[New Car Launch] LYNK&CO, a brand-new brand of Geely Group, officially released the Harmony. The new car is built on the CMA platform jointly developed by Geely and Geely, in which 01 will be officially mass-produced as the first model of LYNK&CO in 2017, and will be listed in China at the end of 2017. Meanwhile, the Lynk & Co brand will gradually enter the European and North American markets.

『LYNC&CO 01 concept car

『LYNK concept car

● LYNK&CO 01 concept car

　　LYNK&CO 01 concept car is located in a model, which is built by Gothenburg styling center led by Peter Hobury, deputy director of Geely Group, and its overall style is very fashionable. The large mouth air intake grille gives people a very layered feeling. At the same time, the headlight group adopts split design, in which the light band shape is very individual, while the high beam and low beam groups are hidden on both sides of the grille, which makes the front face of the whole vehicle look more integrated.

　　On the tail, the 01 concept car adopts L-shaped taillight design and LED light source, and presents a stereoscopic visual effect. The overall design is coordinated, the lines are full, and it doesn’t look stingy.

　　In terms of interior, the new car adopts a 10-inch full LCD instrument panel with mechanical instrument combination design, and is equipped with interior atmosphere lights, a 10.1-inch touch screen, an electronic shift lever, etc. to increase the sense of technology. On the whole, the new car focuses on Nordic style, and the design is simple and fashionable.

　　LYNK&CO brand official said that this concept car is "the product that best represents intelligent interconnection technology". Based on the open digital platform, it will cooperate with the world’s leading technology companies. Therefore, interconnection is also one of the main aspects of LYNK&CO brand in the future.

　　In terms of power, the new car will be equipped with 1.5T three-cylinder and 2.0T four-cylinder matched with CMA platform in the future, as well as hybrid system and pure electric system. In terms of transmission, it will be matched with a brand-new 7-speed, and the new car will also be equipped with a four-wheel drive system.

● LYNK concept car

　　Compared with LYNK&CO 01 concept car, this concept car named LYNK has no mass production plan. It is just an attempt by the designer for LYNK&CO brand. The new car adopts a four-door coupe design and looks very dynamic as a whole. The front face of the new car still uses a large mouth grille design, while the headlight group uses a more simplified LED light source. Compared with LYNK&CO 01 concept car, the new car has more muscular lines.

　　In terms of body, the new car adopts a four-door style that tilts upwards and looks very individual. In the tail shape, we can see the sense of movement of its design, and the taillight group adopts integrated light belt design, which gives people a very fashionable feeling.

　　In terms of interior, the concept car is even more exaggerated. The steering wheel with more sporty shape is equipped with a full LCD instrument panel and a central control LCD screen, which gives people a more futuristic feeling. At the same time, the 2+2-type four-seat chair looks very design-oriented.

● Introduction of CMA platform

　　With regard to the platform, the 01 concept car is built on the CMA modular platform of Geely Group. The CMA platform is a brand-new intermediate car basic module structure led by Volvo Cars and jointly developed by Geely Cars and Volvo Cars. The platform has been developed in the European Research and Development Center (CEVT) of Geely Cars for more than three years, and can be adjusted according to the positioning and length of different models, covering small, compact and corresponding product layouts. In the future, a new generation of Volvo 40 series models will be born on this platform.

◆ LYNK&CO brand introduction:

　　LYNK&CO brand is a brand-new brand created by Geely Group. Its positioning is between Geely brand and Volvo brand under the group, focusing on Nordic style, and it will become a competitor of overseas mainstream brands including and.

　　LYNK&CO is a combination of two English words. LYNK means connection and interconnection, which represents the cooperative nature of the brand and the future development route of intelligent interconnection. It is expected to join the ranks of future mobile travel service providers. CO has no specific meaning, its meaning is to make the brand name more catchy, thus showing that the new brand is young and full of vitality.

　　In the future, the brand will build matrix products based on CMA platform. The first production car will be a compact SUV, code-named C11, which will adopt the overall design language of 01 concept car. In the future, LYNK&CO brand will also enter the China market in the future, so as to compete with Volkswagen, Ford and other brands. (Text/car home Wuyuan)

　　Read more:

　　Promote smart interconnection? LYNK&CO’s latest trailer released

Transfer from: China Business Network.

Our reporter Yin Limei Tong Haihua reports from Beijing.

(601633.SH) In September this year, it sold 121,600 new cars, a year-on-year increase of 29.89%. From January to September this year, it sold a total of 864,000 new cars. On the evening of October 8, Great Wall Motor disclosed the above data.

"China Business News" reporter noted that the sales volume of Great Wall Motor in the first three quarters of 2023 "jumped three times in a row", achieving a step-by-step growth. In the first quarter, Great Wall Motor sold 220,000 vehicles; In the second quarter, the sales volume was 299,300 vehicles, an increase of 36.05% from the previous quarter; In the third quarter, the sales volume reached 344,800 vehicles, an increase of 15.22% from the previous quarter.

New energy vehicles play an increasingly important role in the annual sales of car companies. In the first three quarters of this year, Great Wall Motor sold a total of 170,300 new energy vehicles, a year-on-year increase of 75.77%; In the first, second and third quarters, the sales of new energy vehicles accounted for 12.64%, 21.86% and 22.37% respectively, showing a trend of increasing quarter by quarter. This shows that the long-term strategic achievements of Great Wall Motor have begun to appear.

Previously, Feng Mu, president of Great Wall Motor, told reporters that new energy vehicles have reached a critical juncture, and the bloodletting price war is definitely not a long-term solution. Only by persisting in long-term doctrine and making the system have the ability to make blood, can enterprises go further.

The reporter also noted that thanks to the intelligent new energy development strategy, the pace of Great Wall Motor’s overseas ecological going to sea has accelerated, and at the same time, high-end models have continued to grow, and Great Wall Motor’s product matrix has formed a structural high-quality development. From January to September, the total export volume of Great Wall Motor reached 211,700 vehicles, up 89.45% year-on-year; The sales volume of vehicles above 150,000 yuan reached 179,700 vehicles, up 98.49% year-on-year, and the brand continued to improve. In the first, second and third quarters, the overseas sales of Great Wall Motor accounted for 23.63%, 24.04% and 25.45% respectively, and the proportion continued to grow.

It can be seen that with the adjustment and upgrading of product structure, star models have been listed one after another, the sales channel network has been accelerated, and the global layout has been deepened. Great Wall Motor has pressed the development acceleration button.

In the third quarter, the top five brands were "all red"

Specifically, the Haval brand sold 73,800 vehicles in September, a year-on-year increase of 37%; Under the strategic blessing of intelligent new energy, Haval sold 203,300 new cars in the third quarter, an increase of 22% from the previous quarter. In the third quarter, the Haval brand launched its efforts in the off-road field, and successively released 2024 Haval Big Dogs and the new Haval H5, a large-scale all-purpose hard-core SUV. The Haval Raptors, a new energy off-road popularization, will also be listed on October 10, leading the new energy off-road SUV to enter the era of the whole people.

Weipai New Energy sold 14,800 vehicles in the third quarter. Since the launch of the six-seat comfortable electric SUV Blue Mountain DHT-PHEV, the popularity has continued to rise, with a cumulative sales volume of more than 24,000 vehicles. During the Chengdu Auto Show, Wei Gaoshan DHT-PHEV officially opened the reservation and will be listed in the near future. In terms of terminal ecology, Weipai currently has 285 terminal stores, including 167 brand-new image stores, and has accelerated the construction of a multi-level sales service network including 4S stores, city exhibition halls and supermarkets, and continuously deepened the pace of high-end development of Weipai.

The Euler brand sold 10,000 vehicles in September, up 31.77% year-on-year, and sold over 10,000 vehicles for five consecutive months, leading the way in the new energy women-friendly subdivision track. In the third quarter, the Euler brand ushered in 400,000 off-line vehicles, officially becoming the first female new energy vehicle brand in the world to break through 400,000 vehicles. In the third quarter, the Euler brand also released the 2023 Euler Ballet Cat, the 2023 Good Cat and the Good Cat GT Mulan Edition, creating a better travel experience for users with the continuous renewal of product quality and service ecology.

Tank brands sold a total of 18,000 vehicles in September, a year-on-year increase of 43.15%. With the blessing of medium and large luxury off-road new energy SUV tank 500 Hi4-T and 2024 tank 300, the tank sold 104,500 vehicles from January to September, up 17.22% year-on-year. At the same time, the tank brand achieved sales of 300,000 vehicles in only 33 months, setting a record for China off-road brands to achieve sales of 300,000 vehicles at the fastest time, ranking first in the sales list of off-road SUVs in China market. In addition, the second model based on the Hi4-T architecture, the medium and large-scale urban function off-road SUV tank 400 Hi4-T, was launched on September 25th to meet the needs of users for urban and off-road vehicles.

Great Wall pickup trucks sold 17,200 vehicles in September, and accumulated sales of 152,700 vehicles from January to September, up 6.5% year-on-year. From January to September, the domestic market share of the Great Wall pickup truck was close to 50%. For every two pickup trucks sold in China, one was the Great Wall pickup truck. Great Wall Gun sold 12,200 vehicles in September, with a cumulative sales volume of over 10,000 vehicles in 37 months, ranking first in pickup truck sales in China. In the third quarter, on the occasion of the fourth anniversary of the Great Wall Gun brand, the 500,000th vehicle was officially rolled off the assembly line, becoming the first high-end pickup truck brand in China to break through 500,000 vehicles, creating a new "Great Wall Gun Speed". Shanhai Gun Performance Edition, a large-scale high-performance luxury pickup truck owned by Great Wall Gun, will be pre-sold nationwide in mid-October after welcoming the world’s first show at Chengdu Auto Show.

The reporter is concerned that with the continuous efforts in the intelligent new energy track, the terminal channels of Great Wall Motor have developed rapidly, and its new energy terminals have reached 156 in August, and it is expected to grow to 1,200 during the year. The three major measures of matrix rejuvenation, channel expansion and service upgrade have worked together, and Great Wall Motor’s intelligent new energy has entered a period of rapid development.

Globalization has entered the era of "One Great Wall"

Overseas business is becoming an important part of car companies’ sales business. In the third quarter, Great Wall Motor sold 87,800 vehicles overseas, an increase of 21.97% from the previous month, accounting for 25.45% of the sales volume. From January to September, Great Wall Motor sold 211,700 vehicles overseas, up 89.45% year-on-year.

"While the sales volume of Great Wall Motor has steadily increased, it has focused on ‘(ONE GWM’ and implemented the strategy of’ Eco-going to Sea’ to achieve accelerated development overseas." Great Wall Motor said.

At the end of 2022, Great Wall Motor officially announced the "ONE GWM" global action plan, creating an aggregation channel with GWM parent brand as the leading category, and working together to achieve brand promotion. At this stage, the localization operation of Great Wall Motor overseas will pay more attention to the improvement of "quality", deepen the connotation of "ecological going out to sea" and create brand advantages.

It is reported that in the third quarter of 2023, Great Wall Motor accelerated the expansion of the international influence of the "GWM" brand. In August, Great Wall Motor successively released the "GWM" brand in Vietnam and Indonesia, realizing the comprehensive coverage of the core regional markets of ASEAN countries. In Latin America, the launch conference of GWM brand of Great Wall Motor and Haval H6 HEV was held in Mexico City, Mexico, marking the official entry of Great Wall Motor into the Mexican market.

In the era of "One Great Wall", Great Wall Motor adheres to the core of "intelligent new energy", and intelligent new energy technologies and products have become the key factors to promote the acceleration of going to sea.

The reporter learned that the five brands of Great Wall Motor have all gone to sea, and high-value intelligent new energy products such as Haval H6 New Energy, Tank 500 New Energy, Euler Good Cat and Wei Mocha PHEV are being accelerated to be put into overseas markets. Advanced new energy and intelligent technologies, such as Hi4, Hi4-T, autonomous driving and intelligent cockpit, will continue to make technical endorsements for the global models of Great Wall Motor.

It is reported that Haval H6, Haval JOLION, Haval Big Dog, Euler Good Cat, Tank 300, Great Wall Gun and other models have been listed in Cambodia, Vietnam, Brazil and other places.

At the same time, Great Wall Motor is also exporting high-end products to overseas markets. The Great Wall Motor Tank 500 has been listed in the Middle East market in succession in the United Arab Emirates, Saudi Arabia, Oman and Bahrain. In addition, in Central Asia, the listing of Tank 500 was held in Almaty, the largest city in Kazakhstan. In the ASEAN market, Tanks 300 and 500 are officially listed in Thailand.

Great Wall Motor’s vision is not only to launch products to overseas markets, but to practice the strategy of "going out to sea ecologically" and take root in overseas localization operations. Great Wall Motor has taken production and R&D abroad through the investment in overseas factories, improved the training and accumulation of local talents, and formed an all-round construction of overseas ecological and industrial chain.

At present, Great Wall Motor has formally signed a strategic cooperation agreement with ADM Automobile Factory of Uzbekistan Automobile Group on Uzbekistan’s market development cooperation, further accelerating the process of overseas localized production and sales of Great Wall Motor.

"In the future, with the outstanding achievements of Great Wall Motor’s intelligent new energy layout, Great Wall Motor will continue to accelerate the rejuvenation of intelligent new energy products with profound technical accumulation, continuously enhance the development potential of intelligent new energy, promote the upgrading of terminal services, accelerate the landing of the’ ecological sea-going’ model overseas, and push the development of enterprises to a new height." Great Wall Motor said.

(Editor: Zhang Shuo Proofreading: Yan Jingning)

The market is full of all kinds of products, but good products are rare. Huawei not only broke through the limit in the mobile phone industry, but also made Huawei Mate series a benchmark in the mobile phone industry. Recently, the new M7, a traffic upstart in the hot industry, has won the love and recognition of consumers in three aspects: intelligent driving, intelligent cockpit and intelligent safety with the help of HUAWEI ADS 2.0 advanced intelligent driving system and HarmonyOS Smart Cockpit 3.0, and has repeatedly set new records.

HUAWEI ADS 2.0 makes intelligence everywhere.

One of the most striking core technologies of the new M7 is the HUAWEI ADS 2.0 advanced intelligent driving system, which realizes the advanced intelligent driving experience without relying on high-precision maps. With the perfect combination of 27 powerful sensing hardware, high-performance computing platform and Huawei’s self-developed anthropomorphic algorithm, the new M7 in Wenjie presents unparalleled full-scene, all-weather accurate sensing and recognition capabilities for drivers. Whether it is dynamic moving targets or static road information, the new M7 can easily cope with the complex traffic environment and driving challenges.

At the same time, the new M7 in Wenjie adopts multi-sensors such as lidar and integrated sensing BEV and GOD 2.0+RCR 2.0 networks, which provides high perception, quick response and the ability to adapt to light and dark changes. This also enables the new M7 to perceive the world more powerfully, to perceive and monitor all kinds of complex road conditions in an all-round way, and its perception ability can not only be beyond the reach of the eye, but also understand complex road conditions independently, so as to achieve accurate response even if the attention is not concentrated or the road conditions are complex, and greatly reduce the incidence of traffic accidents.

What’s more worth mentioning is that in terms of intelligent driving, the new M7 in the world has upgraded a new intelligent extended range mode, which has brought drivers a more efficient way of energy utilization. Through the optimal oil and electricity distribution of intelligent control system, the vehicle can achieve the lowest energy consumption during driving, achieve the effect of saving fuel and electricity, and greatly reduce the driver’s endurance anxiety.

HarmonyOS Smart Cockpit 3.0 defines what a true smart cockpit is.

HarmonyOS Intelligent Cockpit 3.0, which is equipped with the new M7, brings unprecedented intelligent experience to drivers. The super desktop function provides drivers with a variety of audio-visual entertainment options, making driving time more enjoyable. By touching the screen, drivers can easily access various applications, music, movies and other entertainment content and enjoy a high-quality driving and entertainment experience.

With the powerful empowerment of HarmonyOS Zhixing depth technology, HarmonyOS Intelligent Cockpit 3.0 not only performs well in normal environment, but also shows its extraordinary stability under severe working conditions of extremely cold and low temperature. It has been verified by actual measurement that the operation and response of the cross-car machine remain silky and smooth even in the extremely cold climate, and its achievements are among the best in similar products.

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With the addition of Xiaoyi Smart Assistant and HUAWEI MagLink Smart Car Screen System, the intelligent experience of the new M7 has been greatly improved. The voice interactive service of Xiaoyi Smart Assistant provides drivers with convenient information acquisition and service reservation. Whether it is weather query, navigation or ordering, all operations become simple and convenient. The driver only needs to give instructions, and Xiaoyi will enter the voice interaction mode to provide smoother and more efficient services for the driver.

It is particularly worth mentioning that the HUAWEI MagLink smart car screen system not only realizes the connection without feeling on the Huawei tablet, but also creates a dedicated personal studio and conference room for users. This flexible cockpit space switching can not only meet the needs of the whole family to watch movies and entertain together, but also meet the needs of individuals to work independently, so that users can experience the diversity of space.

Intelligent and safe construction of travel barrier base

In the field of intelligent security, the new M7 has made remarkable achievements with its excellent performance. First of all, HUAWEI ADS 2.0, the world’s first omni-directional anti-collision system, has achieved omni-directional anti-collision capability in the forward direction, lateral direction and backward direction. With the multi-sensor fusion perception capability based on lidar, the system can identify common obstacles as road boundaries. Once the vehicle deviates from the lane or has collision risk, the system will automatically trigger emergency direction intervention or emergency braking to avoid potential collision risk.

Happily, in the AEB active safety evaluation of Autolab, Wenjie New M7 has won the championship in all kinds of active safety evaluation, and its safety response speed ranks among the top in the whole scene. In all kinds of complicated situations, including the mixed scene of stationary vehicles and pedestrians at the front and rear of the vehicle and rollover scenes, HUAWEI ADS 2.0 can reach the braking speed of 90km/h even at night, which improves its capacity by 50%, far ahead of other active safety systems in the industry. This series of innovations has enabled the new M7 to reach the ceiling level in terms of intelligent security performance.

In addition, the new M7 also has the function of identifying obstacles in advance and actively intervening, so that drivers can make timely deceleration or avoidance actions. In this way, the process of braking or avoiding is smoother, and the driving experience is smoother and calmer. Based on the powerful intelligent safety function, the new M7 in Wenjie successfully passed the active safety test project of knowing the winter test of Chedi 2023, and successfully completed the test in extreme scenes such as snow at night and backlight at night at a speed of 60km/h, and its excellent performance further consolidated the leading position of the new M7 in the field of intelligent safety.

With the help of Huawei’s deep empowerment, the world has won the title of "three smart ceilings" for intelligent driving, intelligent cockpit and intelligent safety, providing a more comprehensive guarantee for travel. In the future, the world will continue to adhere to innovation-driven and user-demand-oriented, constantly improve the technical level and user experience of smart travel, and lay a solid foundation for better smart travel.

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The 12th Volvo Ocean Race, which has attracted much attention, set sail again from Sanya, Hainan Province, China today to start the fourth stage race, thus opening the prelude to the strong development of Volvo Cars in China in 2015. Hanken samuelson, President and CEO of Volvo Car Group, announced that Volvo, a world-famous luxury car brand, is undergoing a global renaissance, and Volvo Car China entered the "Brand Year" in China in 2015 after two years of rapid growth. At the same time, Volvo "Nordic Luxury" will be accompanied by the new XC90 listing and differentiated brand combination boxing, realizing the revaluation and release of brand value, injecting new energy into the development of Volvo cars with a long history of 88 years in China, and the company’s "China growth strategy" will enter a new stage.

Hanken samuelson said at the launching ceremony: "Volvo is committed to becoming the most popular and enterprising luxury car brand in the world. Based on the three core values of safety, environmental protection and quality, it is demonstrating its strong innovation capability in the fields of air quality inside cars, new energy vehicles, autonomous driving and car networking, and big data. China is Volvo’s second hometown and Volvo’s largest market in the world. We have completed the first stage of development in China and are starting a new stage of’ China Growth Strategy’. China’s economic transformation and upgrading and the change of consumers’ values will provide a historic opportunity for Volvo’s development in China. By actively exploring the China market and strengthening the American market and the European market, our goal is to achieve sales of 800,000 units in 2020 and realize the vision of’ zero casualties’ and’ zero emissions’. "

Lars Deng, global senior vice president of Volvo Car Group and CEO of China, said, "In the past decade, China’s share in the global market of Volvo Cars has increased from a paltry 1% in 2005 to 17% by the end of 2014, making it the largest market of Volvo Cars. Our medium-term goal is to double the existing market share to 10% and achieve annual sales of 200,000 vehicles. In the future, we will continue to recover lost ground and gain a market position consistent with our brand strength with a more confident attitude. "

2014 is the "Wonderful Year of China" for Volvo Cars. The company’s sales in the world and China both reached record highs, and announced a new global marketing strategy with the core of increasing marketing investment, testing e-commerce and enhancing the accuracy and depth of brand experience. In 2014, the company sold 81,221 vehicles in China, a year-on-year increase of 32.8%, exceeding the annual sales target of 80,000 vehicles. In January this year, Volvo Cars achieved 19 consecutive months of growth worldwide, continuing the strong pace of global rejuvenation.

"Nordic Luxury" is confident to open up the China market

2014 is the core year for Volvo Cars to achieve the first phase of its "China Growth Strategy". The company has made great progress in sales, network, industrial system, product planning, brand building and organizational development.

Fu Qiang, President and CEO of Volvo Car China Sales Company, said: "The strong sales growth in the past decade fully shows that Volvo has been fully recognized by consumers in terms of product quality and brand value. In the new stage of’ China Growth Strategy’, with awe, we take 2015 as a new starting point and constantly dust off the Volvo brand, so that it will shine more brightly in the new journey. " He said, "Volvo is not only a luxury car brand full of beauty and affection, but also a technology and innovation brand full of passion and determination."

Fu Qiang said, "Although there are challenges in the luxury car market in China in 2015, Volvo will take the opportunity of’ Brand Year’ to build a brand from five aspects:’ One Entry (brand new XC90 is listed in China) and One Exit (exported to the United States)’,’ Volvo Way’ Nordic luxury experience, technology sub-brand release, car intelligence and new marketing strategy, so as to make Volvo’s image in the luxury camp clearer, more enterprising and more enterprising. Volvo has never been a follower. We have the strength and confidence to establish the image of a first-class luxury brand in China and embark on a new stage of comprehensive brand rejuvenation with the support of consumers. "

In 2015, Volvo’s powerful products to be listed in China include the first landmark new luxury flagship produced by the company with an investment of US$ 11 billion-Volvo’s brand-new XC90, the luxury plug-in hybrid vehicle S60L PHEV made in China for the first time, and the luxury crossover vehicle V60 Cross Country, and other 11 new and modified models. In addition, the company will also introduce self-driving demonstration projects in China, Volvo Ocean Race, Volvo China Open, etc., and will export domestic S60L to the United States within this year, which will be the first time that Volvo, as a representative of China’s advanced manufacturing industry, exports luxury car products to developed countries.

Lars Deng said, "As a brand with profound historical accumulation, Volvo will reshape and upgrade its brand in the new development stage. Adhering to the concept of’ people-oriented’, we will bring consumers a more unique customer experience through innovative marketing, drive and realize the new progress of’ China Growth Strategy’, and welcome the arrival of a new era in the luxury car market in China. "

"People-oriented" will become the mainstream values to drive the global rejuvenation of the brand.

Volvo brand originated from northern Europe, and it is the region with the highest "happiness index" in the world. In this desirable land, people embrace nature, are eager for quality, have a good relaxation, and have a perfect balance between work and family. Volvo’s "respect for people" is exactly the same as the essence of this happy and pure living state.

At the Volvo Brand and Lifestyle Forum of Volvo Ocean Race held in sanya station on the morning of February 7th, Thomas Ingrat, Senior Vice President of Global Design of Volvo Car Group, said: "Nordic luxury is an embrace of nature, and it is the best explanation that technology serves people. Volvo is not only an excellent’ driving machine’, but also endowed the car with emotion and soul by virtue of’ respecting people’. Understanding of Volvo through intelligent technology for drivers and passengers’ protection of life’, but also to’ quality of life’ to bring emotional experience and care to users. Volvo’s brand-new design language perfectly explains the brand value of’ people-oriented’. As China consumers continue to mature, the elegant Nordic design, which embodies the perfect combination of functionality and aesthetics, will go to the center of the stage and be appreciated and respected by more China consumers. "

Mr. Thomas Ingrat, Senior Vice President of Design of Volvo Car Group, shared the new Volvo XC90 design concept and explained the Nordic luxury in every detail.

Li Shuanke, a researcher at the Institute of Geographical Sciences and Resources of the Chinese Academy of Sciences and the president and editor-in-chief of chinese national geography magazine, said at the forum: "The sailing displayed in the Volvo Ocean Race is an exploration of the unknown and a respect for nature. Volvo introduced sailing, a brand-new way of life, into China, which reflected the origin of the brand, advocated a natural and healthy lifestyle and grasped the trend. "

He said that in China, where values are undergoing profound changes, people need to improve their spiritual prosperity after accumulating wealth. With the transformation of China society from "rich to expensive" and "from expensive to polite", the new lifestyle represented by self-improvement and self-improvement will gradually become the mainstream, and gradually replace the way of showing off sexual life and consumption concept. "This is a unique opportunity for Volvo to develop in China".

It perfectly explains the brand value of "people-oriented".

Volvo is an advocate of the concept of "putting people first" and a happy life in Northern Europe, and is committed to bringing a positive and healthy attitude and behavior to the elite in China. As a participant in the return of mainstream social values, Volvo has established and is strengthening its differentiated advantages from other luxury brands. With the continuous progress of China society, the life realm and grand pattern that Volvo adheres to and advocates will play an important role in the social evolution and commercial civilization development of China under the guidance of "Brand Year".

"Nordic Luxury" is confident to open up the China market

2014 is the core year for Volvo Cars to achieve the first phase of its "China Growth Strategy". The company has made great progress in sales, network, industrial system, product planning, brand building and organizational development.

Fu Qiang, President and CEO of Volvo Car China Sales Company, said: "The strong sales growth in the past decade fully shows that Volvo has been fully recognized by consumers in terms of product quality and brand value. In the new stage of’ China Growth Strategy’, with awe, we take 2015 as a new starting point and constantly dust off the Volvo brand, so that it will shine more brightly in the new journey. " He said, "Volvo is not only a luxury car brand full of beauty and affection, but also a technology and innovation brand full of passion and determination."

Fu Qiang said, "Although there are challenges in the luxury car market in China in 2015, Volvo will take the opportunity of’ Brand Year’ to build a brand from five aspects:’ One Entry (brand new XC90 is listed in China) and One Exit (exported to the United States)’,’ Volvo Way’ Nordic luxury experience, technology sub-brand release, car intelligence and new marketing strategy, so as to make Volvo’s image in the luxury camp clearer, more enterprising and more enterprising. Volvo has never been a follower. We have the strength and confidence to establish the image of a first-class luxury brand in China and embark on a new stage of comprehensive brand rejuvenation with the support of consumers. "

In 2015, Volvo’s powerful products to be listed in China include the first landmark new luxury flagship produced by the company with an investment of US$ 11 billion-Volvo’s brand-new XC90, the luxury plug-in hybrid vehicle S60L PHEV made in China for the first time, and the luxury crossover vehicle V60 Cross Country, and other 11 new and modified models. In addition, the company will also introduce self-driving demonstration projects in China, Volvo Ocean Race, Volvo China Open, etc., and will export domestic S60L to the United States within this year, which will be the first time that Volvo, as a representative of China’s advanced manufacturing industry, exports luxury car products to developed countries.

Lars Deng said, "As a brand with profound historical accumulation, Volvo will reshape and upgrade its brand in the new development stage. Adhering to the concept of’ people-oriented’, we will bring consumers a more unique customer experience through innovative marketing, drive and realize the new progress of’ China Growth Strategy’, and welcome the arrival of a new era in the luxury car market in China. "

"People-oriented" will become the mainstream values to drive the global rejuvenation of the brand.

Volvo brand originated from northern Europe, and it is the region with the highest "happiness index" in the world. In this desirable land, people embrace nature, are eager for quality, have a good relaxation, and have a perfect balance between work and family. Volvo’s "respect for people" is exactly the same as the essence of this happy and pure living state.

At the Volvo Brand and Lifestyle Forum of Volvo Ocean Race held in sanya station on the morning of February 7th, Thomas Ingrat, Senior Vice President of Global Design of Volvo Car Group, said: "Nordic luxury is an embrace of nature, and it is the best explanation that technology serves people. Volvo is not only an excellent’ driving machine’, but also endowed the car with emotion and soul by virtue of’ respecting people’. Understanding of Volvo through intelligent technology for drivers and passengers’ protection of life’, but also to’ quality of life’ to bring emotional experience and care to users. Volvo’s brand-new design language perfectly explains the brand value of’ people-oriented’. As China consumers continue to mature, the elegant Nordic design, which embodies the perfect combination of functionality and aesthetics, will go to the center of the stage and be appreciated and respected by more China consumers. "

Mr. Thomas Ingrat, Senior Vice President of Design of Volvo Car Group, shared the new Volvo XC90 design concept and explained the Nordic luxury in every detail.

Li Shuanke, a researcher at the Institute of Geographical Sciences and Resources of the Chinese Academy of Sciences and the president and editor-in-chief of chinese national geography magazine, said at the forum: "The sailing displayed in the Volvo Ocean Race is an exploration of the unknown and a respect for nature. Volvo introduced sailing, a brand-new way of life, into China, which reflected the origin of the brand, advocated a natural and healthy lifestyle and grasped the trend. "

He said that in China, where values are undergoing profound changes, people need to improve their spiritual prosperity after accumulating wealth. With the transformation of China society from "rich to expensive" and "from expensive to polite", the new lifestyle represented by self-improvement and self-improvement will gradually become the mainstream, and gradually replace the way of showing off sexual life and consumption concept. "This is a unique opportunity for Volvo to develop in China".

It perfectly explains the brand value of "people-oriented".

Volvo is an advocate of the concept of "putting people first" and a happy life in Northern Europe, and is committed to bringing a positive and healthy attitude and behavior to the elite in China. As a participant in the return of mainstream social values, Volvo has established and is strengthening its differentiated advantages from other luxury brands. With the continuous progress of China society, the life realm and grand pattern that Volvo adheres to and advocates will play an important role in the social evolution and commercial civilization development of China under the guidance of "Brand Year".

[car home Jinhua Preferential Promotion Channel] Good news, preferential promotion activities are being carried out in Jinhua area! The current maximum discount for this model is 13,000, and the minimum starting price is 113,900. If you are interested in this model, you may wish to click "Check the car price" in the quotation form to get a higher discount.

Tiggo 8 PRO is a medium-sized SUV, and its design is very fashionable and dynamic. The front part of the car adopts a large-area air intake grille, with sharp LED headlights and fog lights, creating a very domineering visual effect. The body lines are smooth and strong, and the overall style is very tough. The side of the car body is decorated with smooth lines and chrome plating, which makes the car body more exquisite. Through taillights are used in the rear part, which makes the whole rear look very fashionable. In addition, the Tiggo 8 PRO is also equipped with 18-inch wheels to make the whole car look more stable. On the whole, the design of Tiggo 8 PRO is excellent, which is not only fashionable and dynamic, but also very powerful, which is very in line with the aesthetic needs of modern consumers.

Tiggo 8 PRO is a medium-sized SUV. Its body size is 4745mm long, 1860mm wide and 1745mm high, with a wheelbase of 2710mm and front and rear wheel tracks of 1582mm and 1604mm respectively. The lines on the side of the car are smooth, showing a tough and fashionable feeling as a whole. Before and after tyre size are the same, both are 235/55 R18. Tire brands can choose different brands and models to meet different driving needs. In addition, the rim style of the Tiggo 8 PRO is also very unique, adopting a multi-spoke shape to make the vehicle look more dynamic. In short, the side design of the Tiggo 8 PRO is simple and atmospheric, which shows the strength and stability of the medium-sized SUV.

The interior design of the Tiggo 8 PRO is full of modernity. The central control screen size is 12.3 inches. It is equipped with a voice recognition control system, which can easily control multimedia systems, navigation, telephones, air conditioners and skylights. The steering wheel is made of leather and supports manual up and down+forward and backward adjustment, so that the driver can easily find the most comfortable position. The front and rear rows are equipped with USB and Type-C interfaces, which is convenient for passengers to charge. The front row is also equipped with a mobile phone wireless charging function. The seat is made of imitation leather. The main seat supports front-back adjustment, backrest adjustment and height adjustment (2-way), and the auxiliary seat also supports front-back adjustment and backrest adjustment. The second row of seats supports backrest adjustment, and the rear seats can also be tilted in proportion, which increases the practicability of the vehicle.

The Tiggo 8 PRO is equipped with a 1.6T 197 HP L4 engine with a maximum power of 145kW and a maximum torque of 290N·m, and is equipped with a 7-speed wet dual-clutch gearbox. This engine has excellent performance and can provide strong power output for vehicles. At the same time, the addition of 7-speed wet dual-clutch gearbox also provides drivers with a smoother shift experience.

In the eyes of car home car owners, the design of Tiggo 8 PRO is excellent, which is not inferior to other models of Chery in recent years. He believes that the design of the Tiggo 8 PRO has high aesthetics, especially the black body, which gives people an atmospheric feeling. However, he also mentioned a problem that needs attention, that is, the black body is easy to get dirty. Overall, the owner is satisfied with the design of Tiggo 8 PRO. We believe that with the use and evaluation of more car owners, the reputation of Tiggo 8 PRO will become more and more rich and true, and it will also provide consumers with more car purchase references.

On June 26th, BYD’s new generation Tang officially went on sale. The price range of fuel version was 129,900-169,900 yuan, and the price range of DM (dual-mode) version was 239,900-279,900 yuan.

A new generation of Tang adopted a new design concept in appearance design — — Designed by Dragon Face. This new design language, which combines Chinese and western industrial design aesthetics, is inspired by China’s traditional totem — — Dragon, supplemented by three key words of "impression", "technology" and "culture" as the core, finally formed a new design concept of "Dynasty car system". The integrated LED "double" seamless taillight design is another highlight of the new generation of Tang.

In terms of interior design, simple style is adopted. Among them, the 14.6-inch central control large screen that can rotate 90 degrees has naturally become the biggest highlight of the interior design of the whole vehicle. The screen can also adapt to the "horizontal and vertical" usage scenarios of smart phones. In addition, the new generation of Tang also provides DiLink intelligent network system, which supports various App downloads.

In terms of power, the new generation of Tang fuel version is equipped with a 2.0T turbocharged engine; The new generation Tang DM power system consists of a 2.0T turbocharged engine and a dual-drive motor.

In addition, the new generation of Tang EV (pure electric version) is expected to be launched at the end of 2018.

　　Recently, Chery Group released an August sales report. In August, Chery Group sold 65,200 vehicles, up 33.2% from the previous month and 5.4% from the same period last year. Among them, the sales volume of self-owned brand models was 52,000 units, up 23.1% from the previous month and 3.8% from the same period last year.

　　From January to August this year, Chery Group sold a total of 439,000 vehicles, including 378,000 vehicles of its own brand, up 5.9% year-on-year. Since the beginning of this year, the market share of Chery products has continued to increase. In July, the independent market share reached 4.27%, and 29 provinces achieved positive growth year-on-year, 56 cities doubled year-on-year, and 270 cities experienced positive growth year-on-year.

　　In terms of specific products, Chery’s two star cars, Tiggo and Arrizo, performed well. The sales volume of Tiggo SUV series was 21,081, of which the sales volume of the new generation Tiggo 8 was 10,340, up 11.9% from the previous month and 43.9% from the same period last year. Tiggo 5x sold 6,320 vehicles, up 51.7% from the previous month and 57.1% year-on-year. Arrizo series cars sold 8712 cars, of which the new Arrizo 5 sold 4600 cars and the Arrizo GX sold 4112 cars.

　　In the case of the overall decline of the domestic auto market, Chery Automobile can maintain the continuous growth of sales, thanks to the steady improvement in products, quality and channels.

　　System support product strength has been greatly improved.

　　Based on the perfect system capability and abundant technology accumulation, in recent years, the iteration speed of Chery’s new products and the upgrading speed of its old products have been significantly accelerated. Tiggo SUV series and Arrizo series products have been fully upgraded in design (modeling, appearance and interior decoration), power, intelligent networking and intelligent driving technology, including the third-generation engine, "Lion Zhiyun" intelligent networking system, intelligent assisted driving and other leading technologies, and their competitiveness has been greatly improved.

　　Taking the new generation of Tiggo 8 as an example, it is equipped with Chery’s third-generation ACTECO 1.6TGDI in-cylinder direct injection turbocharged engine, and its power performance level has achieved a qualitative leap; At the same time, for the first time, it was equipped with dozens of super smart configurations, including full-speed ACC adaptive cruise system including L2 intelligent assisted driving, APA automatic parking, LKA lane keeping, etc., which were very popular among young consumers. After three months of listing, sales continued to climb, and sales in August successfully exceeded 10,000.

　　A new generation of Tiggo 8

　　Ariza GX Pro

　　Improve quality and catch up with the level of joint venture brands in an all-round way.

　　In recent years, by strengthening the construction of total quality management system, Chery has effectively guaranteed the quality of new products, including the new generation of Tiggo 8, Tiggo 5x, Arrizo GX PRO, Arrizo 5 PRO and other new products, which are in the forefront of the industry in terms of product design, performance and reliability. At present, the 3MIS IPTV(3 of Chery’s new products has far exceeded the industry average and the level of some mainstream joint venture brands.

　　In the "2019 New Car Quality Survey Report" released by J.D.Power not long ago, Chery reached the average level of international brands with 92 points, and the brand ranking was 26 places higher than last year.

　　At the just-concluded national TQM promotion and the 40th anniversary of the founding of china association for quality, Chery Automobile Co., Ltd. was awarded the title of "Outstanding Promotion Unit for the 40th Anniversary of TQM Promotion" and "Annual National Quality and Technology Progress Award", and Chery’s "Seeking Truth from Facts QC Team" was awarded the title of "National Excellent Quality Management Team".

　　Channel promotion online and offline comprehensive empowerment

　　After entering 2019, Chery further improved the channel quality and formulated a first-level network to improve quality; The secondary network ensures the vertical penetration of the "super deep-sea plan", and the network scale has risen steadily. Up to now, the scale of Chery’s first network has stabilized at 500, and the scale of the second network has reached 1300. The dealers of the new network have grown rapidly, which has strongly supported the sales growth.

　　At the same time, Chery is also actively testing new retail models, cooperating with many new auto retail platforms, integrating customers’ big data, artificial intelligence and other resources, and actively improving users’ car purchase experience. In August this year, Tiggo 7i officially landed in Tmall and participated in the "Tmall 99" event. Consumers can make an appointment to pick up the car at the nearest Chery store by paying the deposit online through Tmall platform, and experience the new car purchase service model jointly built by Chery and Tmall, making the whole car purchase process more efficient and convenient.

　　In September, in order to thank the friends who have trusted Chery for many years, Chery specially launched the golden autumn car purchase preferential activities for consumers all over the country. During the event, all the designated models such as the new generation Tiggo 8, Tiggo 5x HERO, Arrizo GX Pro and Arrizo 5 Pro can enjoy high discounts. Among them, the new generation of Tiggo 8 can enjoy a maximum replacement subsidy of 10,000 yuan, and the Arrizo series can enjoy 0 down payment, 0 interest rate and 0 waiting time limit.

　　In this golden September, silver and ten automobile industry sales season, driven by product upgrading, quality improvement and channel improvement, as well as the release of a series of preferential policies, it is believed that Chery Automobile will continue to maintain the momentum of contrarian growth and become the backbone of China automobile brand.?

On October 26th, at the Xiaomi new product launch conference, Xiaomi 14 Pro was officially released in the long-awaited event. The performance, image and quality of congruent-depth micro-curved screen, Xiaomi Longjing glass, Leica optical summilux lens and the third-generation Snapdragon 8 mobile platform have been comprehensively upgraded by leaps and bounds, and the comprehensive strength has gone further. The new products have lived up to the expectations of rice noodles and brought the charm of high-end flagship to the extreme.

Outstanding appearance of technological innovation

As the main supplier of glass back cover and metal middle frame of Xiaomi 14 Pro series mobile phones, Bourne Optics has always played an outstanding role, and together with Xiaomi, it has created a high-end flagship machine with amazing face value and extraordinary performance!

Xiaomi 14 Pro has three colors: white, black and rock blue. Bourne Optics exclusively supplies Xiaomi 14 Pro black and rock blue back cover. The black back cover is the first brand-new sandblasting AG process developed and designed by Bourne Optics and Xiaomi. Let the glass backboard keep the silky and delicate touch, at the same time, it has the graininess of frosting, and when it is turned lightly, it reveals a little luster, making each light soft and stable.

The new design concept and new technology require extremely strict parameters. Bourne Optics set up a special project team to tackle the research and development with customers, and conducted analysis and verification for more than two months and rounds, ranging from the whole process design to the accurate 1 second time difference and 1 temperature difference, giving each color a high-definition beauty.

The beauty of science and technology tends to the extreme.

Xiaomi 14 Pro’s unique and innovative technology optimizes the multi-layer stress of the panel, and the four sides and corners are bent in equal depth to form a beautiful arc. Light up the screen and have a borderless vision; Hold it in your hand and bring a cobblestone touch.

Paris nail deco shines with exquisite charm.

The brand-new Leica optical Summilux lens is adopted. The lens module is designed as a rounded rectangle, the top of the metal ring is treated with Paris nail pattern, and the side surface is polished, which is visually unified with the camera module on the back. The middle frame is a right angle without radian, which makes the whole fuselage look more tough and stylish.

Elegant and light design of high strength aluminum alloy metal middle frame

The biggest highlight of Xiaomi 14 Pro this time is the use of high-strength aluminum alloy metal middle frame, and the introduction of high-brightness anodized surface treatment process to make the sense and feel better. As the main supplier of the metal middle frame of Xiaomi 14 Pro mobile phone, Bourne Optics cooperated with Xiaomi team to carve every detail carefully, put forward more than 20 verification schemes, and developed and verified 100 polishing consumables (sponge sand, polishing wheel, polishing wax, polishing skin, polishing liquid and anti-corrosion liquid) for five months, finally locking the current polishing process. With strong R&D and precision manufacturing capabilities to overcome difficulties, every opening of the metal frame is smooth and delicate, and the simple lines perfectly fit the textured back cover, making Xiaomi 14 Pro exquisite and eye-catching.

Join hands to explore more exciting

From 2012 to 2023, Bourne Optics and Xiaomi started in-depth cooperation, established a joint laboratory and created a number of classic products. The successful application of new technologies and processes on Xiaomi 14 Pro at this conference has become another milestone in the cooperation between the two parties. In the future, Bourne Optics will continue to strengthen its independent innovation capability, continue to develop high-tech technologies, and explore more wonderful things together with Xiaomi with exquisite manufacturing technology.

　 　 　 　Luo Jing, the host of the famous News Network, Cindy Lee, the actor who plays Fang Yu in Deep Rain, and Fuck off! Tumor jun touched many netizens’ cartoonist Xiong Dun … In recent years, many celebrities have passed away because of lymphoma. At the same time, however, there are also many famous people who have succeeded in fighting cancer after suffering from lymphoma. For example, the 70-year-old famous director Wu Yusen was diagnosed with large B-cell lymphoma in tonsils when filming Taiping Wheel in 2008. After four operations, in the second month of chemotherapy, his mouth was all festered, he could not swallow, and his body and face were so thin that he was wrinkled. Finally, he succeeded in fighting cancer with his firm will! 　

　 　 　 　For example, Kai-Fu Lee, the founder of an innovative factory that successfully used chemotherapy and targeted therapy to fight advanced lymphoma! On September 5, 2013, 52-year-old Kai-fu Lee announced that he had stage IV follicular lymphoma and had to leave work for treatment. In February 2015, he announced the results of his physical examination, indicating that the tumor in the body is not obvious at present. In June of the same year, Kai-fu Lee said that he had not found any lesions in his last two examinations and ridiculed himself as "Li Kangfu". It took Kai-fu Lee less than two years from finding out the cancer until the focus was completely gone. His anti-cancer experience is worth learning from.

Alias "the most disguised disease", lymphoma has become a killer.

　 　 　 　According to statistics, there is a new case of lymphoma every 9 minutes in the world. The incidence of lymphoma in China is 0.02‰, with about 25,000 new patients and nearly 20,000 deaths each year. The threat of lymphoma is rapidly emerging. It ranks among the top ten malignant tumors in China and ranks second among hematological malignancies. At the beginning, the symptoms of the disease were hidden, and it was described as "the most disguised disease". In the intercontinental area, the incidence of non-Hodgkin’s lymphoma is much higher than Hodgkin’s disease, which is about 9: 1. Because of the higher degree of malignancy and worse prognosis, lymphoma is generally referred to as non-Hodgkin’s lymphoma. In China, the incidence of malignant tumors ranks ninth among men and tenth among women. Non-Hodgkin’s lymphoma can occur in all ages, and the high incidence age is 45~60 years old. Among them, Luo Jing suffered from diffuse large B-cell lymphoma (DLBCL). This is a common non-Hodgkin’s lymphoma, which belongs to aggressive lymphoma with high malignancy. The course of the disease progresses rapidly. If it is not actively treated, the median survival time is less than one year. In recent years, great progress has been made in the research and treatment of lymphoma, and new drugs and technologies have risen strongly! CAR-T therapy Among them, the chimeric antigen receptor T(CAR-T) cell therapy is particularly prominent. Its appearance represents a great progress in personalized cancer treatment, especially bringing the hope of rebirth to patients with hematological malignancies.

Complete remission! The first advanced lymphoma patient in China who received CAR-T therapy was discharged smoothly!

　 　 　 　Although they all suffer from diffuse large B-cell lymphoma, Mr. Chen, who suffers from malignant lymphoma, is a lucky one. According to Jiangsu public news channel News Space Station, on August 31st, the first lymphoma patient treated with CAR-T cells in China achieved complete remission and was discharged smoothly. 　

　 　 　 　Mr. Chen suffered from diffuse large B-cell lymphoma. After the onset of the disease in October 2010, he had received chemotherapy for many times, but all of them were unsatisfactory. Diffuse large B-cell lymphoma is the most common malignant lymphoma. After immunotherapy, about 60% patients can survive for a long time, but 40% patients will still relapse. In June this year, Mr. Chen accepted CAR-T cell therapy with a tentative attitude, and all the physical indicators tended to be normal. He told reporters with delight that his physical condition was better than before, and he was no different from a normal person after leaving the hospital. CAR-T therapy, a "living drug", made her completely relieved and looked forward to a cancer-free future.　

　 　 　 　As a "living" drug, CAR-T therapy is very different from traditional drugs. First, the therapy needs to isolate T cells from patients and modify them with chimeric antigen receptor (CAR) in vitro, so that they can specifically recognize cancer cells. Finally, the modified T cells are expanded and reinfused into patients. Compared with traditional chemotherapy and hematopoietic stem cell transplantation, it can kill tumor cells more accurately, improve the curative effect and greatly reduce the side effects. 　

The well-known director of hematology in China said: CAR-T can identify lymphoma very deliberately, and the antigen carried on tumor cells will attack directly after being connected, and it will produce an anti-tumor effect and kill it directly without the need for second signal stimulation, so one of its characteristics is accuracy, and the second is power. The scope of application is still the recurrence or refractory diffuse large B lymphoma that is ineffective in general immunochemotherapy. 　

CAR-T therapy FDA approved 6 models, and domestic CAR-T therapy caught up! 　　　

　 　 　 　After sharing the above news reports about CAR-T therapy, let’s get down to business and talk about CAR-T therapy. At present,CAR-T therapy has achieved great success in the treatment of hematological malignancies.. Six CAR-T cell therapies have been approved by FDA in the United States and two CAR-T cell therapies have been listed in China. The picture below shows CAR-T cell therapy that has been listed at home and abroad. 　 　　

　 　 　 　Although China’s CAR-T technology started late, the domestic market is large. According to the data on Clinicaltrials.gov’s website, China became the country that registered the most CAR-T tests in September 2017. As of May 27th, 2021, there are 1301 CAR-T clinical trials in the world, and the number of CAR-T trials registered in China has reached 478!　

01　　The first CAR-T therapy in China was approved for listing! China welcomes the first year of cellular immunotherapy.

　 　 　 　On June 22nd, the blank in the field of CAR-T in China was finally broken! The latest announcement of China National Medical Products Administration (NMPA), Fosun Kaite Biotechnology Co., Ltd. (hereinafter referred to as " Fosun Kate ”） The CAR-T cell therapy product targeting CD19, Aquilencel Injection (also known as Aquilencel, FKC876), was officially approved for marketing. This is the first approved CAR-T therapy in China and the sixth approved CAR-T therapy in the world. It is believed that China will usher in the blowout era of CAR-T cell therapy.　

02　　In just one month, the second CAR-T therapy in China and the sixth CAR-T therapy in the world were approved!

　 　 　 　On September 3, the State Drug Administration recently announced that Yaoming JunuoThe CAR-T product targeting CD19, Regiosai Injection.(relma-cel, trade name: Benoda) has been officially approved. The approved indications for Regioside Injection are:It can be used to treat relapsed or refractory large B-cell lymphoma (r/r LBCL) in adult patients after second-line or above systemic treatment.Reggiorense injection is the second CAR-T product approved in China and the first CAR-T product of Class 1 biological products in China.

　

It’s only been about one month since it was submitted for examination and approval on July 30th last time, which can be described as rapid progress. Congratulations! (At present, patients with economic conditions can contact cancer-free homes for the treatment of regiorense. )　

Boom! The first BCMA CAR-T therapy in China and the second in the world was approved by FDA!

　 　 　 　China’s "dark horse" in CAR-T cell therapy industry-legendary BCMA(B-cell mature antigen) CAR-T therapy Cedar-B38m/JNJ-4528 (hereinafter referred to as cilta-cel) has attracted much attention, and has shown excellent anticancer activity in clinical trials for multiple myeloma.

　 　 　 　What is exciting is that on February 28th, 2022, local time, it was jointly developed by Janssen and Legendary Biology.BCMA CAR-T product, Cedactylosin (trade name Carvykti), has been approved by the US FDA for the treatment of adult patients with relapsed/refractory multiple myeloma (MM).

This is the first cell therapy product approved by FDA in China and the second CAR-T cell immunotherapy approved for BCMA in the world.

　

　 　 　 　Cilta-cel was awarded priority review qualification by FDA on May 26th.However, the approval of the West Dachiorensai was delayed, and it was adjusted from November 29, 2021 toFebruary 28, 2022Fortunately, it was finally approved and lived up to expectations!

　 　 　 　cilta-celIt is a CAR-T therapy directed by research B cell maturation antigen (BCMA), which is used to treat relapsed or refractory multiple myeloma (RRMM). These patients received an average of five kinds of pre-treatment before treatment, 76% of them received five kinds of treatment, and 86% of them were resistant to five kinds of treatment, including CD38 treatment, and they were both resistant to protease inhibitor PI and immunomodulator IMiD. Simply put, it is refractory to relapse and lack of effective treatment in the follow-up. The principle of this CAR-T therapy is different from the current PD-1/L1. It directly uses the T cells in the patient’s body, transforms them in vitro, replicates them in large quantities, and then transfuses them into the patient’s body to kill cancer cells. At the ASH conference in 2021, the latest results of the 1b/2 CARTITUDE-1 study (n=97) showed that,meso-position 22 months Long-term follow-up, The objective remission rate (ORR) reached 98% , 83% patients achieved strict complete remission (sCR) It is emphasized that the mitigation will deepen with the passage of time (sCR will increase from 67% reported at the ASH annual meeting in 2020 to 83%). At 18 months, 66% of the patients were alive and the disease did not progress. .The two-year progression-free survival rate and overall survival rate are respectively 61% and 74% .The latest research results to be announced at the ASCO annual meeting in 2021 show that After a median follow-up of 18 months, the overall survival (OS) rate was 81%. The remission rate is comparable in all pre-specified subgroups and patients with different treatment lines.

　　 　

American research shows that cilta-cel has excellent long-term efficacy.　 　

　 　 　 　Emily, a foreign country, successfully ushered in nine years of cancer-free survival in 2021, and suddenly became the "spokesperson" of global CAR-T therapy. In China, there is such a lucky person whose fate has been completely changed by CAR-T therapy. Mr. Min was diagnosed with a special rare disease at the age of 54- multiple myeloma . He had no drugs available at that time, so he was lucky enough to participate in the clinical trial of CAR-T therapy. Although the treatment process was not smooth sailing, after three times of treatment, all the lumps on Mr. Min’s body disappeared and the pain disappeared. Surprisingly, by June 4, 2021, Mr. Min had lived cancer-free for five years, which is the field of cancer treatment, which is theoretically said. Clinical cure .

　 　 　 　In fact, as early as March 27th this year,The FDA approved the first CAR-T therapy targeting BCMA for adult patients with relapsed/refractory multiple myeloma (r/r MM) after receiving more than four therapies.

　 　 　 　Chemotherapy to fight cancer is often "killing one thousand enemies and losing eight hundred". Antibody drugs can accurately find tumor targets, but sometimes their combat effectiveness is insufficient. If we can put a "warhead" of chemotherapy drugs on antibody drugs, can we attack cancer cells more accurately? Based on this, an ADC (antibody drug conjugate) called "biological missile" was born. Antibody-coupled drugs are like biological missiles, which consist of two core functions: the first is antibody (missile body), the second is strong chemotherapy drug (nuclear warhead); This design will enable antibodies to find tumor cells with chemotherapy drugs, and then accurately poison tumor cells and poison them. 　This drug design combines the precision of targeted drugs with the high efficiency of chemotherapy drugs, which not only avoids the toxic and side effects of systemic use of chemotherapy drugs, but also has stronger killing ability than using targeted drugs alone, killing two birds with one stone. 　 　 　 　

Schematic diagram of antibody-coupled drugs 　 Note: (a) General description of A)ADC structure; (b) the mechanism of B)ADC. 　

Fourteen ADC drugs have been approved around the world, which brings hope for prolonging the survival time of back-line patients.

　 　 　 　At present, more than 100 kinds of ADC are undergoing clinical trials. Most adcs have progressed from phase i to phase II. Some ADC phase III trials show positive results; Up to September 20th, 2021, there are 14 kinds of ADC drugs on the market in the world, which are mainly used in hematological tumors and solid tumors, and are mainly used for back-line treatment of patients, including advanced, recurrent/refractory and metastatic tumor indications.

　

Fourteen ADC drugs have been approved worldwide.

According to the curative effect data, ADC drugs have brought more treatment options and the hope of prolonging the survival time for back-line patients, and the objective remission rate or median progression-free survival time of several drugs has doubled compared with chemotherapy.

Looking at the CD30 target, the new drug F0002-ADC became an instant hit and squeezed into the lymphoma track.

　 　 　 　CD30, a member of tumor necrosis factor (TNF) receptor superfamily, can promote cell proliferation or apoptosis by activating different signal pathways. In 2020, Vebtuximab for injection (Adcetris) was approved to be listed in China, and CD30 became famous. Adcetris, as an antibody-coupled drug targeting CD30, has an effective rate of 73% for Hodgkin’s lymphoma (HL) and 86% for anaplastic large cell lymphoma (ALCL). It is the first new drug approved in the field of Hodgkin’s lymphoma treatment in recent 30 years, and it is also the first time that a drug targeting CD30 has been approved, filling the gap in this field. At present, the only new ADC drug for CD30 in China is F0002-ADC. This new drug consists of three parts, namely, human-mouse chimeric anti-CD30 monoclonal antibody, thioether linker (MCC) and DM1. Since the project was launched in 2016, it has been disappointing! At present, patients with recurrent/refractory CD30 positive peripheral T-cell lymphoma are being recruited clinically! This is a new treatment option for patients with recurrent/refractory peripheral T-cell lymphoma!

This article is original for a cancer-free home, and it needs authorization to reprint! Cancer-free homes remind patients