractory peripheral T-cell lymphoma!

This article is original for a cancer-free home, and it needs authorization to reprint! Cancer-free homes remind patients 　

Mercedes-Benz E-Class is a traditional luxury medium-sized and large-sized car product. For Biao and Audi a6l, its unique brand advantages and extreme luxury attributes have made it deeply recognized by consumers, with an average monthly sales volume of more than 13,000, which is in a strong competitive position in this market segment.

Mercedes-Benz e300l luxury design atmosphere, strong business atmosphere, the front shield-shaped mesh is quite eye-catching, two bar-type led light groups are shiny and recognizable, and the erected three-pointed star logo is also noble and elegant, which can always give people a strong psychological hint. The side is slender and smooth, the lines are smooth and sexy, the rear tail is sexy and stocky, the bilateral double exhaust is quite graded, and the overall face value is remarkable, which is a small S-class.

In terms of power, e300l is equipped with a 2.0t high-powered version, 190 kW, 370 Nm, equipped with a 9-speed manual, with a zero-hundred-speed score of about 6.6 seconds, which makes the acceleration feel smooth and calm at the beginning, and at the same time, the latter part is full of confidence and orderly shift logic, which is always indifferent and comfortable to drive, and can raise the speed to a very high level unconsciously.

In terms of structure, the training style is still very comfortable, the bumps on the road are handled in place, and there is not much impact when taking some bad roads. Driving is particularly heavy and advanced, which will definitely bring people the highest level of enjoyment, which is in line with the level that this level should have.

In terms of selling price, the official guide price of the 2019 Mercedes-Benz e300l Deluxe Edition is 492,800, with a preferential margin of about 40,000. The transaction price of the bare car at the terminal is 452,800, including 40080 purchase tax, 480 travel tax, 950 compulsory insurance, 12,299 commercial insurance and 500 licensed cars, totaling about 507,200.

Car experience:

Most satisfied with fashion and youth, cool atmosphere lights and a sense of science and technology in off the charts! 9-speed automatic transmission, almost no frustration!

The most dissatisfied with the sound effect is just so-so. The original car’s own sound is really lame, not as loud as Berlin’s.

[Space] The space in the front row of my 176 is quite large. There is not much horizontal space for two people. Three people are not very comfortable. From driving to now, I have only gone home for the Spring Festival, and I have been full of company group tours. Basically, I am alone.

[Power] The power is smooth between 234 gears, and occasionally, there will be some setbacks in oil collection.

[Control] Control is general, and this owner plays.

[Comfort] The front seat is comfortable and the rear seat is short.

[Appearance] I bought a sports label with pearl white. I feel very young. In fact, I am already young.

[Interior] Family-style design is adopted, just like driving an S. Due to the hasty booking of a car, the car comes with a black interior, which is a little depressing, but quite resistant to dirt.

[Cost-effective] If people like me don’t pay attention to performance, people who look at their eyes will buy a car of around 500,000, which is still very good.

Provided by the author

On October 24th, after the incident of eyebrow pencil in 79 yuan, the live broadcast room in Li Jiaqi broadcasted Huaxizi with goods again after 43 days. However, Li Jiaqi himself did not appear to explain the product of Huaxizi, and the controversial ace product Huaxizi eyebrow pencil did not appear in the live broadcast list. According to Time Finance, Hua Xizi’s performance in the live broadcast room in Li Jiaqi is still good, but compared with last year, it is much worse.

I and the disputed eyebrow pencil did not appear.

In the list of products with goods in Li Jiaqi Live Studio, there are three products owned by Hua Xizi, namely, a combination suit of 357 yuan, a powder cake of 149 yuan and honey powder of 129 yuan. According to Time Finance, at 8 pm, the live broadcast room in Li Jiaqi exceeded 10 million people. After the countdown was displayed on the screen, the gongs and drums in Li Jiaqi’s hand were sounded, and the pre-sale of Tmall "double 11" officially kicked off this year.

As soon as the live broadcast was started, more than 7,000 pieces, 3,000 pieces and 300 groups of Huaxizi air honey powder, Yurong gauze powder cake and water hibiscus in the Li Jiaqi live broadcast room had been booked respectively. At 8: 02, more than 20,000 pieces, 9,000 pieces and 1,000 pieces of three groups of products were ordered respectively. The figures will change every few minutes. By 10: 30 pm, the pre-sales of the above three groups of products exceeded 70,000, 3,000 and 30,000 respectively. According to Red Net, as of 11: 30 p.m. on 24th, the amount of honey powder with a price of 129 yuan for Huaxizi has exceeded 80,000 orders, the amount of powder cake with a price of 149 yuan has exceeded 30,000 orders, and the combined set with a price of 357 yuan has exceeded 3,000 orders, totaling more than 110,000 orders.

Although Hua Xizi’s performance in the live broadcast room in Li Jiaqi is still good, compared with last year, it is much worse. According to previous media reports, at 9: 00 pm on October 24th, 2022, the colored powder cake of Huaxizi Yurongsha was first released in the live broadcast room in Li Jiaqi. After only 15 minutes on the shelves, 250,000 colored powder cakes were sold out. According to Time Finance’s analysis, in addition to the previous storm, the sales volume of Hua Xizi was affected, and this sales performance may be related to the fact that Hua Xizi did not appear in the prime time of the live broadcast room in Li Jiaqi this year. According to Red Net, as of 11: 30 pm on the 24th, the number of viewers in the live broadcast room in Li Jiaqi was still at 10 million+.

The controversial ace product Hua Xizi eyebrow pencil did not appear in the live broadcast list. According to Time Finance, in the live broadcast room of Huaxi’s official flagship store, the anchor said that the eyebrow pencil "double 11" activity had not been announced. In the live commentary area, some netizens said bluntly: "I will never buy it again, which is really sad" and "How dare he"; However, some netizens said: "Although I am not interested in Hua Xizi, I am still interested in the things in the live broadcast room in Li Jiaqi."

Hua Xizi deeply binds Li Jiaqi.

Earlier, on September 10th, when Li Jiaqi introduced a Huaxizi Eyebrow Pencil in 79 yuan, he saw a message from a netizen saying it was expensive, and replied that 79 yuan Eyebrow Pencil could not be bought because he didn’t work hard enough. At the same time, it was exposed that 79 yuan Eyebrow Pencil was only 0.08 grams more expensive than gold, which led the netizens to think that Li Jiaqi despised ordinary people, created anxiety and inflated commodity prices.

In the early morning of September 11th, Li Jiaqi posted a blog post apologizing, and released an apology video on the evening of the same day, saying that his inappropriate remarks disappointed everyone, and he would also reflect on why he started in the first place and how he could serve more girls. Thank you again for your criticism and supervision. However, many netizens said that they "don’t buy it" for Li Jiaqi’s apology, and joked "Where ‘ Li ’ Wrong? " According to Xinmin Evening News, before the eyebrow pencil incident in 79 yuan, the number of fans in Weibo, Li Jiaqi was 30.435 million. By 11: 00 on October 24th, the number of fans was 28.747 million, and the number of fans dropped by over 1.68 million.

According to the International Finance News, four years ago, Hua Xizi announced Li Jiaqi as the chief recommender of the brand. At that time, this little-known brand was established only two years ago. With the help of the flow of "lipstick brother", the sales of Huaxizi reached 1.13 billion yuan that year, which was 25 times higher than that of 2018. The deep binding between the two parties began in 2019. According to the magic mirror data, the sales of Huaxizi’s star product, carved lipstick, increased by 165% month-on-month after it was promoted by Li Jiaqi multi-platform in May of that year. On the battlefield of "double 11", Hua Xizi never missed the live studio in Li Jiaqi from the pre-sale stage, and with the help of Li Jiaqi’s strong ability to carry goods, he won 220 million yuan GMV for the first time in the war and became the second place in domestic beauty cosmetics.

Around the "double 11" in that year, the live broadcast room in Li Jiaqi contributed 64% of the total turnover of Huaxizi. In June, 2022, Li Jiaqi stopped broadcasting for some reason. During the "June 18th Promotion" period, the sales of Huaxizi, who lost Li Jiaqi, dropped to 150 million yuan from 263 million yuan in the previous year. According to shanghai securities news, the founder of Huaxizi once said in public that their cooperation with Li Jiaqi is Live Delivery 2.0, that is, inviting anchors to create products together. Some insiders revealed: "As long as this product Li Jiaqi says no, it will not pass."

After the eyebrow pencil dispute, Li Jiaqi gradually withdrew

Although Li Jiaqi still has a long way to go to quell doubts and rebuild trust, compared with Hua Xizi who was involved in the storm by his inappropriate remarks, as the starting point of the storm, he seems to have gradually withdrawn from the continuous controversy.

According to previous poster news reports, on September 26th, Li Jiaqi was carrying goods live on Taobao on the night when Hua Xizi’s crazy public relations sparked heated discussion. At the beginning of the storm, a large number of netizens flocked to the live broadcast room in Li Jiaqi to denounce it. Then, there were few questioning voices in the comment area, and the live broadcast room seemed to have returned to its former order. At 21: 42 on September 26th, the poster journalist entered the Taobao live room in Li Jiaqi, when he was carrying lipstick of Mao Geping brand, and the number of viewers in the live room was 7.146 million.

According to the International Finance News, the third season of the self-made variety "All Girls’ OFFER" produced by US ONE arrived as scheduled, showing the process of "negotiation" between Li Jiaqi and major beauty brands, which greatly promoted the upcoming "double 11". Janice (pseudonym), a well-known MCN organization engaged in beauty cosmetics vertical operation, said in an interview with the International Finance News that the Li Jiaqi incident had no impact on her MCN organization. "No matter what, the brand will still come to us for cooperation."

An insider of ONE told reporters that after the incident, the company’s publicity scale during the "double 11" period may be reduced, but "the traffic brought by the live broadcast room in Li Jiaqi is still very large." It is blunt that in the past few years, US ONE has established a large-scale system from product selection to after-sales improvement, and it still has advantages in the field of live e-commerce. "Especially after public relations, the trend of public opinion has become ‘ I don’t care about the anchor, anyway, as a consumer, it is good to buy a cheap and cost-effective product ’ 。” However, in the view of Wang Tian (pseudonym), a business practitioner of a live broadcast room in online celebrity, Tik Tok, if the live broadcast room in Li Jiaqi accounts for a large proportion of the brand’s performance planning of Taobao platform, after the storm, the brand may avoid risks by reducing the frequency of cooperation with Li Jiaqi and increasing the number of people to broadcast. "In the long run, the brand will expand other options besides super anchor. They also have their own plans and will not bet on one person. "

Upstream news is integrated from The Paper, Xinmin Evening News, International Finance News, Red Net, shanghai securities news, etc.

From Chen Kun to Roy and Karry, among the stars who are constantly "harvesting" attention in the entertainment circle, it seems that there is never a lack of Chongqing elements. If it is said that ten years ago, Chen Kun began to impress the audience with his youthful and immature acting skills, it was the beginning of Chongqing children’s journey in the entertainment circle; Then at the dawn of the second decade of the new century, successors have appeared on this long journey …

Needless to say, Roy and Karry, two children who have long been popular all over the country through TFBOYS, Sean Xiao, who won the popularity of the new generation of actors this year, Vin, Ivan and YoRoll , who are the most popular new men’s team at present, followed closely, and J.zen, Gu Landi and other names have repeatedly refreshed your understanding of the newcomers in the entertainment circle. In the next decade, it should be the following new forces that attract your attention and guide your remote control and mouse.

Sean Xiao

The hottest Chinese actor this year

How new is the "new power"? We might as well take the year 2000, the first year of the 21st century, as the base point.

That year, Chen Kun was a student of the Beijing Film Academy. After the movie "National Anthem", he participated in his second drama "Like Fog, Like Rain and Like Wind", but at this time he was just a little coffee hidden behind the highlights of Zhou Xun and Lu Yi. This year, Roy and Vin were born, Karry just turned one year old and YoRoll  and Ivan were two years old. The older ones are J.zen and Gu Landi, who are 5 and 6 years old respectively. Xiao Zhan, who is 9 years old, should start learning piano under the guidance of his father.

Wei Wuxian played by Sean Xiao The Untamed.

In a blink of an eye, 10 years later, they all became "popular fried chicken", and some of them were even hotter than Chen Kun in 2000.

If you want to ask how hot Sean Xiao is now? Just pay a little attention to the frequency of his name appearing in various news information in the last week, and you can perceive one or two. New Year’s Eve and New Year’s Day are approaching. He is on the guest lists of CCTV, Beijing Satellite TV and Oriental TV. Among them, Beijing Satellite TV also chose Sean Xiao as the spokesperson for the 2020 Spring Festival Gala.

Sean Xiao became the spokesperson for the 2020 Beijing Spring Festival Evening.

Not only that, all kinds of "harvest" hot search and attention in Sean Xiao can be described as full bloom. Let’s take a closer look at the variety field. In the music reality show "The Voice of Chinese Dreams Our Songs", which is being broadcasted by Oriental TV, his partner, Tian Na Ying, praised him as "really handsome" from the first sight, and the following two people’s cooperation, "Follow Your Feelings" and "Night at the Naval Port" were hotly debated in every capital.

Sean Xiao has become the "darling" of fashion magazines.

Secondly, magazine covers and photos, which have always been Vogue of the main battlefields for star competition, have ELLE published Sean Xiao’s photos or covers.

In the field of TV series, The Untamed, a costume drama that was popular all over the network in June this year, was regarded as the tipping point of Sean Xiao’s popularity. In the play, his handsome appearance is just in line with the audience’s imagination of Wei, the original character: clean, optimistic and cheerful. On December 20th, Douban made a ranking list from movies to TV series in 2019. The Untamed ranked third in the highest-rated Chinese drama series in 2019 with 8.3 points, and Sean Xiao won the first place among the most watched Chinese actors in 2019.

Sean Xiao in college.

Compared with several Chongqing babies who will be mentioned later in Ran Ran, Sean Xiao is not too young. Born in 1991, he studied painting, violin and other literary specialties under the cultivation of his father since childhood. In 2010, Sean Xiao was admitted to chongqing technology and business university Modern International Design and Art Institute. Since he entered the school, he has been a member of the class’s literary and art committee, and also served as the head of vocal music department and male voice department of the college students’ art troupe, as well as an actor of the school’s language and art sub-group.

In her sophomore year, Sean Xiao, who won the title of "Top Ten Singers on Campus" in chongqing technology and business university, participated in the "Top Ten Singers on Campus" competition in Chongqing on behalf of her school and won the second prize. It is worth mentioning that when he was a student, Sean Xiao also played a lot of tricks in his professional field: in 2012, he and his friend Camera founded the "Recalling Light and Shadow Visual Media" photography studio and the "NED Design Studio", and he was the main photographer and designer.

Until now, Weibo’s name in Sean Xiao still retains the head of his newly-debuted group "X-Nine Youth League". In June 2015, he was invited to participate in Zhejiang Satellite TV’s amateur inspirational program "Burn Boys" and became a trainee. In the finals in February of the following year, although Sean Xiao and his teammates narrowly lost to the Chris Lee team, in September of the same year, they announced their debut as the lead singer of the X-Nine Youth League. Since then, Sean Xiao’s performances in costume dramas "Breaking the Sky" and "Your Highness the Wolf" have been recognized by everyone. In the popular costume drama Joy of Life, although Sean Xiao is a supporting role, the hot discussion expected by netizens has spread all over the network since the first day of the drama.

Up to now, the number of Weibo fans in Sean Xiao has reached a staggering 21 million, and among the more than 700 Weibo posts, the likes of any one easily exceeded 1 million. It is no exaggeration to say that, as Douban commented, he is definitely the first most concerned Chinese actor at present.

The hottest new men’s team "R1SE"

Three of the 11 members are Chongqing children.

R1SE men’s team

On 14th of this month, R1SE, a men’s group, announced that it had been a group debut for less than half a year, put "WE ARE R.1.S.E-2019 R1SE National Tour Concert" into the Chongqing Concert of Chongqing Huaxi International Cultural and Sports Center. The scene is naturally screaming and cheering. This concert is of great significance to the three members of R1SE: Vin, Ivan and Zhang Yanquan are authentic Chongqing babies.

For this reason, R1SE specially designed an interactive session with unique regional characteristics for Chongqing fans. The members not only adapted the lyrics of the song "Deba" into Chongqing dialect "Yaode", but also performed a dialect chorus with the live fans. Combined with Chongqing special hot pot, a creative game "What’s in the hot pot restaurant" was created, which made the concert scene burst into laughter again and again.

Back in June this year, the reality show "Creation Camp 2019" launched by Tencent Video specially selected men’s teams finally scheduled the final seats. According to the program rules, 11 members of the "R1SE" group who made their debut as a group were born. Among the 11 members born after the elimination of 101 trainees, three Chongqing children were included: the names of Vin, Ivan and YoRoll  instantly became popular on the Internet.

Vin

You are not mistaken. After 00, you have already started to board this eye-catching stage. Vin, the third of the three, was born in 2000, while YoRoll  and Yao Chen were both born in 1998. According to Vin’s self-report when he participated in Creation Camp 2019, his idea of going on stage was influenced by Michael Jackson: in 2012, at the age of 12, after watching Michael Jackson’s performance in This is it, he had the idea of going on stage for the first time, and it got out of hand. He first signed up for a street dance class, and then spent two years persuading his parents to let him take the road of acting. Before participating in the domestic draft variety show, he went to an entertainment company in South Korea as a trainee in 2014.

Before this year’s "Creation Camp 2109" won the C place, Vin had already won the fourth place in the 2017 musical idol cultivation program "Son of Tomorrow" and made her debut. Two months ago, Vin was selected into the 2019 Forbes China list of 30 elites under the age of 30 by virtue of her popularity.

Ivan Yao

Ivan, born in 1998, also had the experience of joining a Korean entertainment company as an intern. In "Creation Camp 2019", Yao Chen’s first stage performance of "Baddd" attracted countless attention. During the performance, Ivan inadvertently lifted his T-shirt to reveal eight abdominal muscles, which also made him known as a "small waist" by fans.

YoRoll 

YoRoll  is famous for her "interesting soul" among R1SE members. On the one hand, he keeps making golden sentences in the "Creation Camp 2019" program, such as calling PK among students "mutual torture to the bald head"; On the other hand, the scene of Chongqing Xiaoer, who is super spicy, recommending Laoganma’s hot sauce for other students in the program has also made fans talk about it for a long time.

The scene of YoRoll ‘s crazy recommendation of hot sauce

As he himself said in the program, his interest in rap began in junior high school. "My classmates showed me a rough MV made by a domestic rapper, but the content was very close to life." He immediately fell in love with this form of writing everything that happened around him into a song and began to try originality. Nowadays, family members are very supportive of this road chosen by Zhang Yan. In an interview, he even laughed that his father is his number one male fan. "His ten circle of friends, nine of them are all about me, and I find people everywhere to like me."

J.zen

A cold folded ear root was forwarded by Weibo for more than 240,000 times.

On December 22nd, J.zen’s name was posted on the hot search because Ronghao Li, who had just finished his concert in Chongqing, met Xiao Zhu at the airport and stopped him. At first, he didn’t react. When he recognized that he was Ronghao Li, the music tutor when he participated in the online comprehensive Idol Trainee, J.zen’s appearance as a good student made fans happy instantly.

J.zen

If you don’t know J.zen, it only means that you are either old or Out.

Now logging in to Luneng Bashu Middle School, official website can find J.zen’s name in the classmate record of Class 16, Grade 2012.

J.zen was born in Chongqing in 1994. Until now, if you log in to Luneng Bashu Middle School, official website can find his name in the previous student lists. He is in Class 16, Grade 2012. Compared with Chongqing’s fellow villagers who are equally popular in the entertainment circle today, J.zen is a broader type. He and Variety should have been electrocuted since high school: in 2011, J.zen’s name was included in the second season of China’s Got Talent. Later, he entered Beijing Modern Music Institute to study in university.

The reason why J.zen dabbles in a lot is that he has appeared in the dance competition program, the magic reality show and the most popular variety show "Hip-hop in China" in 2017 (entering the top 46 in China). However, if we really want to say that J.zen’s name is on fire, it is inseparable from the reality show "Idol Trainee" formed by the idol men’s team that was red and purple last year. In this program, J.zen and the current traffic took the PK of KUN, Chen Linong and Adam, and finally ranked 14th. This achievement is quite rare.

This year’s Spring Festival, J.zen’s cold salad is broken.

How hot is J.zen, who has released his second personal music EP "Something Worth mentioning" in April this year? The reporter noticed that the number of his real-name authentication fans in Weibo has already exceeded 6.4 million. As a Chongqing cub, he is naturally unambiguous in eating. Apart from basking in the Vlog that he made "Chongqing tomato scrambled eggs" and "boiled meat slices", this year’s Spring Festival J.zen basked in a picture of himself eating New Year’s Eve dinner at home in Chongqing: "The legendary braised fish of grandma and the broken ears of grandpa’s cold salad". This Weibo has been forwarded more than 240,000 times, and the number of likes has exceeded 78,000 times.

Gulandi

Chongqing guy who won the popularity of "making stars in a new way"

Compared with his peers in other circles, Gu Landi, who was born in Chongqing in 1995, was quite unconventional from his debut to his popularity. Although he also participated in Iqiyi’s talent show "Youth has You", he actually made his debut before this program started: In the online drama "Love You So Sweet" of Tencent video last year, Gu Landi starred in the male No.2.

Gulandi

In January of this year, Youth with You, which has been regarded as the second season of Idol Trainee, was launched, and Gu Landi joined it as a trainee. After two months of competition, Gu Landi regretted stopping in the top 20, and something interesting happened at this time. He, together with Shi Mingze, Hu Wenxuan, Xu Bingchao and Ding Feijun, formed a men’s team named "D5, the fifth son of the desert" and announced his debut. The operation team behind it is Lehua Entertainment, which has previously launched the "NEXT of the Seven sons of Lehua" (the main members include THEO and Adam).

Displaying the Imperial Capital of Valley Blue is a "trainee" from Youth with You.

The key to saying that it is the result of the current "new game of making stars" is that "the fifth son of the desert D5" announced its existence for only three months at the same time from the date of its birth. Not only that, the unique significance of "Five Sons of the Desert D5" is that it is the first case of spontaneous group cooperation between artists from different companies. People in the industry generally believe that this has unlocked the new mode of idol draft, given the eliminated players new opportunities, and maintained the heat of the players after the game to a certain extent. At the same time of forming a group, "Desert Wuzi D5" has an official fan club, and the membership card valid for three months costs 99 yuan.

During the three-month existence of "Five Sons of the Desert D5", they released two singles successively, and they also appeared in the theme concert of "Burning Snow" in the 1000-day countdown to the Beijing Winter Olympics.

Upstream News chongqing morning post Reporter Qiu Jinxi

[Disclaimer] The texts, pictures, audio and video that are not marked with "Source: Upstream News-chongqing morning post" or "Upstream News LOGO" on the upstream news client are all reposted. If the reposted manuscript involves copyright issues, please contact the upstream news.

1905 movie network news Jumanji: The Next Level, a Hollywood action adventure masterpiece, will be released nationwide on December 6th, and the Brave Team led by "Stonestone" Qiang Sen will be assembled again. This time, the game world is completely out of control, the difficulty of the level is soaring, the visual wonders are escalating, and the lives of four people are hanging by a thread at any time.

On December 5th, the film released a special edition of "All-round Advanced", in which all the main creators appeared to show the interesting shooting process of the film, and all the people worked together to create higher-level works, which perfectly explained the spirit of the brave to challenge the peak. The film is directed by jack Kasdan, and Dwayne Douglas Johnson, Jack Black, kevin hart and Karen Sheila Gillan will return to the whole lineup.

The main creative staff appeared in the comprehensive advanced special edition. 　

Qi Xin, the brave, works together to fight the peak again.

In addition to the thrilling and funny clips of the film, the special edition also exposed the behind-the-scenes shooting tidbits for the first time, and the main creative staff made an appearance to tell about their expectations for the film. Qiang Sen, as the leading actor and producer, has very high requirements for this film: "If you are lucky enough to make a film as successful as the first Brave Game, you must get an by going up one flight of stairs when making a sequel."

For director jack Kasdan, he also wants to "fight the peak again": "We want to challenge ourselves and do something new that was not in the first movie." In order to present a fully upgraded game world, they challenged infinite possibilities during this shooting. Not only were the scenes more diverse and grand, but the actors also went beyond their physical limits.

The reunion of the whole excellent team inspired everyone’s creative inspiration, produced wonderful chemical effects, and created a series of jokes at the same time. For example, Qiang Sen played Grandpa Eddie, which made Awkwafina, who played a mysterious new role, very amazed. In addition, Dr. Yong Shi also met a more powerful opponent — — You Ergen, the cruel man, makes people wonder how the brave will fight against this "ultimate enemy".

"Man-Bird Wars" and "Speeding Cars" are frightening.　

Mouth gun partners love each other and kill each other, which brings laughter again and again　

The brave game world, which has returned to the audience’s field of vision, has ushered in a dangerous escalation and total loss of control, and the rapid transformation of a number of extremely thrilling new levels is dizzying. In addition to the primitive jungle where the man-eating hippopotamus is hidden in the previous work, there are endless abyss that kills people at any time, numerous peak forest pontoons besieged by wild mandrels, extremely cold snow-capped mountains that suddenly collapse and crack, and uninhabited desert & HELIP; …

The wild animals in the game world, such as wild mandrills, angry ostriches, man-eating pythons and ferocious hyenas, are lifelike and terrible, with clear hair expressions and 100% reduction; The ostrich gallops as if it were there, and the flying stones and gravel seem to be in front of it. The immersive visual experience brings the extreme stimulation that makes people’s adrenal glands soar.

At the same time, there are a lot of jokes in the film. Whether Qiang Sen plays a bad-tempered grandfather or kevin hart turns into an elegant old gentleman who speaks very slowly, Gao Fancha’s "laughter" is hilarious, and the two of them start the mode of love and killing each other along the way, which makes people laugh hysterically. In addition, the brave fought fiercely with the angry ostrich brigade and fought side by side with Bethany who turned into a dark horse. The super-burning group battle was exciting and full of jokes. It was a rare "effective" and funny masterpiece.

Global word-of-mouth harvest received rave reviews.　

"The biggest surprise of the year" triggered the expectation of the whole people.

"Jumanji: The Next Level" has been praised by the media since it was announced. Recently, it has been released in other regions and countries, and it has received numerous praises. As a sequel to Super IP, people feel full of sincerity: "It’s great to see such a wonderful sequel!" "Surprise, amazing! After reading it, I look forward to the follow-up development of IP. ""The most surprising, thrilling and sincere Hollywood action adventure blockbuster in 2019 "; The comprehensive upgrade of the visual spectacle is amazing: "This brave game world presents us with a shocking spectacle";

The wonderful performances of the leading actors won numerous praises: "The best partner of Qiang Sen and kevin hart is worth watching, and Awkwafina has excellent acting skills." "I can’t choose the best actor, because everyone in it performed super brilliantly, which makes people sincerely admire!" ; The film brings you thrilling and hilarious sensory enjoyment: "The film has brought me unexpected excitement and continuous laughter, which is simply a surprise everywhere!" The strong word-of-mouth given by local media and audiences has ignited the strong expectations of domestic fans for film release.

Short-listed for the Oscar for Best Visual Effects 　

Top production team to create "the most powerful film in the same file"

Recently, "Jumanji: The Next Level" was shortlisted for the Oscar for Best Visual Effects Award. The shocking visual effects presented in the preview attracted countless audiences, thanks to the top behind-the-scenes production team: more than 5,000 visual effects teams from all over the world created vivid details of fierce beasts;

Spectacular scenes and checkpoints full of imagination are manipulated by artists who have participated in special effects blockbusters; The Oscar-level visual effects director who participated in the production also participated in the production of this film, presenting the imaginary game world realistically and satisfying the dreams of countless people to enter the game world. Since the pre-sale of the film started last week, so far, the pre-sale box office has exceeded 10 million, and the pre-sale ratio ranks first, and other indicators such as wanting to see also take advantage, crushing the films released in the same file.

No matter from the aspects of IP popularity, production level, card lineup, etc., it can be called the strongest giant system at the end of the year. Newly upgraded levels and newly joined characters will present a novel and interesting sensory experience for everyone, which is definitely worthy of the title of the most anticipated Hollywood action adventure blockbuster at the end of the year.

Jumanji: The Next Level, a Hollywood action adventure masterpiece, is directed by jack Kasdan, and the four leading characters, Dr. Yong Shi Dwayne Douglas Johnson, geologist Jack Black, linguist kevin hart and sexy girl Karen Sheila Gillan, will return to the whole lineup! In order to save their lost companions, the Brave Four assembled again and entered an unknown world that was completely out of control. Facing the dangerous barrier of off the charts, Qiang Sen led the team to challenge the limit to escape. An adventure full of thrills and surprises is about to begin.

Everyone knows that Tik Tok is very popular, and live broadcast with goods can make money. Do you know about online celebrity, an e-commerce company in Tik Tok? Let’s take a look at Tik Tok’s ranking of online celebrity with goods together with Xiaobian.

In 2019, Tik Tok is still actively promoting the realization of e-commerce in Tik Tok. Following the list of good things in Tik Tok, Tik Tok officially launched the list of sales of talents recently, which has become the focus of Tik Tok operators. At present, the most popular people who carry goods in Tik Tok are: pomelo cici sauce, Li Jiaqi, Natiguli, Hao Fan, Ye Gongzi, Spicy Lai, good geophysicist and so on.

Even during the epidemic, many cities and roads were closed; However, the live broadcast of Devil Li Jiaqi was repeated after the festival. The live broadcast lasted for 3 hours, watched by 1,600 w+people, with 26,000 boxes of snail powder, 300,000 packs of washcloths and 150,000 bottles of Red Earth liquid foundation, all in seconds. Li Jiaqi, a lipstick brother, revealed in an interview that since January 2019, he has already entered 7 figures in a month by bringing goods through live broadcast;

Undoubtedly, live broadcast with goods has become a popular fried chicken for "selling goods". Live broadcast’s unique timely interaction, hunger marketing, transparent consumption scenes and all-round sensory impact make live broadcast with goods effectively promote the conversion rate and turnover of e-commerce and improve the efficiency of traffic realization.

Interesting content+real-time two-way interaction+the lowest price of the whole network+trust guarantee, and the consumer demand of users is stimulated.

Live broadcast helps e-commerce to change from "goods and people" to "people", and the relationship between anchors, goods and consumers is getting closer and closer.

The anchor sells people and explains to users, and users pay attention to and understand the products because they like an anchor, which enhances the exposure of products and then stimulates the purchase behavior.

The above is the 18183 Xiaobian’s ranking of Tik Tok e-commerce in online celebrity and Tik Tok in online celebrity. I hope it will help you.

Long-term recruitment of anchors: male or female, cheerful personality, talent and expertise are preferred, and network hosting experience is preferred. Novice Xiaobai can also do it. The company provides free training and arranges the live broadcast time and content according to personal ability. The strength of the company supports the application for anchor popularity and ensures the traffic in the live broadcast room.

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Tik Tok dry goods

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