Wen | Fangfang, New Economic Observer Mission

On December 13, 2022, Geely Automobile officially announced that its high-end pure electric brand Extreme Krypton Automobile had secretly submitted the IPO registration documents to the US Securities and Exchange Commission on December 7. At this point, this "traditional new force" established less than two years ago began to break through the IPO.

The data shows that in 2022, a total of nearly 72,000 new cars were delivered, which further narrowed the gap with the new forces’ head camp. However, despite the rapid growth, there are many "problems" in Krypton cars compared with "Wei Xiaoli": performance loss, low gross profit margin, and doubtful high-end positioning are very prominent. Nowadays, the extremely krypton car in the initial stage of development is so eager to go public, is it really hot enough?

01, a rising star, losses.

Compared with other brands of Geely Automobile, the daily performances of Krypton Automobile, which was established in 2021, are showing its more independent existence. But no matter from the development process or business performance, we can’t put it outside Geely Automobile to observe.

Before Krypton Automobile, Geely Automobile had tried many times to transform and upgrade with electrification, but it didn’t splash much water in the new energy market.

In 2015, Geely Automobile released the new energy strategy of "Blue Geely Action" and set an extremely aggressive sales target: by 2020, the sales of new energy vehicles will account for 90% of the total sales. However, at that time, Geely Automobile bet on "oil to electricity", which led to a general market reaction. In 2019, Geely Automobile launched a geometric brand focusing on the field of high-end pure electric vehicles, which is at the same level as Lectra, and the degree of attention can be seen.

But again, the geometric brand has little thunder and rain, and has not broken out its due potential. In 2020, Geely Automobile actually sold 68,000 new energy vehicles (including Geely, Link and Geometry brands), and the proportion of new energy was only 5.15%, far from reaching the target of 90%.

Until March 2021, Geely once again launched the extremely krypton car that positioned the high-end electric vehicle market, while the geometric car returned to the mainstream mass market. Once the former came out, it quickly launched the first mass-produced new car with an average sales price of more than 300,000 yuan, and ran all the way up with the strong support of the group.

Drawing of the delivery table of the new car-making forces in 2022: New Economic Observation Mission

In 2022, Kyk 001 delivered nearly 72,000 new cars, and the average order amount reached 336,000 yuan. Especially in the fourth quarter of 2022, the sales volume of Krypton in January 2001 exceeded 10,000 vehicles for three consecutive months, which was basically able to compete with the head camp of the new forces. It is also the ever-increasing sales of Krypton 001 that makes the capital market begin to re-evaluate the prospective map of Geely Automobile’s new energy.

But the question is, is Geely’s electrification transformation really successful this time? I’m afraid it’s too early to draw a conclusion. Because cars sell well, it doesn’t mean high profitability. At this point, new forces such as "Wei Xiaoli" have already had a deep understanding.

First of all, like "Wei Xiaoli", Krypton cars sell well, but their operating conditions are not satisfactory. Geely Automobile’s interim financial report in 2022 shows that in the first half of 2021 -2022, Kyo Automobile achieved revenue of 2.868 billion yuan and 8.828 billion yuan respectively. However, under the rapid growth of revenue, the net loss is constantly expanding. In the same period, the brand’s net loss reached 1.01 billion yuan and 759 million yuan respectively. In other words, in just one and a half years, Krypton has lost 1.769 billion yuan.

The crazy "burning money" of sub-brands also directly dragged down the overall profitability of Geely Automobile. In the first half of 2021-2022, the net profit of Geely Automobile was 4.847 billion yuan and 1.552 billion yuan respectively, and the year-on-year decline rate of net profit reached 12.4% and 34.81% respectively. As for the reasons for the further expansion of losses, Geely Automobile stated directly in the financial report that the relatively high operating costs of Krypton Automobile in the early stage of development and the confirmation of share-based payment fees in the current period were one of the reasons that adversely affected the profitability of the Group during the period.

It can be said that the climbing road of Krypton automobile is based on Geely automobile’s continuous blood transfusion. Nowadays, extremely krypton cars are eager for IPO. On the one hand, it can be seen that the capital market still shows great tolerance for new forces; On the other hand, it is also the bad situation caused by the group’s long-term blood transfusion behind the crazy burning of money by extremely krypton cars, which is in urgent need of IPO financing.

02, the core indicators are not good, not as good as "Wei Xiaoli"

Geely Automobile’s explanation of the development status of Krypton automobile in the financial report also gave the latter time to change course. However, with the acceleration of the electrification transformation of traditional car companies and the crazy invasion of cross-border people such as Huawei and Xiaomi, the competition faced by extremely-krypton cars is becoming increasingly fierce, and this battle is more filled with strong smoke compared with the increasingly mature head camp of new forces.

Schematic diagram of the comparison of the revenue of the new car-making forces in the first half of 2022 Tabulation: New Economic Observation Mission

First of all, from the volume point of view, the positioning of Krypton 001 has a certain competitive relationship with "Wei Xiaoli" and so on. In recent months, it has broken the sales performance of 10,000 vehicles, posing a great threat to the models such as Weilai ET5 and Tucki P7. However, judging from the volume of both sides, the revenue of extremely-krypton cars still cannot be compared with "Wei Xiaoli". According to the data of various financial reports, in the first half of 2022, Weilai, LI and Xpeng Motors achieved revenues of 20.2 billion yuan, 18.2 billion yuan and 14.8 billion yuan respectively, while the revenue of Krypton Automobile was only 8.8 billion yuan.

Graphic tabulation of gross profit margin of the new force of making cars in the first half of 2022: new economic observation group

At the same time, judging from the gross profit margin of various companies, there is a big gap between the profitability of extremely krypton cars and the head camp of new forces. According to An Conghui, CEO of Krypton Automobile, in the first half of 2022, the gross profit margin of Krypton automobile was around 5%. In the same period, the gross profit margins of LI, Weilai and Xpeng Motors reached 22.09%, 13.8% and 11.55% respectively.

The more serious situation is that Li Xiang, the founder of LI, revealed that the company is about to reach the turning point of breakeven. Li Bin, the founder of Weilai, also said that it is expected to break even in the fourth quarter of 2023. Obviously, the first batch of new car-making forces have touched the threshold of performance and profitability, while extremely krypton cars are still struggling in the whirlpool of losses.

Despite the poor performance, the capital market’s evaluation of extremely krypton cars is not low. In August, 2021, Krypton Auto completed the Pre-A round of strategic financing of US$ 500 million (equivalent to RMB 3.24 billion), with five ecological partners including Intel Capital and Contemporary Amperex Technology Co., Limited participating. After the completion of the investment, five companies got 5.6% of the shares of Extreme Krypton Automobile, and Geely Automobile’s shareholding dropped to 48%, but it is still the single largest shareholder of Extreme Krypton Automobile. At that time, the valuation of Krypton cars had reached $9 billion.

According to informed sources, this IPO in the United States will seek a valuation of more than 10 billion US dollars, and it is planned to be listed in new york as early as the second quarter of 2023. The reason why we abandoned the HKEx and chose new york as the listing place is to seek a higher valuation.

Looking at the new force "predecessors" car companies, "Wei Xiaoli" has taken the lead in listing in the United States. It took four years, six years and five years for the three companies to go public. If Krypton can really successfully pass the IPO within the predicted time, it means creating a record of the shortest time to market for new forces. And its valuation of nearly 70 billion yuan, although there is still a certain gap with Weilai (134 billion yuan) and Ideal (156.7 billion yuan), has surpassed the current market value of 57.6 billion yuan in Xpeng Motors and the zero-running car listed in September last year (the market value as of January 13 was 26.7 billion yuan).

It can be seen that although the performance is not satisfactory, the capital market still has high hopes for extremely krypton cars. However, there is a lesson that the stock price of the zero-run car broke and fell by more than 33% on the first day of listing. It is still unknown whether the extremely-krypton car can re-sample for the listing of new forces.

03, "Benchmarking Tesla", the road to high-end is not easy.

In addition to the embarrassing status quo, the problem of the extreme krypton car is that "ambition is not worthy of ability." From the emphatic wording of "the average order amount exceeds 336,000 yuan" in the sales posters of each issue, we can see that it is imperative for extreme krypton cars to hit the high end. After all, according to the definition of "high-end models" by the Federation, the starting price of products must exceed 300,000 yuan.

However, in the upsurge of "benchmarking Tesla" on the Internet, Extreme Krypton 001 played a configuration beyond Tesla such as "712km long battery life", hoping to raise the product positioning. However, in Tesla’s repeated price reduction boom, Krypton has lost its vital price advantage. As for the level of revenue and profitability, the two are not an order of magnitude.

One of the most critical problems that hinder krypton cars from taking the high-end road is that product problems emerge one after another.

Extreme krypton cars rank first in complaints. Image source: Car Quality Network

On January 1, 2023, Extreme Krypton Automobile announced that the new Extreme Krypton 001 was officially launched, and the new car was fully upgraded at the configuration level. However, it failed to take into account the rights and interests of old car owners. Since January 2nd, there have been hundreds of complaints about "sales promise not fulfilled" in the online complaint platform, ranking first in the complaint list.

According to the old owner of Krypton 001, after the launch of the new model of 001, the "old" owners who decided in advance have received the "overlord clause" to cancel the lifetime warranty, and the related rights and interests have also shrunk. The car owners accused the car of "cutting leeks" and did not hesitate to make false marketing to harm the legitimate rights and interests of consumers.

In addition, some car owners revealed that in addition to the change of rights and interests, the car also unilaterally locked the order automatically, which was inconsistent with the information promised at the beginning, and today’s terms are even more unreasonable. As of press time, Extreme Krypton Automobile has not announced the handling results of this incident.

Complaints against extremely krypton cars (partial) Image source: Car Quality Network

The actual situation is that there is a precedent for the "false marketing" of extremely krypton cars. On New Year’s Day last year, Extreme Krypton Automobile released the rights and interests of the Spring Festival, which led to the price of new cars under the same configuration being lower than the purchase price years ago, which triggered the rights protection of old car owners. After several rounds of games, Krypton finally reached a settlement with the old car owners in the form of "returning 5,000 yuan".

Since then, Krypton 001 has also experienced various questions and problems such as "disguised price increase", "replacement of motor", "EC light-sensing canopy goods are not on the right board" and "order delay". More importantly, after the incident, the authorities never paid enough attention to the owner of the extremely krypton car. Instead, they responded indifferently by destroying misleading legends and perfunctory apologies, which made the owner even more annoyed.

As we all know, one of the biggest differences between new forces and traditional car companies is that they are good at user marketing and often play the banner of "deeply linking users" in order to win the favor of more consumers. However, judging from the company’s performance, although it classifies itself as a new force, it still has the "arrogance and prejudice" of traditional car companies in its bones. This simple and rude response has had a negative impact on the brand image.

On January 9th of this year, the second new car, Extreme Krypton 009, was officially mass-produced, and it is expected to be officially delivered in the second half of January. The new car hit the "high-end" goal again, and the prices of the two models were 499,000 yuan and 588,000 yuan respectively.

However, even Jason Lin, vice president of Extreme Smart Technology, once said, "To meet the high end, it is not how much money is used to measure the high end, but whether you can represent the most important products in that market." No matter from the perspective of copying the bottom chip of Krypton 001 completely or the battery scheme that has not been optimized and upgraded, it is obvious that Krypton 009 has not controlled the core technology well.

To add insult to injury, the problem of false propaganda of Qianqiu Kyo 001 has not been properly solved, and Kyo 009 was controversial because of the advertisement "All pets are love" on the day of listing, and finally ended up deleting the advertisement. Prior to this, Li Xiang also questioned the interior space of the extremely krypton 009 and "poured cold water" on the listing of the new car. Nowadays, Krypton 009 has not been mass-produced and delivered, and it has suffered from public opinion crises one after another. This is really not a good sign.

For a company to be listed, the establishment time is too short, the loss situation of the company is increasing, and the product quality problems have been repeatedly criticized, which will become a stumbling block on the road to sprint IPO. Whether Geely can achieve the goal of high-end by relying on Krypton 009 can be successfully achieved, I am afraid it will take a long time to investigate.

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Text | "China Entrepreneur" reporter Mo Wei

Editor | Maggie Ying

"Wen Jie will be the first mainstream brand to fall down this year." Adi (pseudonym) sighed. Adi is one of the first brands to sell in the world. He worked in a luxury car brand for many years and joined the world two years ago with the word "Huawei". But at the end of February, he chose to leave.

At present, this conclusion is premature and somewhat absolute. However, from the public data, compared with the sales performance in January and February this year, the industry has not yet stepped out of the sales trough. According to the sales report issued by Cyrus, in March, the sales volume of the industry was 3,679 vehicles, which was significantly lower than the monthly sales volume of over 10,000 vehicles last year. Within the realm of question, greater changes have also taken place.

On the morning of March 31, an announcement of "Resolution on Huawei Not Building Cars" inside Huawei was circulated on the Internet. According to the news, the resolution was issued by Ren Zhengfei, the founder of Huawei, and once again stressed that Huawei does not build cars and is valid for 5 years. Ren Zhengfei specifically emphasized that Huawei /HUAWEI could not be used in vehicle publicity and appearance.

On the afternoon of the same day, at the press conference of Huawei’s 2022 annual report, Xu Zhijun, vice chairman and rotating chairman of Huawei, once again stressed: "Some departments, individuals or partners are abusing Huawei’s brand. In the process of investigating this matter, the brand built by Huawei for more than 30 years will not be abused by anyone. Huawei doesn’t make cars, and it doesn’t have any brands of cars. Huawei brand is strictly prohibited as an automobile brand. We will rectify internal promotional materials such as flagship stores and return to strategy. "

Then, it was reported publicly that Yu Chengdong, managing director of HUAWEI, CEO of BG and CEO of BU, a smart car solution, ordered that the removal of Celestial cars in Huawei stores involved all promotional materials of Huawei brand, especially the sinking market.

On April 3, in a Huawei experience store in a shopping mall in the suburbs of Tianjin, the words "Huawei asks the world" have disappeared from the publicity screen in the store, and the display boards at the license plates before and after the show have been replaced with "AITO". The pasting of the new license plate is obviously a little hasty, the rear license plate is a little distorted, and the double-sided tape used for pasting is even exposed.

Photography: Mo Wei

Although there is no written logo of "HUAWEI asks the world" in the store, Huawei asks the world is still on the lips of store sales. When adding the WeChat of the in-store sales consultant, the nickname prefix suddenly shows "HUAWEI asks the world".

"Golden signboard" is not enough.

Summarizing the work experience in the field of inquiry in the past two years, Adi’s answer is: love is the deepest responsibility.

The reason why he thinks that the world of inquiry will "fall down" this year is not for his old club’s downfall, but for the future fate of the world of inquiry after "clearing the relationship" with Huawei.

In Adi’s impression, at the beginning of the establishment of the world, the manufacturer Cyrus has always been a humble existence. "The marketing and quality inspection of the brand are all led by Huawei, and even in the training courseware sold, Cyrus is not mentioned." Although he joined the brand in the world, all his work and performance are managed by Huawei. "Huawei will send a Huawei person to supervise in every store that sells cars, responsible for managing and conveying some guidelines from manufacturers and activity plans."

Adi’s feeling is that Huawei has always been a very strong presence, and the people who were stationed in the store at the beginning are very capable, which can help the sales people to make orders and sell better. "It sold very well at first, with an average of about three transactions a month. At that time, Huawei also wanted to make Cyrus a benchmark to prove its strength. "

Chen Jie (a pseudonym), another sales consultant who switched to Japanese brands from the world of inquiry, also has a deep understanding of Huawei’s strength. In the sales process, Huawei’s leading role is obvious. In 2022, it achieved a sales volume of 75,000 vehicles throughout the year, and was called "the fastest growing brand of new energy vehicles".

However, in the beginning of 2023, the price war in the automobile market intensified, and the sales volume in the world continued to decline. In 2023, the sales volume in January was 4,885 vehicles, down 56% from the previous month. In February, the sales volume dropped to 3,505 vehicles, down 21% from the previous month.

The pressure on the sales side has increased significantly. Since the beginning of this year, Adi obviously feels that Huawei is in a mess. "The preferential policies promoted by Huawei are said to be the lowest in history every time, and then it won’t be long before the activities are held again, and the price is even stronger than before."

After several times, Adi had no idea when communicating with customers, and could not confirm the preferential amount. "Internal policies are often inconsistent."

What makes Adi even more helpless is Huawei’s "involution" at the dealer level. "There are a lot of stores in a city, and each store recruits a lot of people. These stores are not the same boss, and the price is very serious." Adi said that in order to sell cars, peers kept each other’s prices down and even let their profits go.

Later, the professionalism of Huawei’s staff stationed in the store was also greatly reduced. "They don’t even understand Huawei’s basic policies."

At the same time, Huawei will have requirements for data such as test drive in the store, and most of this data can’t be completed. "There are many stores and many salespeople. In order to complete the task, the store will share it. Let’s find relatives and friends to complete it." For a long time, Adi and his colleagues were tired of completing the test drive data task in the store.

In this case, the loss of intentional customers has become the biggest problem. A lot of sales around Adi have lost many intentional customers because of the changeable prices and various "coquettish operations" in the store.

Due to the failure to complete the work task, the performance salary was deducted, and some sales people chose to leave their jobs. Artie is one of them.

A partner who starts a new stove

Although he has left, Adi is still paying attention to the world.

Adi and his former colleagues have discussed a lot about "drawing a clear line" between Huawei and the media. In their view, Huawei is somewhat "throwing a pot" in the case of poor overall sales at this time.

In the inner voice community of Huawei, Ren Zhengfei signed a post saying "Huawei doesn’t make cars", and Yu Chengdong left a message: "This era has changed, which will only make it more difficult for us! After a few years, everyone will understand! Leave time to test! " "For an industry, only in-depth insight and deep understanding can we grasp the correct direction! Mark it and come back in a few years! "

Since Huawei set foot in the automobile business in 2019, Yu Chengdong has been labeled as a "car maker". In February this year, the news that Wang Jun, the original Huawei smart car solution BU COO, was suspended came out, and the news that Yu Chengdong was fully responsible for BU was rampant. Immediately, photos of Yu Chengdong’s visits to Sellers and Aouita came out.

It seems that Huawei’s car-making route has become as radical and bold as himself.

At the beginning of March, "HUAWEI asked the world" appeared in the holiday poster released by HUAWEI terminal. Among the official accounts of the car, "AITO asked the world" was quietly replaced by "Huawei asked the world".

Promotional materials in offline stores are also updated synchronously. In the sinking market, the words "Huawei Auto" even appeared.

On March 30th, the day before Huawei and Cyrus "drew a clear line". Celestial’s company launched a brand-new new energy vehicle brand Blue Power, equipped with BYD Foday hybrid system. Sailis said that this is a brand new brand that is different from the outside world.

This is also regarded by the outside world as a signal that Cyrus is "planning ahead" and starting a new stove.

The change of HI mode partners is more obvious. It is reported that a senior executive of BAIC Polar Fox expressed his dissatisfaction with Huawei at a recent internal meeting. "We have cooperated with Huawei for so many years, and Huawei has gained a lot of voice. What have we got?" Under the bleak sales of Alpha created in cooperation with Huawei, BAIC has begun to promote the mother-baby parent-child model "Koala".

Another partner, GAC, has also undergone new changes. On March 27th, Guangzhou Automobile Group said that the AH8 project jointly built by Guangzhou Automobile Ai ‘an and Huawei was changed to independent development, and Huawei will participate as an important supplier. This means that the HI mode of GAC and Ai ‘an has fallen through.

In the public interview, Feng Xingya, general manager of Guangzhou Automobile Group, talked about the cooperation with Huawei and bluntly said that Guangzhou Automobile needs more brand characteristics. This just corresponds to the "soul theory" put forward by Chen Hong, the chairman of SAIC.

On April 1st, when Yu Chengdong attended the committee of 100 Forum on Electric Vehicles in China (2023), he said that Huawei was still under sanctions, and its partners were limited. "The new forces have their own intelligent pursuit, and it is unlikely to cooperate with us. It is also difficult for European, American and Japanese companies to choose Huawei. In the end, only traditional car companies are left." Yu Chengdong said.

An engineer from a head parts supplier told China Entrepreneur that Huawei seems to have neglected the brand dignity that traditional car companies value most, and planned a lot of cooperative car companies and models, which eventually became a constraint.

On April 6, the related content of "HUAWEI asks the world" has not been deleted from Huawei’s official accounts such as Huawei Terminal.

Huawei to ensure survival

Yu Chengdong insists that the cooperation has not changed. However, in the rapidly changing China market, it is becoming more and more difficult to do both the brand and Huawei’s automobile business.

In an interview with China Entrepreneur, Zhang Yun, global CEO of Rees Strategic Positioning Consulting and chairman of China, said that Huawei’s insistence on not building cars is a comprehensive choice.

"Huawei’s mobile phone business has been affected in the United States. If the car moves the’ cheese’ of European and American companies again, it will be’ killed’ in overseas core markets." Zhang Yun said that this is a statement spread from within Huawei and also reflects Huawei’s overall strategic considerations.

"If Huawei is a core supplier of smart cars, the technical value of core components is very high, and its value may be higher than that of a car-making enterprise." Zhang Yun believes that from the perspective of business value, technology is not only an area that Huawei is good at, but also can create more value.

In Zhang Yun’s view, just because Huawei can make a good mobile phone does not mean that it can also make a good car. "It takes a lot longer to make a car than a mobile phone. Interlacing is like a mountain. " This view seems to confirm the choice of Ren Zhengfei, the founder of Huawei.

According to the financial report data released by Huawei on March 31st, in 2022, the company’s net profit decreased by 68.7% year-on-year, and the cash flow from operating activities decreased by 70.2% year-on-year. Although Meng Wanzhou, the rotating chairman, has repeatedly stressed that Huawei’s cash flow is still sufficient, the declining data has already reflected Huawei’s survival status in the current market environment.

As early as last year, Ren Zhengfei published the famous "Cold Theory" based on the changes in the domestic and international market environment, saying that Huawei should take survival as the highest program, focus on strategy and burn less money.

The impact of the car-making business seems to be contrary to Ren Zhengfei’s strategy.

The data shows that Huawei BU is the only loss-making business unit. China Entrepreneur learned from Huawei officials that BU, a Huawei smart car solution, has invested 3 billion US dollars in R&D since its establishment, with as many as 7,000 R&D personnel.

In the 2022 annual report, Huawei’s sales revenue in carrier business, enterprise business and terminal business was 284 billion yuan, 133.2 billion yuan and 214.5 billion yuan respectively. Among them, the revenue of smart car solution parts business was 2.1 billion yuan.

From the perspective of Huawei’s overall business, after the terminal mobile phone business encounters sanctions, Huawei may not be able to bear the car business to get into trouble again. The first task is to ensure the safety and survival of its main business.

Many people in the industry also believe that whether from the basic logic of building a car or the increasingly fierce market competition, Huawei should really be more rational in building a car.

In his speech at the committee of 100 Forum, Yu Chengdong said: "In the past, Huawei leaders, including Ren Zong, wanted to become a Tier1 supplier similar to Bosch, but now the conditions of this strategy seem to be untenable."

References:

Yu Chengdong ordered overnight: Remove Huawei logo! The latest response, Global Times

Ren Zhengfei "strangles" Huawei to build a car, and Yu Chengdong mourns! ",Electric Vehicle Commune

"The board hits Yu Chengdong, and Ren Zhengfei hurts", Snow Leopard Finance and Economics.

Editor on duty: Wang Yijie Review: Zhang Gege Production: Wu Ying

Transfer from: China Business Network.

Our reporter Yin Limei Tong Haihua reports from Beijing.

(601633.SH) In September this year, it sold 121,600 new cars, a year-on-year increase of 29.89%. From January to September this year, it sold a total of 864,000 new cars. On the evening of October 8, Great Wall Motor disclosed the above data.

"China Business News" reporter noted that the sales volume of Great Wall Motor in the first three quarters of 2023 "jumped three times in a row", achieving a step-by-step growth. In the first quarter, Great Wall Motor sold 220,000 vehicles; In the second quarter, the sales volume was 299,300 vehicles, an increase of 36.05% from the previous quarter; In the third quarter, the sales volume reached 344,800 vehicles, an increase of 15.22% from the previous quarter.

New energy vehicles play an increasingly important role in the annual sales of car companies. In the first three quarters of this year, Great Wall Motor sold a total of 170,300 new energy vehicles, a year-on-year increase of 75.77%; In the first, second and third quarters, the sales of new energy vehicles accounted for 12.64%, 21.86% and 22.37% respectively, showing a trend of increasing quarter by quarter. This shows that the long-term strategic achievements of Great Wall Motor have begun to appear.

Previously, Feng Mu, president of Great Wall Motor, told reporters that new energy vehicles have reached a critical juncture, and the bloodletting price war is definitely not a long-term solution. Only by persisting in long-term doctrine and making the system have the ability to make blood, can enterprises go further.

The reporter also noted that thanks to the intelligent new energy development strategy, the pace of Great Wall Motor’s overseas ecological going to sea has accelerated, and at the same time, high-end models have continued to grow, and Great Wall Motor’s product matrix has formed a structural high-quality development. From January to September, the total export volume of Great Wall Motor reached 211,700 vehicles, up 89.45% year-on-year; The sales volume of vehicles above 150,000 yuan reached 179,700 vehicles, up 98.49% year-on-year, and the brand continued to improve. In the first, second and third quarters, the overseas sales of Great Wall Motor accounted for 23.63%, 24.04% and 25.45% respectively, and the proportion continued to grow.

It can be seen that with the adjustment and upgrading of product structure, star models have been listed one after another, the sales channel network has been accelerated, and the global layout has been deepened. Great Wall Motor has pressed the development acceleration button.

In the third quarter, the top five brands were "all red"

Specifically, the Haval brand sold 73,800 vehicles in September, a year-on-year increase of 37%; Under the strategic blessing of intelligent new energy, Haval sold 203,300 new cars in the third quarter, an increase of 22% from the previous quarter. In the third quarter, the Haval brand launched its efforts in the off-road field, and successively released 2024 Haval Big Dogs and the new Haval H5, a large-scale all-purpose hard-core SUV. The Haval Raptors, a new energy off-road popularization, will also be listed on October 10, leading the new energy off-road SUV to enter the era of the whole people.

Weipai New Energy sold 14,800 vehicles in the third quarter. Since the launch of the six-seat comfortable electric SUV Blue Mountain DHT-PHEV, the popularity has continued to rise, with a cumulative sales volume of more than 24,000 vehicles. During the Chengdu Auto Show, Wei Gaoshan DHT-PHEV officially opened the reservation and will be listed in the near future. In terms of terminal ecology, Weipai currently has 285 terminal stores, including 167 brand-new image stores, and has accelerated the construction of a multi-level sales service network including 4S stores, city exhibition halls and supermarkets, and continuously deepened the pace of high-end development of Weipai.

The Euler brand sold 10,000 vehicles in September, up 31.77% year-on-year, and sold over 10,000 vehicles for five consecutive months, leading the way in the new energy women-friendly subdivision track. In the third quarter, the Euler brand ushered in 400,000 off-line vehicles, officially becoming the first female new energy vehicle brand in the world to break through 400,000 vehicles. In the third quarter, the Euler brand also released the 2023 Euler Ballet Cat, the 2023 Good Cat and the Good Cat GT Mulan Edition, creating a better travel experience for users with the continuous renewal of product quality and service ecology.

Tank brands sold a total of 18,000 vehicles in September, a year-on-year increase of 43.15%. With the blessing of medium and large luxury off-road new energy SUV tank 500 Hi4-T and 2024 tank 300, the tank sold 104,500 vehicles from January to September, up 17.22% year-on-year. At the same time, the tank brand achieved sales of 300,000 vehicles in only 33 months, setting a record for China off-road brands to achieve sales of 300,000 vehicles at the fastest time, ranking first in the sales list of off-road SUVs in China market. In addition, the second model based on the Hi4-T architecture, the medium and large-scale urban function off-road SUV tank 400 Hi4-T, was launched on September 25th to meet the needs of users for urban and off-road vehicles.

Great Wall pickup trucks sold 17,200 vehicles in September, and accumulated sales of 152,700 vehicles from January to September, up 6.5% year-on-year. From January to September, the domestic market share of the Great Wall pickup truck was close to 50%. For every two pickup trucks sold in China, one was the Great Wall pickup truck. Great Wall Gun sold 12,200 vehicles in September, with a cumulative sales volume of over 10,000 vehicles in 37 months, ranking first in pickup truck sales in China. In the third quarter, on the occasion of the fourth anniversary of the Great Wall Gun brand, the 500,000th vehicle was officially rolled off the assembly line, becoming the first high-end pickup truck brand in China to break through 500,000 vehicles, creating a new "Great Wall Gun Speed". Shanhai Gun Performance Edition, a large-scale high-performance luxury pickup truck owned by Great Wall Gun, will be pre-sold nationwide in mid-October after welcoming the world’s first show at Chengdu Auto Show.

The reporter is concerned that with the continuous efforts in the intelligent new energy track, the terminal channels of Great Wall Motor have developed rapidly, and its new energy terminals have reached 156 in August, and it is expected to grow to 1,200 during the year. The three major measures of matrix rejuvenation, channel expansion and service upgrade have worked together, and Great Wall Motor’s intelligent new energy has entered a period of rapid development.

Globalization has entered the era of "One Great Wall"

Overseas business is becoming an important part of car companies’ sales business. In the third quarter, Great Wall Motor sold 87,800 vehicles overseas, an increase of 21.97% from the previous month, accounting for 25.45% of the sales volume. From January to September, Great Wall Motor sold 211,700 vehicles overseas, up 89.45% year-on-year.

"While the sales volume of Great Wall Motor has steadily increased, it has focused on ‘(ONE GWM’ and implemented the strategy of’ Eco-going to Sea’ to achieve accelerated development overseas." Great Wall Motor said.

At the end of 2022, Great Wall Motor officially announced the "ONE GWM" global action plan, creating an aggregation channel with GWM parent brand as the leading category, and working together to achieve brand promotion. At this stage, the localization operation of Great Wall Motor overseas will pay more attention to the improvement of "quality", deepen the connotation of "ecological going out to sea" and create brand advantages.

It is reported that in the third quarter of 2023, Great Wall Motor accelerated the expansion of the international influence of the "GWM" brand. In August, Great Wall Motor successively released the "GWM" brand in Vietnam and Indonesia, realizing the comprehensive coverage of the core regional markets of ASEAN countries. In Latin America, the launch conference of GWM brand of Great Wall Motor and Haval H6 HEV was held in Mexico City, Mexico, marking the official entry of Great Wall Motor into the Mexican market.

In the era of "One Great Wall", Great Wall Motor adheres to the core of "intelligent new energy", and intelligent new energy technologies and products have become the key factors to promote the acceleration of going to sea.

The reporter learned that the five brands of Great Wall Motor have all gone to sea, and high-value intelligent new energy products such as Haval H6 New Energy, Tank 500 New Energy, Euler Good Cat and Wei Mocha PHEV are being accelerated to be put into overseas markets. Advanced new energy and intelligent technologies, such as Hi4, Hi4-T, autonomous driving and intelligent cockpit, will continue to make technical endorsements for the global models of Great Wall Motor.

It is reported that Haval H6, Haval JOLION, Haval Big Dog, Euler Good Cat, Tank 300, Great Wall Gun and other models have been listed in Cambodia, Vietnam, Brazil and other places.

At the same time, Great Wall Motor is also exporting high-end products to overseas markets. The Great Wall Motor Tank 500 has been listed in the Middle East market in succession in the United Arab Emirates, Saudi Arabia, Oman and Bahrain. In addition, in Central Asia, the listing of Tank 500 was held in Almaty, the largest city in Kazakhstan. In the ASEAN market, Tanks 300 and 500 are officially listed in Thailand.

Great Wall Motor’s vision is not only to launch products to overseas markets, but to practice the strategy of "going out to sea ecologically" and take root in overseas localization operations. Great Wall Motor has taken production and R&D abroad through the investment in overseas factories, improved the training and accumulation of local talents, and formed an all-round construction of overseas ecological and industrial chain.

At present, Great Wall Motor has formally signed a strategic cooperation agreement with ADM Automobile Factory of Uzbekistan Automobile Group on Uzbekistan’s market development cooperation, further accelerating the process of overseas localized production and sales of Great Wall Motor.

"In the future, with the outstanding achievements of Great Wall Motor’s intelligent new energy layout, Great Wall Motor will continue to accelerate the rejuvenation of intelligent new energy products with profound technical accumulation, continuously enhance the development potential of intelligent new energy, promote the upgrading of terminal services, accelerate the landing of the’ ecological sea-going’ model overseas, and push the development of enterprises to a new height." Great Wall Motor said.

(Editor: Zhang Shuo Proofreading: Yan Jingning)

　　Because of its sports, fun and fashion, in recent years, emerging amusement projects such as rock climbing, trampoline, bridge swinging, equestrian and bungee jumping are popular among young people and even children, but their safety risks cannot be ignored. On August 31st, in order to promote the health of the emerging amusement industry, Beijing Shunyi Court made a summary of the legal risks reflected in the disputes involving emerging amusement projects, and made suggestions to consumers, operators and relevant departments.

　　Typical case

　　Injury while playing trampoline was not treated in time.

　　Be diagnosed with grade 10 disability

　　A total of five people from Yan and his friends went to play in a trampoline park run by an ecological farm in Beijing. Before entering, Zou and others signed the "Notice of Exemption for Admission Safety".

　　Yan said that it was his first time to play trampoline on the day of the incident. When he entered the venue, no staff told him which areas were advanced and which areas were primary. During the playing process, no staff gave him guidance. He was injured while doing somersault in the white area, and then he did not report his discomfort to the staff. The staff did not give him first aid or take corresponding medical measures. He did not go to the hospital in time because he did not expect to be so seriously injured at that time. Finally, the hospital diagnosed it as a burst fracture of thoracic vertebra 12 and a spinous process fracture of thoracic vertebra 11. After identification, Zou constituted a level 10 disability.

　　In the end, the court found that Yan was responsible for 80%, and the operator was responsible for 20%, and compensated Yan for personal injury losses of more than 60,000 yuan.

　　Coincidentally, when Ms. Xu, a citizen of Beijing, was playing on the Huangqiao Bridge in online celebrity, a water park in Shunyi, Beijing, many tourists accidentally fell into the water, and the pool was too shallow and lacked protective measures, which caused her calcaneal fracture, which was a grade 10 disability. Ms. Xu sued a company that managed it. On July 21 this year, Beijing Shunyi Court ordered a company to compensate Ms. Xu for medical expenses, nursing expenses, lost time and mental damages totaling 175,385.55 yuan.

　　In this regard, Liu Hongyan, president of Niulanshan Court of Shunyi Court, said that most of the emerging amusement projects have evolved from professional sports and there are great security risks. Liu Hong Yan said that due to reasons such as low industry entry threshold, inadequate safety tips, and insufficient personnel and equipment protection, safety incidents caused by emerging amusement projects frequently occur, and such disputes are also on the rise year by year. In 2019 alone, Beijing courts accepted 67 such cases.

　　"It is worth noting that the injuries of the injured in such cases are mostly serious, and the rate of identification as disability is large, which has caused heavy trauma to both the injured and the operators."

　　Risk warning

　　Emerging amusement projects have low barriers to entry.

　　Lack of industry standards

　　At present, places such as trampoline hall, rock climbing hall, partying hall and water park, which are engaged in new amusement projects, are not professional sports venues, and the state has no specific qualification requirements for their operators, and there are also no unified standards and requirements for their market access conditions, venue specifications, amusement facilities, staffing and management level. Operators only need to obtain industrial and commercial business licenses to operate.

　　In addition, the key hardware facilities and safety equipment in the business premises, such as the location requirements, instructions for use, the number of people and the weight of climbing ropes, lack clear specifications and standards, and most of them are purchased or built by operators themselves, and there is no need to go through relevant inspections before they are put into operation.

　　The rules of the game are unclear and the industry supervision is absent. Whether trampoline and other emerging sports have relatively uniform rules and action standards is not fully understood by the general public and players, and the relevant industry departments have not formulated and popularized the rules and precautions of this kind of amusement projects, especially for the players’ own physical requirements, the formulation of rules and the maintenance of game order.

　　In addition, there is also a lack of corresponding supervision over the operators and business premises that operate the above amusement projects. Whether the first-aid drugs, first-aid personnel and measures in the business premises are fully prepared, and whether there are corresponding penalties for operators who have safety accidents, etc., there is still a lack of industry guidance and supervision for emerging amusement projects.

　　Insufficient safety tips in business premises and abuse of exemption clauses. Before tourists enter the business site and prepare to play, most operators do not fulfill their full obligation to inform and prompt, so that players can fully understand the safety risks of the projects they want to play, and then make correct choices and decisions based on their own physical fitness.

　　Uneven staffing and lack of safety guidance. Although emerging amusement projects belong to amusement projects, they are professional and dangerous. However, some operators are not equipped with professionals to save costs, so players can’t ask for help in time when they encounter problems.

　　Consumers’ lack of risk awareness and violation of safety tips. Some consumers do not know enough about the risks that emerging amusement projects may bring, blindly pursue excitement, and imitate difficult movements without professional training and guidance. In addition, some consumers lack sufficient experience and skills to deal with emergencies, and often panic and mishandle them.

　　The judge suggested

　　Consumers carefully and rationally choose play items.

　　Regulatory authorities improve industry norms

　　In view of the above risks, Tu Lin, a judge of Niulanshan Court of Shunyi Court, made corresponding suggestions to the players, operators and relevant departments.

　　Players improve their awareness of risk prevention and choose their play items carefully and rationally. Taking into account the existence of normal risk factors in sports activities, Article 1176 of the Civil Code promulgated this year stipulates that "the victim may not ask other participants to bear tort liability if they voluntarily participate in cultural and sports activities with certain risks and are damaged by the actions of other participants; However, unless other participants have intentional or gross negligence in the occurrence of damage. " Based on the risk-taking principle, the following suggestions are put forward for players:

　　First, read the risk notice carefully and choose the play items carefully. The second is to follow the rules of the game and never challenge high-risk actions. The third is to seek medical advice in time after the injury and keep the evidence properly.

　　The regulatory authorities improve industry norms and strictly supervise and manage.

　　First, improve the industry norms and standards of emerging amusement projects, strengthen the qualification review of business entities and employees, formulate production and installation standards for equipment and facilities of high-risk amusement projects, and introduce basic game rules and prohibitions of corresponding amusement projects. The second is to strengthen the law enforcement supervision of industry operators. It is necessary to intensify the investigation and punishment of illegal acts, refine the safety operation standards, strengthen the implementation of standards, increase the administrative management and supervision of the implementation of safety responsibilities of operators, and improve the standard level of workplace safety management. The third is to improve the relief channels. Open telephone complaints, online complaints and other channels for the misconduct of operators, and punish them once they are verified.

　　Text/reporter Song Xia

　　Source: southern window.

　　"There is a new Great Wall in the north and BYD in the south." At the new car launch in 2022, Li Ruifeng, CGO of the Great Wall, still described the relationship between his family and his friends and businessmen as "North Qiao Feng, South Murong", just like appreciate each other between heroes.

　　But it didn’t arrive in a year, and North Qiao Feng gave South Murong a sneak attack.

　　On the morning of May 25th, Great Wall Motor issued a statement saying that it had submitted materials to the Ministry of Ecology and Environment, the State Administration of Markets, and the Ministry of Industry and Information Technology, and reported that BYD Qin PLUS DM-i and Song PLUS DM-i used atmospheric fuel tanks, which were suspected of failing to meet the emission standards of evaporative pollutants from the whole vehicle.

　　A few hours later, BYD made a statement saying that it resolutely opposed any form of unfair competition and reserved the right to legal proceedings. BYD said that the test vehicle submitted by Great Wall did not meet the requirements of the national standard, and that its test report was invalid.

　　One is the abdicated crown, and the other is the popular new king. The Great Wall’s tip-off letter to BYD, like a hero’s post widely distributed all over the world, made the auto market, which was already in dispute with blood and rain, stir up waves again.

　　Report what?

　　If you want to understand this matter deeply, you need to first interpret the core of the Great Wall report letter, that is, the problem that "the atmospheric oil tank is suspected of causing the evaporation pollutant discharge to fail to meet the standard".

　　Generally speaking, ordinary cars can use an atmospheric fuel tank. The fuel in the atmospheric fuel tank is controlled by atmospheric pressure and can be delivered to the engine by gravity or fuel pump.

　　This kind of oil tank is generally made of plastic and designed to work at atmospheric pressure. The internal and external environment are kept at the same pressure, and the positive pressure is 4~7Kpa.

　　However, for some hybrid vehicles, high-pressure fuel tanks are needed for the sake of emission standards.

　　Because compared with fuel vehicles, the engine of hybrid vehicles is not used frequently, and gasoline is very volatile. If it is not used often, it will accumulate a lot of oil and gas over time and easily escape.

　　Don’t underestimate these vaporized gasoline. The data show that fuel evaporation emissions account for about 20% of light vehicle emissions, which is one of the important sources of air pollution. The "National Six" emission standard has strict requirements on the fuel evaporation control system of automobiles, which makes hybrid vehicles need to solve this problem.

　　As a result, the high-pressure fuel tank came into being. In the high-pressure fuel tank which can bear pressure of 35~40Kpa, oil and gas will remain in the fuel tank under high pressure, and will enter the manifold through the carbon canister when the engine is running, thus reducing the emission of fuel evaporation.

　　BYD Qin PLUS DM-i and Song PLUS DM-i belong to hybrid vehicles. Facing the emission demand, high-pressure fuel tanks may be needed to prevent oil and gas from escaping.

　　After explaining the reporting point, let’s see if it is possible for BYD to use the atmospheric fuel tank.

　　According to common sense, Great Wall Motor obviously has some evidence in its hands when it reports with such fanfare. In BYD’s response, it did not deny the use of atmospheric fuel tanks, explaining that the mileage of the test vehicles that focused on the Great Wall was insufficient, and it was the point that the test report was invalid.

　　Due to the requirements of high-pressure fuel tanks for pressure resistance, the materials of such fuel tanks are mostly steel fuel tanks or encrypted plastics, and the matching fuel cap, fuel filling pipeline and evaporation pipeline also need to be specially made, and the cost is higher than that of atmospheric fuel tanks.

　　From the point of cost reduction, BYD does have the motivation to use atmospheric fuel tanks.

　　However, the hybrid vehicle using atmospheric fuel tank does not necessarily fail to meet the standard of fuel evaporative emission, which needs further testing and verification by relevant departments.

　　The reason why BYD played "3,000 kilometers" actually has a saying.

　　Qin PLUS DM-i and Song PLUS DM-i, as plug-in hybrid cars, have versions with a battery life of more than 100 kilometers. If you only run the "450-670 km" in BYD’s response, there is a high probability that a box of oil has not been run.

　　If a tank of oil is not run out, the frequency of natural internal combustion engine is not high. If it is left standing for a period of time and not kept and sent for inspection within the specified time, the test results may be biased and cannot objectively reflect the emission values of vehicles.

　　Therefore, just looking at the first round of confrontation, the Great Wall only hammered BYD’s "atmospheric fuel tank", but it was temporarily unable to hammer BYD’s emissions.

　　Why today?

　　There is an interesting detail in the tip-off. Great Wall reported BYD on April 11th, one and a half months earlier than May 25th.

　　Why is it so late? Is it because the two sides have communicated beforehand? Or did the Great Wall ever think about keeping a low profile?

　　Perhaps none of the above reasons, but more likely because BYD’s new car Song Pro DM-i Champion Edition is scheduled to be released on the afternoon of May 25th.

　　On the day when the car was replaced, it was "disgusting" to have friends and businessmen, and the "sneak attack" of the Great Wall was well prepared.

　　Hammer you, although it didn’t reach the so-called "filing" in the report letter, the invisible damage caused is really real. It will change consumers’ minds invisibly-that is, BYD’s products are controversial and may have the behavior of "cutting corners".

　　Even if these things are proved to be untrue in the end, this cognitive change has caused a negative impression.

　　It doesn’t matter if you have any questions. But it’s important for consumers to feel "you have a problem".

　　The so-called business war is to attack the minds of consumers.

　　Of course, BYD’s response is also very interesting.

　　The whole response, eight paragraphs, seven exclamation points, an average of nearly one paragraph. The last three paragraphs, or even a single sentence into paragraphs, each sentence has an exclamation point. Anger and grievances are almost overflowing.

　　The last sentence is even more straightforward. "I hope everyone will do more things that are beneficial to the industry and the China brand!"

　　The implication is that what Great Wall has done is harmful to both the industry and the China brand.

　　Since you attacked first, don’t blame me for being rude.

　　In the past, the hero cherished the hero’s "North-South Double Heroes", thus breaking away. This situation reminds people of the kind advice of a 69-year-old veteran comrade-Wulin should value peace, emphasize martial arts and not engage in infighting.

　　Frankly speaking, last year’s metaphor of the Great Wall actually raised its own worth and secretly degraded BYD.

　　Today’s China auto market is no longer the era when Haval H6 dominated the world. Although the Great Wall is still in the first echelon of auto companies, it is far behind by BYD.

　　In 2022, BYD sold 1,863,500 new cars, with an operating income of 424.061 billion yuan, a year-on-year increase of 96.2%. The net profit attributable to shareholders of listed companies was 16.622 billion, up 445.86% year-on-year.

　　In contrast, the Great Wall sold only 1,061,700 new cars last year, with a total operating income of 137.34 billion yuan, a slight increase of 0.69% year-on-year; The net profit attributable to shareholders of listed companies was 8.266 billion yuan, a year-on-year increase of 22.90%.

　　For BYD, 2022 is undoubtedly a bumper year. It has become the champion of its own brand, the champion of global new energy vehicles, and the champion of China automobile market, and it has won many "firsts".

　　The Great Wall is still in a difficult transition in the switch between the old and new markets. The sales target of "1.9 million vehicles" set in 2022 was less than 60%. The sales of Haval, Wei Pai, Euler and pickup trucks under its control fell across the board, while the sales of new energy vehicles declined from 139,000 to 132,000 compared with the previous year.

　　If you don’t want to describe them as Qiao Feng and Mu Rongfu, you have to change your position, and you have lost Mu Rongfu after Wang Yuyan.

　　What I did was big brother

　　Many people believe that BYD’s rise is based on new energy sources.

　　This sentence is correct, but it is not detailed enough.

　　Pure trams are new energy, and hybrid cars are also new energy. The most important thing about BYD’s strong rise in the past two years is that plug-in hybrid vehicles have gained wide market recognition.

　　In 2021, BYD successively launched three models: Qin PLUS DM-i, Song PLUS DM-i and Tang DM-i, which achieved the coverage of the mainstream price range of 100,000-200,000.

　　As a result, in the second year, sales broke out. BYD sold 946,200 hybrid cars, accounting for 50.94% of the total sales. The sales volume of BYD Song PLUS DM-i alone was as high as 380,000.

　　The same thing happened in the whole China market. In 2022, the sales growth rate of plug-in hybrid vehicles reached 150% year-on-year, and the growth rate of ultra-pure electric vehicles was 82%.

　　Plug-in hybrid cars with green license, exemption from purchase tax, subsidy and electricity saving are the "wealth code" of China auto market.

　　Great Wall Motor certainly saw through this. Although it started later than BYD, it soon joined the research and development of hybrid technology. In 2018, Great Wall Motor developed a new hybrid platform, which is now the lemon hybrid DHT system.

　　However, consumers who know that "the Great Wall is also very mixed" are far from knowing that "BYD is very mixed". The reason is that the "coffee series" of the Great Wall really sells badly.

　　On the one hand, the positioning of Macchiato DHT is slightly higher than that of Song PLUS DM-i, and the entry version is 20,000 yuan higher; On the other hand, the naming of "Macchiato" is controversial, which leads to its poor market recognition. In the end, due to the small sales volume, consumers can’t perceive the hybrid technology of the Great Wall, which makes the Great Wall lose its first-Mover advantage.

　　If this technology had been devolved to Haval H6 earlier, it is likely that the current SUV hybrid market is by no means a monopoly of Song Plus DM-I.

　　The former Haval H6, which has won the championship for 100 consecutive months, is a well-deserved "magic car" in China. Until January of 2022, Haval H6 was still the dominant player in SUV field.

　　Unfortunately, it was not until mid-August of 2022 that the mixed version of Haval H6 came late. At this time, the sales volume of H6 has fallen to the fifth place, and not only Song PLUS has surpassed it, but also Yuan PLUS has surpassed it.

　　The failure to grasp the mixed outlet is an important reason why the Great Wall is now trapped in transformation and its sales volume has fallen sharply. I want to make the brand high-end and new energy at the same time, and finally the Great Wall of "one fish and two meals" failed to do both things well. Looking back, this is undoubtedly a strategic mistake of the Great Wall.

　　Although there are many consumers who sing the Great Wall, from the market value point of view, Great Wall Motor with a volume of 210 billion+is still the "second brother" after BYD.

　　This time, the "second brother" challenged the "big brother". Although it is somewhat embarrassing, it is also the norm in business competition.

　　Aboveboard peer supervision also protects the interests of consumers to some extent. If there is unfair competition, I believe that the relevant institutions will eventually give the enterprise an innocence and give a statement after verification.

　　

Leifeng. com reported on March 30th that Xin Huang, the former director of Xpeng Motors Autopilot Products, had joined Weilai as vice president, reporting directly to Li Bin, founder, chairman and CEO of Weilai.

In this regard, Xin Huang in the circle of friends suspected response: "false". It is understood that Xin Huang did join Weilai last year, but the position is senior director, not vice president.

During his tenure as Director of Autopilot Products in Xpeng Motors, Xin Huang promoted the implementation of NGP and memory parking projects in Tucki. In addition, Li Bin attaches great importance to the talents of autonomous driving technology, so Xin Huang’s level in Weilai is 6, after which his level in Tucki was 5. In this regard, Wei Lai also did not comment.

In July last year, it was reported by the media that Xin Huang had sent out six words in his personal circle of friends-"Thanksgiving, Goodbye and Best wishes", and it was suspected that he had left Xpeng Motors at that time.

Among many new car-making forces, Weilai has attracted much attention from the outside world since its establishment. A big reason is that its founders, Li Bin and Li Xiang, were once the bosses of the two largest vertical websites of automobiles in China.

In 2014, Li Binlian, the founder of Easy Car, together with car home Li Xiang, JD.COM and Tencent, invested and created a financing of 1 billion US dollars, and formally established Weilai, with the intention of building Tesla in China.

In the two years after its establishment, Weilai successively recruited a large number of senior executives from traditional car companies, who became the core entrepreneurs of Weilai Company in the early days, enabling Weilai to land in the capital market in just four years and complete the ringing of the bell on the New York Stock Exchange. These people include:

Qin Lihong, co-founder and legal representative of Weilai Automobile

Qin Lihong graduated from Peking University University of International Relations in 1999 with a master’s degree in law. In 2001, he obtained a master’s degree in public policy from Kennedy School of Government of Harvard University. In 2005, he joined Anhui Chery Automobile Sales Co., Ltd. as deputy general manager.

Zheng Xiancong, co-founder and executive vice president of Weilai Company.

In 2015, he officially joined Weilai, and together with Li Bin, he built the core team of the company, making contributions to the company in supply chain, industrialization and Weilai-driven technology.

Previously, he served as vice president of Fiat China Global Purchasing Center and general manager of gac fiat, and earlier worked for Ford, with nearly 40 years of experience in the automotive industry.

In August 2019, Zheng Xiancong announced his retirement. After retirement, he will continue to serve as the chairman of Weilai Drive Technology.

Martin Leach, former president and CEO of Weilai Automobile

Martin Leach has been working for Ford motor company for 24 years since 1979; In 2004, he served as CEO of Maserati; In 2006, he served as the president of GAZ Group, a Russian automobile company, in the UK. Since 2008, he has served as the vice chairman of Volvo Construction Equipment Group. In 2015, he joined NEXTEV Weilai as the president of the company.

He is not only a professional manager, but also an avid racing enthusiast. He became a kart driver when he was only 11 years old, and became a professional player at the age of 14. He has made great achievements in the field of karting and racing, and won several championship prizes in Europe.

In 2016, Martin Leach died unfortunately due to illness, at the age of 59.

Huang Chendong, Senior Vice President of Weilaiyuan

Huang Chendong is a Ph.D. in mechanical engineering from the University of Michigan, USA. He used to be the deputy general manager of the new energy division of SAIC. In March 2015, Huang Chendong joined Weilai, and was responsible for the core business of Weilai vehicle development, independent intelligent driving technology research and development, and electric power engineering.

In October 2019, Huang Chendong was promoted to senior vice president of Weilai, reporting to Li Bin. In June 2020, Wei Laiguan announced the news of Huang Chendong’s departure.

Padmasree Warrior, Chief Development Officer of Weilai and CEO of North American Company.

Joined Weilai in 2015, and together with Li Bin, promoted Weilai Automobile to become a competitive member of the global electric vehicle manufacturers. Before joining Weilai Automobile, Warrior was the chief technology officer and strategy officer of Cisco, and also served as the chief technology officer of Motorola. In December 2018, it officially announced its departure from Weilai.

In addition, Weilai Automobile also recruited Lu Xiaoming, the former chairman of Montblanc in China, to take charge of Weilai’s user experience. Zhong Wan Li, executive vice president of Jiangling, is responsible for the specific manufacturing. Ganesh V. Lyer, former chief information officer of Tesla, is the leader of Tesla’s ERP system and is responsible for the operation.

Ping Jiang, former vice president of Guangzhou Automobile Group, Zhou Xin, former executive director of automobile procurement and human resources and government affairs of Qoros, and Mao Jie, former executive director of automobile assembly of Qoros, and other senior executives are responsible for R&D, cost and manufacturing.

It can be said that at the beginning of its establishment, Weilai Automobile began to recruit a large number of senior executives, covering all aspects of automobile manufacturing.

In addition to founding the core figures in the early days, in recent years, Weilai has successively recruited many technical talents from well-known enterprises such as Huawei, NVIDIA, Wal-Mart, Xilinx and Huami.

Ren Shaoqing, co-founder and R&D director of Momenta, an autonomous driving startup.

In August 2020, Ren Shaoqing joined Weilai as assistant vice president, reporting directly to Weilai CEO Li Bin.

Ren Shaoqing graduated from the doctoral program jointly trained by the University of Science and Technology of China and Microsoft Asia Research Institute, and participated in proposing an efficient framework Faster RCNN and an image recognition algorithm ResNet for object detection.

The latter related papers won the Best Paper Award of CVPR, the top conference in the field of computer vision, in 2016.

In 2019, Momenta published an article saying that Ren Shaoqing ranked first in the world in adding academic citations to Google in autonomous driving, and accumulated academic citations ranked second in the world.

In addition, Ren Shaoqing was selected into the list of outstanding young people under the age of 30 in Forbes Asia in 2018.

Zhang Lei, Chief Architect of Yuan Hua Mi Technology

In August 2019, Zhang Lei joined Weilai Automobile as the vice president of software development, succeeding Dr. Li Zhuang.

Judging from the public information, Zhang Lei is a veteran of the automotive technology industry. In 2016, he joined the Huami Technology Silicon Valley team as the chief architect. Before joining Huami, Zhang Lei participated in the development of Android Auto, a car project.

After joining Weilai, Zhang Lei was mainly responsible for Weilai CDC (Car Digital Cockpit) business.

Hu Chengchen, former director of Xilinx Asia-Pacific Laboratory

According to public information, Hu Chengchen received his Ph.D. in computer science and technology in Tsinghua University in 2008, and then taught in Xi ‘an Jiaotong University for a long time. At the age of 29, he became an associate professor at the School of Telecommunications of Xi ‘an Jiaotong University, and later became a professor, and served as the head of the computer department of Xi ‘an Jiaotong University.

Its main research direction is data center, network big data and so on.

Later, in 2017, he was transferred from academia to industry, and served as the director /CTO of Xilinx Asia Pacific Laboratory, with rich experience in chip front-end design.

In October 2021, Hu Chengchen joined Weilai Automobile as the chief expert & assistant vice president and the head of the technical planning department.

Yin Shuijun, former president of Meitu mobile phone

(The picture on the right shows Yin Shuijun)

In February of this year, it was reported that Yin Shuijun, the former president of Meitu Mobile, joined Weilai to take the lead in the mobile phone business.

She Xiaoli, former chief functional safety expert of Huawei BU.

She Xiaoli graduated from Tsinghua University, worked as a functional safety expert in Baidu Autopilot Division for one year, and then worked as the chief functional safety expert and the chief big data application expert in Huawei.

According to public information, She Xiaoli joined Baidu (BIDU) in 2015 after receiving her Ph.D. in Tsinghua as a functional safety expert, and introduced the concept of functional safety into Baidu’s Autopilot Division.

A year later, he joined Huawei as the chief functional safety expert and the chief big data application expert, leading the design of vehicle-side data collection, cloud processing architecture and cloud value-added applications suitable for the characteristics of autonomous driving data.

In November 2021, She Xiaoli joined Weilai Automobile as an internal expert in algorithm research.

Zhang Xiaohong, former director of Huawei BU intelligent driving product project group.

Zhang Xiaohong graduated from Shanghai Jiaotong University with a major in mechanical engineering, and has served as a senior software development engineer of Shanghai Huawei Technologies Co., Ltd. and an OSS product director of Dingqiao Communication Technology Co., Ltd.

In April 2021, he joined Weilai as a senior product manager.

Steve Xie, former head of NVIDIA autopilot simulation.

On January 11th, 2022, Steve Xie, the former head of NVIDIA Autopilot Simulation, said that he had joined Weilai Automobile as the head and senior director of Autopilot Simulation Department of Shanghai Weilai Automobile Co., Ltd.

Steve Xie graduated from Peking University and received his Ph.D. from Columbia University. Judging from his work experience, Steve Xie had been deeply involved in the autonomous driving industry for many years before joining Weilai Automobile, and had working experience in Cruise, NVIDIA and other big manufacturers.

In 2018, Steve Xie joined Cruise, an American L4 autonomous driving company, responsible for simulation product development.

Alister Whelan, a former Jaguar Land Rover designer, and Joaquin Garcia, a former SEAT designer.

In October 2021, Whelan will become the design director of Weilai together with Garcia.

Alister Whelan had previously served as the interior design director in the design department of Jaguar Land Rover, and his career in Jaguar Land Rover was as long as 21 years, and he participated in the interior design of F-Type, F-Pace, I-Pace and other vehicles. Judging from his qualifications, he obviously has rich design experience.

Joaquin Garcia once worked in Skoda, a subsidiary of Volkswagen Group, for 5 years and in Seat for 6 years, and participated in the design work of Seat and its high-performance brand CUPRA.

Feng Li, Dean of BAIC New Technology Research Institute.

Feng Li comes from a technical background and knows a lot about automobile manufacturing. At the same time, he is also known as a "marketing wizard".

Previously, he worked in Chery Automobile, BAIC Group and other car companies, and has rich practice and successful experience in R&D, marketing, manufacturing and company management.

Since 2009, Feng Li has joined BAIC, successively serving as the executive deputy general manager of Beijing Hyundai, the president of Beijing Automotive Co., Ltd., the Standing Committee of the Party Committee of BAIC and the Party Secretary of the New Technology Research Institute of BAIC.

In December 2017, Feng Li joined Weilai Capital as a partner.

Bai Jian, former hardware director of OPPO and general manager of Xiaomi Chip and Forward-looking Research Department.

In November 2020, Bai Jian joined Weilai Automobile as vice president of hardware, reporting to Li Bin.

Before joining Xiaomi, Bai Jian worked for OPPO as the hardware director. In September 2018, Bai Jian joined Xiaomi Company as the general manager of Xiaomi Chip and Prospective Research Department. Bai Jian studied in Beijing University of Posts and Telecommunications, majoring in cryptography and communication engineering.

Zhu Jiang, former deputy general manager of Lexus China

In February 2017, Zhu Jiang joined Weilai Automobile as the vice president. In November, 2021, Zhu Jiang announced his resignation from Weilai and joined Jidu Automobile, a brand owned by Baidu Car, as the vice president of Jidu Automobile and the person in charge of user development and operation.

In 2002, Zhu Jiang began to set foot in the automobile industry, and then entered BMW Brilliance, responsible for dealer market, event marketing and other related work. In 2008, he was promoted to vice president of brand management of BMW China MINI.

In July 2014, he joined Lexus China as Deputy General Manager, mainly responsible for product planning and marketing.

Xie Dongying, former CFO of New Oriental

Xie Dongying worked in JPMorgan Chase, UBS Assets, UBS Investment Bank and other companies for many years, and then served as CFO of New Oriental Education Group, and once served as chief financial officer.

He is also a director of JD.COM, British education groups Noranda and Yum! China, and has helped many companies to complete the listing.

In May 2017, Weilai announced the appointment of personnel, and announced that Xie Dongying had joined as CFO, responsible for Weilai automobile financing and listing projects, and reported directly to Li Bin.

In October 2019, Xie Dongying left from Weilai.

Ralph kranz, former Volvo executive

In January, 2022, overseas media reported that Ralph Kranz, sales and commercial director of Volvo Germany, resigned on March 1st and joined Weilai Automobile to take charge of the German market.

According to public information, Ralph Kranz has many years’ experience in the automobile industry. Besides 10 years at Volvo, he also worked in aston martin and Toyota.

On the surface, it is wise for Weilai to dig kranz, mainly to promote the plan to enter the German market before the end of 2022.

Shen Feng, former Volvo executive.

In December 2017, the global CTO of Polestar, a high-performance brand owned by Volvo Cars, and Shen Feng, president of China and president of Volvo China R&D Company, announced that they had joined Weilai Automobile as vice president of quality and chairman of quality management committee, and were responsible for its overall quality-related management.

Volvo said that Shen Feng’s previous position in Polestar had been temporarily taken over by Lars Danielson.

Before joining Weilai, Shen Feng was a master of Ford 6-Sigma black belt, global CTO of Volvo Car Polestar and president of China, and president of Volvo China R&D Company.

Shen Feng has rich experience in 6-Sigma quality management, Geely Volvo International M&A, establishment of international R&D center, product R&D and mass production, supplier management, and establishment and commissioning of new factories.

　　[car home Information] Recently, we learned from the official that (|) once again ushered in the OTA upgrade, which was mainly aimed at optimizing the Yunnian -C system to improve its driving comfort. In addition, it also includes adding pet care mode, optimizing dynamic multi-color logic of atmosphere lights, etc., as follows:

Cloud chariot -C upgrade:

　　Optimize the Yunqi -C intelligent damping body control system, and the braking pitch suppression is increased by 20%, and the cornering roll suppression is increased by 12%, regardless of handling and comfort. This function upgrade corresponds to the vehicle configuration, and only applies to the models equipped with Yunnian-C.

Pet care mode:

Start the exclusive care for pets, automatically lock the doors and windows, start the anti-misoperation function in the car, keep the constant temperature air conditioning and make the air circulate freely. This mode upgrade is only applicable to Tengshi D9 EV models.

Optimizing dynamic multi-color logic of ambient light;

　　Ambient lights can realize independent control of the whole vehicle and its partitions, freely choose colors, show smart visual effects, and change with the rhythm of music. This function optimization is applicable to Tengshi D9 DM- car.

Optimizing the heating strategy of the main driver’s seat;

　　Optimize the heating time of the main driver’s seat without waking up many times. This function optimization is applicable to Tengshi D9 DM-i model.

Precautions:

　　1. This upgrade will be pushed nationwide in batches. Please be patient. If there is an urgent upgrade demand, please contact the nearest Tengshi Center for assistance. 2. This upgrade is mainly aimed at 22 and 23 Tengshi D9 models (the new Tengshi D9 models have been optimized and upgraded); 3. There may be differences due to vehicle configuration and other reasons. Please refer to the prompt information of the vehicle for the specific upgrade time; 4. This push takes a long time, so it is recommended to make an appointment to upgrade and reserve sufficient upgrade time; 5. This push will not consume user traffic and can be upgraded with confidence; 6. When upgrading, please park the vehicle on a gentle road to ensure that the vehicle network signal is good, the power is higher than 20%, and the front and rear doors and the front and rear hatch covers are closed; 7. During the upgrade process, the vehicle may appear short-term prompts such as off-screen, running lights on, dashboard failure, etc. These are normal phenomena. Please don’t intervene manually or forcibly power off and restart the vehicle. You can lock the vehicle normally and leave, and the vehicle will automatically complete the upgrade. 8. If you encounter any other problems during the upgrade, please call the user care hotline at 400-039-8888 for consultation. (Compile/car home Guo Chen)

　 　 　 　Luo Jing, the host of the famous News Network, Cindy Lee, the actor who plays Fang Yu in Deep Rain, and Fuck off! Tumor jun touched many netizens’ cartoonist Xiong Dun … In recent years, many celebrities have passed away because of lymphoma. At the same time, however, there are also many famous people who have succeeded in fighting cancer after suffering from lymphoma. For example, the 70-year-old famous director Wu Yusen was diagnosed with large B-cell lymphoma in tonsils when filming Taiping Wheel in 2008. After four operations, in the second month of chemotherapy, his mouth was all festered, he could not swallow, and his body and face were so thin that he was wrinkled. Finally, he succeeded in fighting cancer with his firm will! 　

　 　 　 　For example, Kai-Fu Lee, the founder of an innovative factory that successfully used chemotherapy and targeted therapy to fight advanced lymphoma! On September 5, 2013, 52-year-old Kai-fu Lee announced that he had stage IV follicular lymphoma and had to leave work for treatment. In February 2015, he announced the results of his physical examination, indicating that the tumor in the body is not obvious at present. In June of the same year, Kai-fu Lee said that he had not found any lesions in his last two examinations and ridiculed himself as "Li Kangfu". It took Kai-fu Lee less than two years from finding out the cancer until the focus was completely gone. His anti-cancer experience is worth learning from.

Alias "the most disguised disease", lymphoma has become a killer.

　 　 　 　According to statistics, there is a new case of lymphoma every 9 minutes in the world. The incidence of lymphoma in China is 0.02‰, with about 25,000 new patients and nearly 20,000 deaths each year. The threat of lymphoma is rapidly emerging. It ranks among the top ten malignant tumors in China and ranks second among hematological malignancies. At the beginning, the symptoms of the disease were hidden, and it was described as "the most disguised disease". In the intercontinental area, the incidence of non-Hodgkin’s lymphoma is much higher than Hodgkin’s disease, which is about 9: 1. Because of the higher degree of malignancy and worse prognosis, lymphoma is generally referred to as non-Hodgkin’s lymphoma. In China, the incidence of malignant tumors ranks ninth among men and tenth among women. Non-Hodgkin’s lymphoma can occur in all ages, and the high incidence age is 45~60 years old. Among them, Luo Jing suffered from diffuse large B-cell lymphoma (DLBCL). This is a common non-Hodgkin’s lymphoma, which belongs to aggressive lymphoma with high malignancy. The course of the disease progresses rapidly. If it is not actively treated, the median survival time is less than one year. In recent years, great progress has been made in the research and treatment of lymphoma, and new drugs and technologies have risen strongly! CAR-T therapy Among them, the chimeric antigen receptor T(CAR-T) cell therapy is particularly prominent. Its appearance represents a great progress in personalized cancer treatment, especially bringing the hope of rebirth to patients with hematological malignancies.

Complete remission! The first advanced lymphoma patient in China who received CAR-T therapy was discharged smoothly!

　 　 　 　Although they all suffer from diffuse large B-cell lymphoma, Mr. Chen, who suffers from malignant lymphoma, is a lucky one. According to Jiangsu public news channel News Space Station, on August 31st, the first lymphoma patient treated with CAR-T cells in China achieved complete remission and was discharged smoothly. 　

　 　 　 　Mr. Chen suffered from diffuse large B-cell lymphoma. After the onset of the disease in October 2010, he had received chemotherapy for many times, but all of them were unsatisfactory. Diffuse large B-cell lymphoma is the most common malignant lymphoma. After immunotherapy, about 60% patients can survive for a long time, but 40% patients will still relapse. In June this year, Mr. Chen accepted CAR-T cell therapy with a tentative attitude, and all the physical indicators tended to be normal. He told reporters with delight that his physical condition was better than before, and he was no different from a normal person after leaving the hospital. CAR-T therapy, a "living drug", made her completely relieved and looked forward to a cancer-free future.　

　 　 　 　As a "living" drug, CAR-T therapy is very different from traditional drugs. First, the therapy needs to isolate T cells from patients and modify them with chimeric antigen receptor (CAR) in vitro, so that they can specifically recognize cancer cells. Finally, the modified T cells are expanded and reinfused into patients. Compared with traditional chemotherapy and hematopoietic stem cell transplantation, it can kill tumor cells more accurately, improve the curative effect and greatly reduce the side effects. 　

The well-known director of hematology in China said: CAR-T can identify lymphoma very deliberately, and the antigen carried on tumor cells will attack directly after being connected, and it will produce an anti-tumor effect and kill it directly without the need for second signal stimulation, so one of its characteristics is accuracy, and the second is power. The scope of application is still the recurrence or refractory diffuse large B lymphoma that is ineffective in general immunochemotherapy. 　

CAR-T therapy FDA approved 6 models, and domestic CAR-T therapy caught up! 　　　

　 　 　 　After sharing the above news reports about CAR-T therapy, let’s get down to business and talk about CAR-T therapy. At present,CAR-T therapy has achieved great success in the treatment of hematological malignancies.. Six CAR-T cell therapies have been approved by FDA in the United States and two CAR-T cell therapies have been listed in China. The picture below shows CAR-T cell therapy that has been listed at home and abroad. 　 　　

　 　 　 　Although China’s CAR-T technology started late, the domestic market is large. According to the data on Clinicaltrials.gov’s website, China became the country that registered the most CAR-T tests in September 2017. As of May 27th, 2021, there are 1301 CAR-T clinical trials in the world, and the number of CAR-T trials registered in China has reached 478!　

01　　The first CAR-T therapy in China was approved for listing! China welcomes the first year of cellular immunotherapy.

　 　 　 　On June 22nd, the blank in the field of CAR-T in China was finally broken! The latest announcement of China National Medical Products Administration (NMPA), Fosun Kaite Biotechnology Co., Ltd. (hereinafter referred to as " Fosun Kate ”） The CAR-T cell therapy product targeting CD19, Aquilencel Injection (also known as Aquilencel, FKC876), was officially approved for marketing. This is the first approved CAR-T therapy in China and the sixth approved CAR-T therapy in the world. It is believed that China will usher in the blowout era of CAR-T cell therapy.　

02　　In just one month, the second CAR-T therapy in China and the sixth CAR-T therapy in the world were approved!

　 　 　 　On September 3, the State Drug Administration recently announced that Yaoming JunuoThe CAR-T product targeting CD19, Regiosai Injection.(relma-cel, trade name: Benoda) has been officially approved. The approved indications for Regioside Injection are:It can be used to treat relapsed or refractory large B-cell lymphoma (r/r LBCL) in adult patients after second-line or above systemic treatment.Reggiorense injection is the second CAR-T product approved in China and the first CAR-T product of Class 1 biological products in China.

　

It’s only been about one month since it was submitted for examination and approval on July 30th last time, which can be described as rapid progress. Congratulations! (At present, patients with economic conditions can contact cancer-free homes for the treatment of regiorense. )　

Boom! The first BCMA CAR-T therapy in China and the second in the world was approved by FDA!

　 　 　 　China’s "dark horse" in CAR-T cell therapy industry-legendary BCMA(B-cell mature antigen) CAR-T therapy Cedar-B38m/JNJ-4528 (hereinafter referred to as cilta-cel) has attracted much attention, and has shown excellent anticancer activity in clinical trials for multiple myeloma.

　 　 　 　What is exciting is that on February 28th, 2022, local time, it was jointly developed by Janssen and Legendary Biology.BCMA CAR-T product, Cedactylosin (trade name Carvykti), has been approved by the US FDA for the treatment of adult patients with relapsed/refractory multiple myeloma (MM).

This is the first cell therapy product approved by FDA in China and the second CAR-T cell immunotherapy approved for BCMA in the world.

　

　 　 　 　Cilta-cel was awarded priority review qualification by FDA on May 26th.However, the approval of the West Dachiorensai was delayed, and it was adjusted from November 29, 2021 toFebruary 28, 2022Fortunately, it was finally approved and lived up to expectations!

　 　 　 　cilta-celIt is a CAR-T therapy directed by research B cell maturation antigen (BCMA), which is used to treat relapsed or refractory multiple myeloma (RRMM). These patients received an average of five kinds of pre-treatment before treatment, 76% of them received five kinds of treatment, and 86% of them were resistant to five kinds of treatment, including CD38 treatment, and they were both resistant to protease inhibitor PI and immunomodulator IMiD. Simply put, it is refractory to relapse and lack of effective treatment in the follow-up. The principle of this CAR-T therapy is different from the current PD-1/L1. It directly uses the T cells in the patient’s body, transforms them in vitro, replicates them in large quantities, and then transfuses them into the patient’s body to kill cancer cells. At the ASH conference in 2021, the latest results of the 1b/2 CARTITUDE-1 study (n=97) showed that,meso-position 22 months Long-term follow-up, The objective remission rate (ORR) reached 98% , 83% patients achieved strict complete remission (sCR) It is emphasized that the mitigation will deepen with the passage of time (sCR will increase from 67% reported at the ASH annual meeting in 2020 to 83%). At 18 months, 66% of the patients were alive and the disease did not progress. .The two-year progression-free survival rate and overall survival rate are respectively 61% and 74% .The latest research results to be announced at the ASCO annual meeting in 2021 show that After a median follow-up of 18 months, the overall survival (OS) rate was 81%. The remission rate is comparable in all pre-specified subgroups and patients with different treatment lines.

　　 　

American research shows that cilta-cel has excellent long-term efficacy.　 　

　 　 　 　Emily, a foreign country, successfully ushered in nine years of cancer-free survival in 2021, and suddenly became the "spokesperson" of global CAR-T therapy. In China, there is such a lucky person whose fate has been completely changed by CAR-T therapy. Mr. Min was diagnosed with a special rare disease at the age of 54- multiple myeloma . He had no drugs available at that time, so he was lucky enough to participate in the clinical trial of CAR-T therapy. Although the treatment process was not smooth sailing, after three times of treatment, all the lumps on Mr. Min’s body disappeared and the pain disappeared. Surprisingly, by June 4, 2021, Mr. Min had lived cancer-free for five years, which is the field of cancer treatment, which is theoretically said. Clinical cure .

　 　 　 　In fact, as early as March 27th this year,The FDA approved the first CAR-T therapy targeting BCMA for adult patients with relapsed/refractory multiple myeloma (r/r MM) after receiving more than four therapies.

　 　 　 　Chemotherapy to fight cancer is often "killing one thousand enemies and losing eight hundred". Antibody drugs can accurately find tumor targets, but sometimes their combat effectiveness is insufficient. If we can put a "warhead" of chemotherapy drugs on antibody drugs, can we attack cancer cells more accurately? Based on this, an ADC (antibody drug conjugate) called "biological missile" was born. Antibody-coupled drugs are like biological missiles, which consist of two core functions: the first is antibody (missile body), the second is strong chemotherapy drug (nuclear warhead); This design will enable antibodies to find tumor cells with chemotherapy drugs, and then accurately poison tumor cells and poison them. 　This drug design combines the precision of targeted drugs with the high efficiency of chemotherapy drugs, which not only avoids the toxic and side effects of systemic use of chemotherapy drugs, but also has stronger killing ability than using targeted drugs alone, killing two birds with one stone. 　 　 　 　

Schematic diagram of antibody-coupled drugs 　 Note: (a) General description of A)ADC structure; (b) the mechanism of B)ADC. 　

Fourteen ADC drugs have been approved around the world, which brings hope for prolonging the survival time of back-line patients.

　 　 　 　At present, more than 100 kinds of ADC are undergoing clinical trials. Most adcs have progressed from phase i to phase II. Some ADC phase III trials show positive results; Up to September 20th, 2021, there are 14 kinds of ADC drugs on the market in the world, which are mainly used in hematological tumors and solid tumors, and are mainly used for back-line treatment of patients, including advanced, recurrent/refractory and metastatic tumor indications.

　

Fourteen ADC drugs have been approved worldwide.

According to the curative effect data, ADC drugs have brought more treatment options and the hope of prolonging the survival time for back-line patients, and the objective remission rate or median progression-free survival time of several drugs has doubled compared with chemotherapy.

Looking at the CD30 target, the new drug F0002-ADC became an instant hit and squeezed into the lymphoma track.

　 　 　 　CD30, a member of tumor necrosis factor (TNF) receptor superfamily, can promote cell proliferation or apoptosis by activating different signal pathways. In 2020, Vebtuximab for injection (Adcetris) was approved to be listed in China, and CD30 became famous. Adcetris, as an antibody-coupled drug targeting CD30, has an effective rate of 73% for Hodgkin’s lymphoma (HL) and 86% for anaplastic large cell lymphoma (ALCL). It is the first new drug approved in the field of Hodgkin’s lymphoma treatment in recent 30 years, and it is also the first time that a drug targeting CD30 has been approved, filling the gap in this field. At present, the only new ADC drug for CD30 in China is F0002-ADC. This new drug consists of three parts, namely, human-mouse chimeric anti-CD30 monoclonal antibody, thioether linker (MCC) and DM1. Since the project was launched in 2016, it has been disappointing! At present, patients with recurrent/refractory CD30 positive peripheral T-cell lymphoma are being recruited clinically! This is a new treatment option for patients with recurrent/refractory peripheral T-cell lymphoma!

This article is original for a cancer-free home, and it needs authorization to reprint! Cancer-free homes remind patients 　

Mercedes-Benz E-Class is a traditional luxury medium-sized and large-sized car product. For Biao and Audi a6l, its unique brand advantages and extreme luxury attributes have made it deeply recognized by consumers, with an average monthly sales volume of more than 13,000, which is in a strong competitive position in this market segment.

Mercedes-Benz e300l luxury design atmosphere, strong business atmosphere, the front shield-shaped mesh is quite eye-catching, two bar-type led light groups are shiny and recognizable, and the erected three-pointed star logo is also noble and elegant, which can always give people a strong psychological hint. The side is slender and smooth, the lines are smooth and sexy, the rear tail is sexy and stocky, the bilateral double exhaust is quite graded, and the overall face value is remarkable, which is a small S-class.

In terms of power, e300l is equipped with a 2.0t high-powered version, 190 kW, 370 Nm, equipped with a 9-speed manual, with a zero-hundred-speed score of about 6.6 seconds, which makes the acceleration feel smooth and calm at the beginning, and at the same time, the latter part is full of confidence and orderly shift logic, which is always indifferent and comfortable to drive, and can raise the speed to a very high level unconsciously.

In terms of structure, the training style is still very comfortable, the bumps on the road are handled in place, and there is not much impact when taking some bad roads. Driving is particularly heavy and advanced, which will definitely bring people the highest level of enjoyment, which is in line with the level that this level should have.

In terms of selling price, the official guide price of the 2019 Mercedes-Benz e300l Deluxe Edition is 492,800, with a preferential margin of about 40,000. The transaction price of the bare car at the terminal is 452,800, including 40080 purchase tax, 480 travel tax, 950 compulsory insurance, 12,299 commercial insurance and 500 licensed cars, totaling about 507,200.

Car experience:

Most satisfied with fashion and youth, cool atmosphere lights and a sense of science and technology in off the charts! 9-speed automatic transmission, almost no frustration!

The most dissatisfied with the sound effect is just so-so. The original car’s own sound is really lame, not as loud as Berlin’s.

[Space] The space in the front row of my 176 is quite large. There is not much horizontal space for two people. Three people are not very comfortable. From driving to now, I have only gone home for the Spring Festival, and I have been full of company group tours. Basically, I am alone.

[Power] The power is smooth between 234 gears, and occasionally, there will be some setbacks in oil collection.

[Control] Control is general, and this owner plays.

[Comfort] The front seat is comfortable and the rear seat is short.

[Appearance] I bought a sports label with pearl white. I feel very young. In fact, I am already young.

[Interior] Family-style design is adopted, just like driving an S. Due to the hasty booking of a car, the car comes with a black interior, which is a little depressing, but quite resistant to dirt.

[Cost-effective] If people like me don’t pay attention to performance, people who look at their eyes will buy a car of around 500,000, which is still very good.

Provided by the author