At present, all three models of Huawei P70 series have been connected to the network, and the certification information has been announced. According to the previous planning, the P70 series should be divided into three models: P70, P70 Pro and P70 Art According to the network access information, the standard version of P70 supports Beidou satellite message, while P70 Pro and P70 Art go further and support Beidou satellite message+Tiantong-1 satellite call.

In terms of specific configuration, the P70 series will adopt the Kirin 9000S chip with the same model as the Mate 60 series, supporting 5G, which is the first time that Huawei P series has returned to Kirin since P50.

Other specifications are also high-end, with 50-megapixel main camera, periscope telephoto lens, wireless charging and satellite communication technology as standard, which greatly improves the comprehensive strength of the standard version.

As for the oversized P70 Art, it will be further upgraded. The main camera will be replaced with IMX989 one-inch sensor, telephoto module and satellite communication technology, which will bring a stronger experience.

According to various sources, Huawei P70 series is likely to join the Pioneer Program like Mate 60 series and suddenly be put on the shelves in official website at 12:08 on a certain day in April.

On October 26th, at the Xiaomi new product launch conference, Xiaomi 14 Pro was officially released in the long-awaited event. The performance, image and quality of congruent-depth micro-curved screen, Xiaomi Longjing glass, Leica optical summilux lens and the third-generation Snapdragon 8 mobile platform have been comprehensively upgraded by leaps and bounds, and the comprehensive strength has gone further. The new products have lived up to the expectations of rice noodles and brought the charm of high-end flagship to the extreme.

Outstanding appearance of technological innovation

As the main supplier of glass back cover and metal middle frame of Xiaomi 14 Pro series mobile phones, Bourne Optics has always played an outstanding role, and together with Xiaomi, it has created a high-end flagship machine with amazing face value and extraordinary performance!

Xiaomi 14 Pro has three colors: white, black and rock blue. Bourne Optics exclusively supplies Xiaomi 14 Pro black and rock blue back cover. The black back cover is the first brand-new sandblasting AG process developed and designed by Bourne Optics and Xiaomi. Let the glass backboard keep the silky and delicate touch, at the same time, it has the graininess of frosting, and when it is turned lightly, it reveals a little luster, making each light soft and stable.

The new design concept and new technology require extremely strict parameters. Bourne Optics set up a special project team to tackle the research and development with customers, and conducted analysis and verification for more than two months and rounds, ranging from the whole process design to the accurate 1 second time difference and 1 temperature difference, giving each color a high-definition beauty.

The beauty of science and technology tends to the extreme.

Xiaomi 14 Pro’s unique and innovative technology optimizes the multi-layer stress of the panel, and the four sides and corners are bent in equal depth to form a beautiful arc. Light up the screen and have a borderless vision; Hold it in your hand and bring a cobblestone touch.

Paris nail deco shines with exquisite charm.

The brand-new Leica optical Summilux lens is adopted. The lens module is designed as a rounded rectangle, the top of the metal ring is treated with Paris nail pattern, and the side surface is polished, which is visually unified with the camera module on the back. The middle frame is a right angle without radian, which makes the whole fuselage look more tough and stylish.

Elegant and light design of high strength aluminum alloy metal middle frame

The biggest highlight of Xiaomi 14 Pro this time is the use of high-strength aluminum alloy metal middle frame, and the introduction of high-brightness anodized surface treatment process to make the sense and feel better. As the main supplier of the metal middle frame of Xiaomi 14 Pro mobile phone, Bourne Optics cooperated with Xiaomi team to carve every detail carefully, put forward more than 20 verification schemes, and developed and verified 100 polishing consumables (sponge sand, polishing wheel, polishing wax, polishing skin, polishing liquid and anti-corrosion liquid) for five months, finally locking the current polishing process. With strong R&D and precision manufacturing capabilities to overcome difficulties, every opening of the metal frame is smooth and delicate, and the simple lines perfectly fit the textured back cover, making Xiaomi 14 Pro exquisite and eye-catching.

Join hands to explore more exciting

From 2012 to 2023, Bourne Optics and Xiaomi started in-depth cooperation, established a joint laboratory and created a number of classic products. The successful application of new technologies and processes on Xiaomi 14 Pro at this conference has become another milestone in the cooperation between the two parties. In the future, Bourne Optics will continue to strengthen its independent innovation capability, continue to develop high-tech technologies, and explore more wonderful things together with Xiaomi with exquisite manufacturing technology.

　　[car home Information] Recently, we learned from the official that (|) once again ushered in the OTA upgrade, which was mainly aimed at optimizing the Yunnian -C system to improve its driving comfort. In addition, it also includes adding pet care mode, optimizing dynamic multi-color logic of atmosphere lights, etc., as follows:

Cloud chariot -C upgrade:

　　Optimize the Yunqi -C intelligent damping body control system, and the braking pitch suppression is increased by 20%, and the cornering roll suppression is increased by 12%, regardless of handling and comfort. This function upgrade corresponds to the vehicle configuration, and only applies to the models equipped with Yunnian-C.

Pet care mode:

Start the exclusive care for pets, automatically lock the doors and windows, start the anti-misoperation function in the car, keep the constant temperature air conditioning and make the air circulate freely. This mode upgrade is only applicable to Tengshi D9 EV models.

Optimizing dynamic multi-color logic of ambient light;

　　Ambient lights can realize independent control of the whole vehicle and its partitions, freely choose colors, show smart visual effects, and change with the rhythm of music. This function optimization is applicable to Tengshi D9 DM- car.

Optimizing the heating strategy of the main driver’s seat;

　　Optimize the heating time of the main driver’s seat without waking up many times. This function optimization is applicable to Tengshi D9 DM-i model.

Precautions:

　　1. This upgrade will be pushed nationwide in batches. Please be patient. If there is an urgent upgrade demand, please contact the nearest Tengshi Center for assistance. 2. This upgrade is mainly aimed at 22 and 23 Tengshi D9 models (the new Tengshi D9 models have been optimized and upgraded); 3. There may be differences due to vehicle configuration and other reasons. Please refer to the prompt information of the vehicle for the specific upgrade time; 4. This push takes a long time, so it is recommended to make an appointment to upgrade and reserve sufficient upgrade time; 5. This push will not consume user traffic and can be upgraded with confidence; 6. When upgrading, please park the vehicle on a gentle road to ensure that the vehicle network signal is good, the power is higher than 20%, and the front and rear doors and the front and rear hatch covers are closed; 7. During the upgrade process, the vehicle may appear short-term prompts such as off-screen, running lights on, dashboard failure, etc. These are normal phenomena. Please don’t intervene manually or forcibly power off and restart the vehicle. You can lock the vehicle normally and leave, and the vehicle will automatically complete the upgrade. 8. If you encounter any other problems during the upgrade, please call the user care hotline at 400-039-8888 for consultation. (Compile/car home Guo Chen)

　　[car home Car Information] We have made a separate investigation and analysis on the maintenance prices of conventional cars owned by Mercedes-Benz, BMW and Audi in the first two weeks. Today, we will make a big summary for everyone. Let’s take a look at the maintenance prices of these three brands.

---

　　As for the choice of vehicle types, we have chosen two relatively representative vehicles in each of the three basics: medium-sized cars, medium-sized cars and luxury cars. In the field of medium-sized cars, they are Mercedes-Benz C200K and C260, BMW 320i and 325i, and Audi A4L2.0T；; The fields of medium and large vehicles are Mercedes-Benz E200 and E300, BMW 523Li and 530Li, and Audi A6L 2.0T and 2.4. Luxury cars are Mercedes S300 and S600, BMW 730Li and 760Li, and Audi A8L 3.0L and 6.0L, with a total of 17 models.

---

Medium-sized cars: Mercedes-Benz C200K, C260, BMW 320i, 325i, Audi A4L2.0T

　　Among the three luxury mid-size cars, the sales volume of Audi A4L has an absolute advantage in this class, and the 2.0T model is the best-selling displacement among them, while the 1.8T and 3.2L models are neglected. The same situation also appears in BMW 3 Series and mercedes benz c Class cars. The sales of BMW 320i and Mercedes-Benz C200K are good, but at the same time, the market performance of BMW 325i and Mercedes-Benz C260 is ok. Let’s take a look at the maintenance prices of these seven cars.

Maintenance Price List of mercedes benz c Class, BMW 3 Series and Audi A4L (unit: RMB)
	Mercedes C200K	Mercedes-Benz C260	Bmw 320i	Bmw 325i	Audi A4L 2.0T
Minor maintenance: Oil maintenance (Replace the oil filter)	1725	2349	820	1115	860
Major maintenance: Oil maintenance+replace air conditioner filter and air filter.	4119	5077	1429	1768	2035
All prices in the tableIncluding accessories and working hours.
List of engine oil prices in Mercedes-Benz, BMW and Audi 4S stores
run quickly	Designated oil: Jin Mobil No.1 SM 0W-40 Price: 168 yuan/liter.
BMW	Original factory designated oil: Castrol Zun Hu SM 5W-30 Price: 125 yuan/liter Optional oil: Grey Shell SM 5W-40 Price: 125 yuan/liter
Audi	Original factory designated oil: Audi original engine oil 5W-40 SM price 93 yuan/liter. Optional oil: Castrol Zun Hu SM 0W-30 192 yuan/liter
Mercedes benz c Class, BMW 3 Series and Audi A4L three-car manufacturer’s specified maintenance cycle table.
cycle	run quickly		BMW		Audi
Minor maintenance	10,000 kilometers		10,000 kilometers		5,000 kilometers
Major maintenance	30,000 kilometers		30,000 kilometers		15,000 kilometers
Date of Form Collection: July 16th, 2010

"Beijing Benz mercedes benz c Class 2010 C200K Standard"

"BMW Brilliance BMW 3 Series 2010 320i Fashion Model"

"FAW Audi A4L 2010 2.0 TFSI Technology Type"

　　Judging from the price of routine maintenance, compared with Audi A4L and mercedes benz c, BMW 3 Series has obvious advantages in terms of both major maintenance and minor maintenance. The single maintenance price of Audi A4L model is moderate, but the maintenance price of mercedes benz c Class is obviously expensive, which is twice as high as that of BMW 3 Series basically listed.In terms of maintenance cycle, the original factories of Mercedes-Benz and BMW stipulate that 10,000 kilometers should be a minor maintenance and 30,000 kilometers should be a major maintenance, while Audi stipulates that 5,000 kilometers should be a minor maintenance and 15,000 kilometers should be a major maintenance, which is half of that of Mercedes-Benz and BMW. However, under normal circumstances, the staff of Mercedes-Benz and BMW 4S stores will advise the owners to do maintenance at 7000-8000 km, while Audi basically allows the owners to do maintenance at 7000-8000 km. Of course, the specific maintenance cycle will be determined according to the actual use of each car. Therefore, under normal circumstances, the actual maintenance cycle of these three cars is roughly the same.

"The original factory of Mercedes-Benz designated Jin Mobil No.1 SM 0W-40 all over synthetic engine oil"

"BMW original factory designated Castrol to protect SM 5W-30 all over synthetic engine oil"

"Audi original factory designated (Castrol OEM) SM 5W-40 all over synthetic engine oil"

　　In the choice of engine oil, these three luxury brands will naturally not be shabby, and SM-level synthetic engine oil is certain. Among them, the oil designated by Audi and BMW are all Castrol products. Of course, BMW will also provide two kinds of SM-grade all-synthetic engine oil products, namely Grey Shell and Jin Mobil No.1, according to the climate and environment of different 4S stores. As for Mercedes-Benz, there are not so many choices, so we just offer the 0W-40 all over synthetic engine oil. In terms of price, Audi is the cheapest, the unit price is 92 yuan/liter, followed by BMW at 125 yuan/liter, and Mercedes-Benz is relatively expensive at 168 yuan/liter.

　　At the same time, the editor needs to explain something here, about the amount of oil. Mercedes benz c-class cars have a big appetite. As a four-cylinder car, C200K can be said to have a considerable amount of better engine oil of 6L at a time. The oil consumption of V6 engines of C230, 260 and C300 is 8.5L. As a four-cylinder car, BMW 320i needs about 4.5L to change the oil once, and the oil consumption of the straight six engine of 325i model is about 6.5l.. The 2.0T engine oil consumption of Audi A4L is basically the same as that of BMW 320i, ranging from 4.5L to 5.0L..

For more details about the specific maintenance prices of the above seven models, please click the following icon to enter.

Mercedes benz C/E/S level maintenance survey, the minimum maintenance is 1,700 yuan.

Reveal the maintenance price of BMW car! Minimum 820 yuan once.

Small maintenance 860 yuan! Audi A4L/A6L/A8L Maintenance Survey

Medium and large cars: Mercedes-Benz E200, E300, BMW 523Li, 530Li and Audi A6L 2.0T, 2.4.

　　At present, in the field of medium and large-sized cars in China, Audi A6L has a higher dominance than Audi A4L in medium-sized cars. The annual sales of more than 100,000 vehicles are astounding, and the relatively low-end 2.0T and 2.4L models are the main sales products. With the development of domestic market in recent years, BMW 5 Series has also achieved good results. Among them, 523Li is the absolute main product, and 530Li has won the appreciation of some high-end users with its rich configuration and excellent power. As for Mercedes-Benz E-Class, although the market performance is average, we can’t ignore its existence with its golden signboard of "three-pointed star". Especially in recent months, with the lower price of imported Mercedes-Benz E-Class cars, the sales of Mercedes-Benz E-Class cars have a gradual upward trend. Among them, E200 and E300 are relatively representative. Let’s take a look at the maintenance price of these cars.

Maintenance price list of Mercedes-Benz E-Class, BMW 5 Series and Audi A6L (unit: RMB)
	Mercedes E200 1.8T M271	Mercedes-benz E300 3.0 V6 M272	Bmw 523Li	Bmw 530Li	Audi A6L 2.0T	Audi A6L 2.4
Minor maintenance: Oil maintenance (Replace the oil filter)	1783	2469	1115	1115	1351	1567
Major maintenance: Oil maintenance+replace air conditioner filter and air filter.	4028	4863	2246	2246	2743	2966
All prices in the tableIncluding accessories and working hours.
List of engine oil prices in Mercedes-Benz, BMW and Audi 4S stores
run quickly	Designated oil: Jin Mobil No.1 SM 0W-40 Price: 168 yuan/liter.
BMW	Original factory designated oil: Castrol Zun Hu SM 5W-30 Price: 125 yuan/liter Optional oil: Grey Shell SM 5W-40 Price: 125 yuan/liter
Audi	Original factory designated oil: Audi original engine oil 5W-40 SM price 93 yuan/liter. Optional oil: Castrol Zun Hu SM 0W-30 192 yuan/liter
Schedule of Maintenance Periods for Mercedes-Benz E-Class, BMW 5 Series and Audi A6L.
cycle	run quickly		BMW		Audi
Minor maintenance	10,000 kilometers		10,000 kilometers		5,000 kilometers
Major maintenance	30,000 kilometers		30,000 kilometers		15,000 kilometers
Date of Form Collection: July 16th, 2010

　　Judging from the price in the above table, the large maintenance cost of Mercedes-Benz E-Class is still the most expensive, but the small maintenance cost is reasonable. Take the E200CGI model with M271 1.8L in-line four-cylinder turbocharged engine as an example, the small maintenance price of replacing oil and machine filter is 1783 yuan, which is reasonable compared with the price of six-cylinder BMW 5 Series Xiaobao of 1115 yuan and Audi A6L with different displacement models of 1300-1600 yuan. But if it is replaced by a six-cylinder Mercedes E300 model, the price will be much more expensive.

"Mercedes-Benz (imported) Mercedes-Benz E-Class (imported) 09 E 300 Fashion Model"

"BMW Brilliance BMW 5 Series 2010 523Li Leading Model"

"FAW Audi A6L 2010 2.4 Comfort Type"

　　However, if we compare the large maintenance prices of the replacement oil filter, air filter and air conditioner filter of these three models, Mercedes-Benz is obviously much more expensive. Doing roughly the same maintenance content, the cost of Mercedes-Benz is basically twice that of BMW, and it is about 50% more expensive than Audi.

---

Luxury cars: Mercedes S300, S600, BMW 730Li, 760Li and Audi A8L 3.0L and 6.0L.

　　In the field of luxury cars, Mercedes-Benz BMW has finally found its face, and Mercedes-Benz S-Class can sit firmly in this basic model and it is difficult to shake in the short term. Bmw 7 series, with the launch of E66 in China, has also achieved good market performance. As for Audi A8L, although China has a special preference for this brand, it also has a certain sales volume, but it is much worse than Audi A6L and A4L. As for the choice of car models, the editor chose the entry-level Mercedes S300, BMW 730Li and Audi A8L 3.0, and their respective flagships, 12-cylinder models.

Maintenance price list of Mercedes-Benz S-Class, BMW 7 Series and Audi A8L (unit: RMB)
	Mercedes S300	Mercedes S600	Bmw 730Li	Bmw 760Li	Audi A8L 3.0	Audi A8L 6.0
Minor maintenance: Oil maintenance (Replace the oil filter)	2396	2486	1150	1448	1910	2801
Major maintenance: Oil maintenance+replace air conditioner filter and air filter.	5872	6215	2309	2986	3313	4480
All prices in the tableIncluding accessories and working hours.
List of engine oil prices in Mercedes-Benz, BMW and Audi 4S stores
run quickly	Designated oil: Jin Mobil No.1 SM 0W-40 Price: 168 yuan/liter.
BMW	Original factory designated oil: Castrol Zun Hu SM 5W-30 Price: 125 yuan/liter Optional oil: Grey Shell SM 5W-40 Price: 125 yuan/liter
Audi	Original factory designated oil: Audi original engine oil 5W-40 SM price 93 yuan/liter. Optional oil: Castrol Zun Hu SM 0W-30 192 yuan/liter
Schedule of Maintenance Periods for Mercedes-Benz S-Class, BMW 7 Series and Audi A8L
cycle	run quickly		BMW		Audi
Minor maintenance	10,000 kilometers		10,000 kilometers		5,000 kilometers
Major maintenance	30,000 kilometers		30,000 kilometers		15,000 kilometers
Date of Form Collection: July 16th, 2010

"Mercedes-Benz (imported) Mercedes-Benz S-Class S300L distinguished model"

"BMW (imported) BMW 7 Series 730Li Luxury Model"

"Audi (imported) Audi A8 2010 3.0 FSI Centennial Edition"

　　As a million-class luxury car, Mercedes-Benz S-Class, BMW 7 Series and Audi A8L can’t match the maintenance cost of these three models naturally, but judging from the small maintenance price of normal oil change and machine filter, BMW is still the cheapest of these three brands. Even the 760Li of V12 is less than 1,500 yuan at a time, which is quite surprising. The price difference between Mercedes-Benz S-Class and Audi A8L is not too much, both of which are around 2000-2500 yuan. Only Audi A8L 6.0L has a higher price, close to 3,000 yuan. As for the big maintenance cost, BMW is the cheapest, Audi is the second, and Mercedes is the most expensive. Among them, the price of Mercedes-Benz is twice that of BMW and about 50% more expensive than that of Audi, which is roughly the same as that of previous models.

Editor’s comment:

　　With the increasing competition in the domestic auto market, Mercedes-Benz, BMW and Audi, the three German luxury brands, are getting closer and closer to our lives. Nowadays, you can buy a BMW 318i, Audi A4L or Mercedes-Benz C180K for more than 200,000 yuan, and you can drive the BMW 5 Series, Audi A6L or the original imported Mercedes-Benz E-Class for about 400,000 yuan. Although on the whole, these cars are not very close to the people, in any case, compared with 10 years ago or even 5 years ago, they can be said to be a big step closer to the lives of the people.

　　But at the same time, we can often hear many people say that entry-level models of luxury brands such as Mercedes-Benz, BMW and Audi can afford them, but they can’t afford them. Today, the editor hopes that through this article, everyone can have a simple but systematic understanding of the general maintenance prices of these three brands of cars, hoping to help you choose, use and raise a car. At the same time, in the near future, we will launch more articles on the horizontal comparison of maintenance prices of the same grade vehicles, so please look forward to it. (Text/car home Sheng Yuanjun)

For more details about the maintenance of Mercedes-Benz, BMW and Audi cars and the price of conventional wearing parts, please click the following icon to enter.

Mercedes benz C/E/S level maintenance survey, the minimum maintenance is 1,700 yuan.

Reveal the maintenance price of BMW car! Minimum 820 yuan once.

Small maintenance 860 yuan! Audi A4L/A6L/A8L Maintenance Survey

　 　 　 　Luo Jing, the host of the famous News Network, Cindy Lee, the actor who plays Fang Yu in Deep Rain, and Fuck off! Tumor jun touched many netizens’ cartoonist Xiong Dun … In recent years, many celebrities have passed away because of lymphoma. At the same time, however, there are also many famous people who have succeeded in fighting cancer after suffering from lymphoma. For example, the 70-year-old famous director Wu Yusen was diagnosed with large B-cell lymphoma in tonsils when filming Taiping Wheel in 2008. After four operations, in the second month of chemotherapy, his mouth was all festered, he could not swallow, and his body and face were so thin that he was wrinkled. Finally, he succeeded in fighting cancer with his firm will! 　

　 　 　 　For example, Kai-Fu Lee, the founder of an innovative factory that successfully used chemotherapy and targeted therapy to fight advanced lymphoma! On September 5, 2013, 52-year-old Kai-fu Lee announced that he had stage IV follicular lymphoma and had to leave work for treatment. In February 2015, he announced the results of his physical examination, indicating that the tumor in the body is not obvious at present. In June of the same year, Kai-fu Lee said that he had not found any lesions in his last two examinations and ridiculed himself as "Li Kangfu". It took Kai-fu Lee less than two years from finding out the cancer until the focus was completely gone. His anti-cancer experience is worth learning from.

Alias "the most disguised disease", lymphoma has become a killer.

　 　 　 　According to statistics, there is a new case of lymphoma every 9 minutes in the world. The incidence of lymphoma in China is 0.02‰, with about 25,000 new patients and nearly 20,000 deaths each year. The threat of lymphoma is rapidly emerging. It ranks among the top ten malignant tumors in China and ranks second among hematological malignancies. At the beginning, the symptoms of the disease were hidden, and it was described as "the most disguised disease". In the intercontinental area, the incidence of non-Hodgkin’s lymphoma is much higher than Hodgkin’s disease, which is about 9: 1. Because of the higher degree of malignancy and worse prognosis, lymphoma is generally referred to as non-Hodgkin’s lymphoma. In China, the incidence of malignant tumors ranks ninth among men and tenth among women. Non-Hodgkin’s lymphoma can occur in all ages, and the high incidence age is 45~60 years old. Among them, Luo Jing suffered from diffuse large B-cell lymphoma (DLBCL). This is a common non-Hodgkin’s lymphoma, which belongs to aggressive lymphoma with high malignancy. The course of the disease progresses rapidly. If it is not actively treated, the median survival time is less than one year. In recent years, great progress has been made in the research and treatment of lymphoma, and new drugs and technologies have risen strongly! CAR-T therapy Among them, the chimeric antigen receptor T(CAR-T) cell therapy is particularly prominent. Its appearance represents a great progress in personalized cancer treatment, especially bringing the hope of rebirth to patients with hematological malignancies.

Complete remission! The first advanced lymphoma patient in China who received CAR-T therapy was discharged smoothly!

　 　 　 　Although they all suffer from diffuse large B-cell lymphoma, Mr. Chen, who suffers from malignant lymphoma, is a lucky one. According to Jiangsu public news channel News Space Station, on August 31st, the first lymphoma patient treated with CAR-T cells in China achieved complete remission and was discharged smoothly. 　

　 　 　 　Mr. Chen suffered from diffuse large B-cell lymphoma. After the onset of the disease in October 2010, he had received chemotherapy for many times, but all of them were unsatisfactory. Diffuse large B-cell lymphoma is the most common malignant lymphoma. After immunotherapy, about 60% patients can survive for a long time, but 40% patients will still relapse. In June this year, Mr. Chen accepted CAR-T cell therapy with a tentative attitude, and all the physical indicators tended to be normal. He told reporters with delight that his physical condition was better than before, and he was no different from a normal person after leaving the hospital. CAR-T therapy, a "living drug", made her completely relieved and looked forward to a cancer-free future.　

　 　 　 　As a "living" drug, CAR-T therapy is very different from traditional drugs. First, the therapy needs to isolate T cells from patients and modify them with chimeric antigen receptor (CAR) in vitro, so that they can specifically recognize cancer cells. Finally, the modified T cells are expanded and reinfused into patients. Compared with traditional chemotherapy and hematopoietic stem cell transplantation, it can kill tumor cells more accurately, improve the curative effect and greatly reduce the side effects. 　

The well-known director of hematology in China said: CAR-T can identify lymphoma very deliberately, and the antigen carried on tumor cells will attack directly after being connected, and it will produce an anti-tumor effect and kill it directly without the need for second signal stimulation, so one of its characteristics is accuracy, and the second is power. The scope of application is still the recurrence or refractory diffuse large B lymphoma that is ineffective in general immunochemotherapy. 　

CAR-T therapy FDA approved 6 models, and domestic CAR-T therapy caught up! 　　　

　 　 　 　After sharing the above news reports about CAR-T therapy, let’s get down to business and talk about CAR-T therapy. At present,CAR-T therapy has achieved great success in the treatment of hematological malignancies.. Six CAR-T cell therapies have been approved by FDA in the United States and two CAR-T cell therapies have been listed in China. The picture below shows CAR-T cell therapy that has been listed at home and abroad. 　 　　

　 　 　 　Although China’s CAR-T technology started late, the domestic market is large. According to the data on Clinicaltrials.gov’s website, China became the country that registered the most CAR-T tests in September 2017. As of May 27th, 2021, there are 1301 CAR-T clinical trials in the world, and the number of CAR-T trials registered in China has reached 478!　

01　　The first CAR-T therapy in China was approved for listing! China welcomes the first year of cellular immunotherapy.

　 　 　 　On June 22nd, the blank in the field of CAR-T in China was finally broken! The latest announcement of China National Medical Products Administration (NMPA), Fosun Kaite Biotechnology Co., Ltd. (hereinafter referred to as " Fosun Kate ”） The CAR-T cell therapy product targeting CD19, Aquilencel Injection (also known as Aquilencel, FKC876), was officially approved for marketing. This is the first approved CAR-T therapy in China and the sixth approved CAR-T therapy in the world. It is believed that China will usher in the blowout era of CAR-T cell therapy.　

02　　In just one month, the second CAR-T therapy in China and the sixth CAR-T therapy in the world were approved!

　 　 　 　On September 3, the State Drug Administration recently announced that Yaoming JunuoThe CAR-T product targeting CD19, Regiosai Injection.(relma-cel, trade name: Benoda) has been officially approved. The approved indications for Regioside Injection are:It can be used to treat relapsed or refractory large B-cell lymphoma (r/r LBCL) in adult patients after second-line or above systemic treatment.Reggiorense injection is the second CAR-T product approved in China and the first CAR-T product of Class 1 biological products in China.

　

It’s only been about one month since it was submitted for examination and approval on July 30th last time, which can be described as rapid progress. Congratulations! (At present, patients with economic conditions can contact cancer-free homes for the treatment of regiorense. )　

Boom! The first BCMA CAR-T therapy in China and the second in the world was approved by FDA!

　 　 　 　China’s "dark horse" in CAR-T cell therapy industry-legendary BCMA(B-cell mature antigen) CAR-T therapy Cedar-B38m/JNJ-4528 (hereinafter referred to as cilta-cel) has attracted much attention, and has shown excellent anticancer activity in clinical trials for multiple myeloma.

　 　 　 　What is exciting is that on February 28th, 2022, local time, it was jointly developed by Janssen and Legendary Biology.BCMA CAR-T product, Cedactylosin (trade name Carvykti), has been approved by the US FDA for the treatment of adult patients with relapsed/refractory multiple myeloma (MM).

This is the first cell therapy product approved by FDA in China and the second CAR-T cell immunotherapy approved for BCMA in the world.

　

　 　 　 　Cilta-cel was awarded priority review qualification by FDA on May 26th.However, the approval of the West Dachiorensai was delayed, and it was adjusted from November 29, 2021 toFebruary 28, 2022Fortunately, it was finally approved and lived up to expectations!

　 　 　 　cilta-celIt is a CAR-T therapy directed by research B cell maturation antigen (BCMA), which is used to treat relapsed or refractory multiple myeloma (RRMM). These patients received an average of five kinds of pre-treatment before treatment, 76% of them received five kinds of treatment, and 86% of them were resistant to five kinds of treatment, including CD38 treatment, and they were both resistant to protease inhibitor PI and immunomodulator IMiD. Simply put, it is refractory to relapse and lack of effective treatment in the follow-up. The principle of this CAR-T therapy is different from the current PD-1/L1. It directly uses the T cells in the patient’s body, transforms them in vitro, replicates them in large quantities, and then transfuses them into the patient’s body to kill cancer cells. At the ASH conference in 2021, the latest results of the 1b/2 CARTITUDE-1 study (n=97) showed that,meso-position 22 months Long-term follow-up, The objective remission rate (ORR) reached 98% , 83% patients achieved strict complete remission (sCR) It is emphasized that the mitigation will deepen with the passage of time (sCR will increase from 67% reported at the ASH annual meeting in 2020 to 83%). At 18 months, 66% of the patients were alive and the disease did not progress. .The two-year progression-free survival rate and overall survival rate are respectively 61% and 74% .The latest research results to be announced at the ASCO annual meeting in 2021 show that After a median follow-up of 18 months, the overall survival (OS) rate was 81%. The remission rate is comparable in all pre-specified subgroups and patients with different treatment lines.

　　 　

American research shows that cilta-cel has excellent long-term efficacy.　 　

　 　 　 　Emily, a foreign country, successfully ushered in nine years of cancer-free survival in 2021, and suddenly became the "spokesperson" of global CAR-T therapy. In China, there is such a lucky person whose fate has been completely changed by CAR-T therapy. Mr. Min was diagnosed with a special rare disease at the age of 54- multiple myeloma . He had no drugs available at that time, so he was lucky enough to participate in the clinical trial of CAR-T therapy. Although the treatment process was not smooth sailing, after three times of treatment, all the lumps on Mr. Min’s body disappeared and the pain disappeared. Surprisingly, by June 4, 2021, Mr. Min had lived cancer-free for five years, which is the field of cancer treatment, which is theoretically said. Clinical cure .

　 　 　 　In fact, as early as March 27th this year,The FDA approved the first CAR-T therapy targeting BCMA for adult patients with relapsed/refractory multiple myeloma (r/r MM) after receiving more than four therapies.

　 　 　 　Chemotherapy to fight cancer is often "killing one thousand enemies and losing eight hundred". Antibody drugs can accurately find tumor targets, but sometimes their combat effectiveness is insufficient. If we can put a "warhead" of chemotherapy drugs on antibody drugs, can we attack cancer cells more accurately? Based on this, an ADC (antibody drug conjugate) called "biological missile" was born. Antibody-coupled drugs are like biological missiles, which consist of two core functions: the first is antibody (missile body), the second is strong chemotherapy drug (nuclear warhead); This design will enable antibodies to find tumor cells with chemotherapy drugs, and then accurately poison tumor cells and poison them. 　This drug design combines the precision of targeted drugs with the high efficiency of chemotherapy drugs, which not only avoids the toxic and side effects of systemic use of chemotherapy drugs, but also has stronger killing ability than using targeted drugs alone, killing two birds with one stone. 　 　 　 　

Schematic diagram of antibody-coupled drugs 　 Note: (a) General description of A)ADC structure; (b) the mechanism of B)ADC. 　

Fourteen ADC drugs have been approved around the world, which brings hope for prolonging the survival time of back-line patients.

　 　 　 　At present, more than 100 kinds of ADC are undergoing clinical trials. Most adcs have progressed from phase i to phase II. Some ADC phase III trials show positive results; Up to September 20th, 2021, there are 14 kinds of ADC drugs on the market in the world, which are mainly used in hematological tumors and solid tumors, and are mainly used for back-line treatment of patients, including advanced, recurrent/refractory and metastatic tumor indications.

　

Fourteen ADC drugs have been approved worldwide.

According to the curative effect data, ADC drugs have brought more treatment options and the hope of prolonging the survival time for back-line patients, and the objective remission rate or median progression-free survival time of several drugs has doubled compared with chemotherapy.

Looking at the CD30 target, the new drug F0002-ADC became an instant hit and squeezed into the lymphoma track.

　 　 　 　CD30, a member of tumor necrosis factor (TNF) receptor superfamily, can promote cell proliferation or apoptosis by activating different signal pathways. In 2020, Vebtuximab for injection (Adcetris) was approved to be listed in China, and CD30 became famous. Adcetris, as an antibody-coupled drug targeting CD30, has an effective rate of 73% for Hodgkin’s lymphoma (HL) and 86% for anaplastic large cell lymphoma (ALCL). It is the first new drug approved in the field of Hodgkin’s lymphoma treatment in recent 30 years, and it is also the first time that a drug targeting CD30 has been approved, filling the gap in this field. At present, the only new ADC drug for CD30 in China is F0002-ADC. This new drug consists of three parts, namely, human-mouse chimeric anti-CD30 monoclonal antibody, thioether linker (MCC) and DM1. Since the project was launched in 2016, it has been disappointing! At present, patients with recurrent/refractory CD30 positive peripheral T-cell lymphoma are being recruited clinically! This is a new treatment option for patients with recurrent/refractory peripheral T-cell lymphoma!

This article is original for a cancer-free home, and it needs authorization to reprint! Cancer-free homes remind patients 　

Mercedes-Benz E-Class is a traditional luxury medium-sized and large-sized car product. For Biao and Audi a6l, its unique brand advantages and extreme luxury attributes have made it deeply recognized by consumers, with an average monthly sales volume of more than 13,000, which is in a strong competitive position in this market segment.

Mercedes-Benz e300l luxury design atmosphere, strong business atmosphere, the front shield-shaped mesh is quite eye-catching, two bar-type led light groups are shiny and recognizable, and the erected three-pointed star logo is also noble and elegant, which can always give people a strong psychological hint. The side is slender and smooth, the lines are smooth and sexy, the rear tail is sexy and stocky, the bilateral double exhaust is quite graded, and the overall face value is remarkable, which is a small S-class.

In terms of power, e300l is equipped with a 2.0t high-powered version, 190 kW, 370 Nm, equipped with a 9-speed manual, with a zero-hundred-speed score of about 6.6 seconds, which makes the acceleration feel smooth and calm at the beginning, and at the same time, the latter part is full of confidence and orderly shift logic, which is always indifferent and comfortable to drive, and can raise the speed to a very high level unconsciously.

In terms of structure, the training style is still very comfortable, the bumps on the road are handled in place, and there is not much impact when taking some bad roads. Driving is particularly heavy and advanced, which will definitely bring people the highest level of enjoyment, which is in line with the level that this level should have.

In terms of selling price, the official guide price of the 2019 Mercedes-Benz e300l Deluxe Edition is 492,800, with a preferential margin of about 40,000. The transaction price of the bare car at the terminal is 452,800, including 40080 purchase tax, 480 travel tax, 950 compulsory insurance, 12,299 commercial insurance and 500 licensed cars, totaling about 507,200.

Car experience:

Most satisfied with fashion and youth, cool atmosphere lights and a sense of science and technology in off the charts! 9-speed automatic transmission, almost no frustration!

The most dissatisfied with the sound effect is just so-so. The original car’s own sound is really lame, not as loud as Berlin’s.

[Space] The space in the front row of my 176 is quite large. There is not much horizontal space for two people. Three people are not very comfortable. From driving to now, I have only gone home for the Spring Festival, and I have been full of company group tours. Basically, I am alone.

[Power] The power is smooth between 234 gears, and occasionally, there will be some setbacks in oil collection.

[Control] Control is general, and this owner plays.

[Comfort] The front seat is comfortable and the rear seat is short.

[Appearance] I bought a sports label with pearl white. I feel very young. In fact, I am already young.

[Interior] Family-style design is adopted, just like driving an S. Due to the hasty booking of a car, the car comes with a black interior, which is a little depressing, but quite resistant to dirt.

[Cost-effective] If people like me don’t pay attention to performance, people who look at their eyes will buy a car of around 500,000, which is still very good.

Provided by the author

　　Since the beginning of January this year, residents of Weicheng Town, Guiyang City, located in the mountainous area of Guizhou Province, have often seen a drone shuttle through the town. Under the belly of the plane, there was a box with the words "China Post". The local people later learned that this drone was used by the post office in the town to deliver mail to the surrounding mountain villages. Beijing Youth Daily reporter learned from the local post office on the 15th that this drone now flies twice a week, and it will be promoted if it works well in the future.

　　Postman part-time drone operator

　　On the morning of 15th, Wang Hua, a staff member of Weicheng Post Sub-bureau in Guiyang, took his drone to an open space near the town, and prepared to deliver newspapers and some mails to five villages around the town.

　　Wang Hua is a postman. He used to ride a motorcycle to deliver mail to several surrounding villages three times a week. Because the mountain road is rugged, although the distance is not far, it takes a whole day to deliver it every time. Since the beginning of January this year, Wang Hua has added a new task, which is to operate drones to transport mail.

　　"Our economy is not developed here. Many people have never seen drones, so many people gathered around to see them when they first started flying. Some old people asked us about the timetable for flying drones and came to see them several times." Wang Hua said.

　　Wang Hua said that he is driving a drone, but in fact the main operation is not done by him. He is mainly responsible for loading mail on the drone and then checking the battery. The flight route has long been set by the company that developed the drone. All he has to do is scan the QR code on the plane with his mobile phone, and then click the start button on the mobile phone, and the plane can fly according to the pre-designed route.

　　"It used to take a whole day to send the mail from these villages by motorcycle. Now the whole route is flown by drones, which is more than an hour." Wang Hua said.

　　Flying to every village requires changing batteries.

　　Director Chen Zhongxiang of Weicheng Post Sub-office told the reporter of Beiqing Daily that at present, there is only one drone in the town post office, and they selected five villages, namely Yingyan, Yinqiao, Maixiang, Xingguang and Lianhua Temple, as delivery pilots. Chen Zhongxiang said that these villages were chosen because they are relatively remote, and it takes too long and the road is dangerous to send mail into the village by manpower.

　　Chen Zhongxiang said that the UAV they are using now has a diameter of more than 1 meter and six propellers. In theory, it can carry about 7 kilograms of goods. However, for safety reasons, the stipulated delivery weight is no more than 5 kilograms, and the flying distance between villages is about 10 minutes. Every time you fly to a village, you need people from the village to help replace the new battery, and then you can fly to the next village. The whole journey is a "relay" process.

　　"The plane must be fully charged before it can take off. The last time we saw the power of the plane was 82%, we felt that we could complete a flight, but after the start, the plane still could not take off. This may be the design made by the aircraft research and development enterprise for the absolute safety of the aircraft." Chen Zhongxiang said.

　　Temporarily unable to replace manual delivery.

　　According to the staff of the UAV R&D company, when the plane lands, it needs to lay a red and blue positioning carpet at the landing site. The UAV is equipped with a sensor in the vertical direction. When it searches for the positioning carpet, it will land accurately. Location.

　　Chen Zhongxiang told the reporter of Beiqing Daily that it was not the decision of the town post office to equip the town post office with drones, but the higher authorities chose the Weicheng post office as a pilot. If the use effect is good in the future, it will continue to be promoted.

　　"Many people in the village felt particularly fresh when they saw the plane at first, and the people in charge of managing the plane in each village also had a WeChat group. When the plane took off and landed, everyone would inform each other."

　　Annabelle of Xingguang Village Committee is one of the managers of this drone. Every time he receives the mail from his village, he also needs to replace the plane with a new battery. "If the battery is not fully charged, the plane can’t fly, but there will definitely be no forgetting to charge the battery. Everyone will remind each other when they have WeChat groups."

　　Chen Zhongxiang said that in the past, the postman of the post office had to go into the mountain three times a week, but now it has been reduced to twice a week, while the drone now flies twice a week. If the effect is good in the future, it will increase the flight frequency. "But due to the limitation of load, drones can’t completely replace the postman now, and everywhere they go, they need people to get express delivery for batteries. There are still some troubles. It would be nice if these jobs can be replaced by machines in the future."

　　Text/reporter Fu Wei

On October 24th, after the incident of eyebrow pencil in 79 yuan, the live broadcast room in Li Jiaqi broadcasted Huaxizi with goods again after 43 days. However, Li Jiaqi himself did not appear to explain the product of Huaxizi, and the controversial ace product Huaxizi eyebrow pencil did not appear in the live broadcast list. According to Time Finance, Hua Xizi’s performance in the live broadcast room in Li Jiaqi is still good, but compared with last year, it is much worse.

I and the disputed eyebrow pencil did not appear.

In the list of products with goods in Li Jiaqi Live Studio, there are three products owned by Hua Xizi, namely, a combination suit of 357 yuan, a powder cake of 149 yuan and honey powder of 129 yuan. According to Time Finance, at 8 pm, the live broadcast room in Li Jiaqi exceeded 10 million people. After the countdown was displayed on the screen, the gongs and drums in Li Jiaqi’s hand were sounded, and the pre-sale of Tmall "double 11" officially kicked off this year.

As soon as the live broadcast was started, more than 7,000 pieces, 3,000 pieces and 300 groups of Huaxizi air honey powder, Yurong gauze powder cake and water hibiscus in the Li Jiaqi live broadcast room had been booked respectively. At 8: 02, more than 20,000 pieces, 9,000 pieces and 1,000 pieces of three groups of products were ordered respectively. The figures will change every few minutes. By 10: 30 pm, the pre-sales of the above three groups of products exceeded 70,000, 3,000 and 30,000 respectively. According to Red Net, as of 11: 30 p.m. on 24th, the amount of honey powder with a price of 129 yuan for Huaxizi has exceeded 80,000 orders, the amount of powder cake with a price of 149 yuan has exceeded 30,000 orders, and the combined set with a price of 357 yuan has exceeded 3,000 orders, totaling more than 110,000 orders.

Although Hua Xizi’s performance in the live broadcast room in Li Jiaqi is still good, compared with last year, it is much worse. According to previous media reports, at 9: 00 pm on October 24th, 2022, the colored powder cake of Huaxizi Yurongsha was first released in the live broadcast room in Li Jiaqi. After only 15 minutes on the shelves, 250,000 colored powder cakes were sold out. According to Time Finance’s analysis, in addition to the previous storm, the sales volume of Hua Xizi was affected, and this sales performance may be related to the fact that Hua Xizi did not appear in the prime time of the live broadcast room in Li Jiaqi this year. According to Red Net, as of 11: 30 pm on the 24th, the number of viewers in the live broadcast room in Li Jiaqi was still at 10 million+.

The controversial ace product Hua Xizi eyebrow pencil did not appear in the live broadcast list. According to Time Finance, in the live broadcast room of Huaxi’s official flagship store, the anchor said that the eyebrow pencil "double 11" activity had not been announced. In the live commentary area, some netizens said bluntly: "I will never buy it again, which is really sad" and "How dare he"; However, some netizens said: "Although I am not interested in Hua Xizi, I am still interested in the things in the live broadcast room in Li Jiaqi."

Hua Xizi deeply binds Li Jiaqi.

Earlier, on September 10th, when Li Jiaqi introduced a Huaxizi Eyebrow Pencil in 79 yuan, he saw a message from a netizen saying it was expensive, and replied that 79 yuan Eyebrow Pencil could not be bought because he didn’t work hard enough. At the same time, it was exposed that 79 yuan Eyebrow Pencil was only 0.08 grams more expensive than gold, which led the netizens to think that Li Jiaqi despised ordinary people, created anxiety and inflated commodity prices.

In the early morning of September 11th, Li Jiaqi posted a blog post apologizing, and released an apology video on the evening of the same day, saying that his inappropriate remarks disappointed everyone, and he would also reflect on why he started in the first place and how he could serve more girls. Thank you again for your criticism and supervision. However, many netizens said that they "don’t buy it" for Li Jiaqi’s apology, and joked "Where ‘ Li ’ Wrong? " According to Xinmin Evening News, before the eyebrow pencil incident in 79 yuan, the number of fans in Weibo, Li Jiaqi was 30.435 million. By 11: 00 on October 24th, the number of fans was 28.747 million, and the number of fans dropped by over 1.68 million.

According to the International Finance News, four years ago, Hua Xizi announced Li Jiaqi as the chief recommender of the brand. At that time, this little-known brand was established only two years ago. With the help of the flow of "lipstick brother", the sales of Huaxizi reached 1.13 billion yuan that year, which was 25 times higher than that of 2018. The deep binding between the two parties began in 2019. According to the magic mirror data, the sales of Huaxizi’s star product, carved lipstick, increased by 165% month-on-month after it was promoted by Li Jiaqi multi-platform in May of that year. On the battlefield of "double 11", Hua Xizi never missed the live studio in Li Jiaqi from the pre-sale stage, and with the help of Li Jiaqi’s strong ability to carry goods, he won 220 million yuan GMV for the first time in the war and became the second place in domestic beauty cosmetics.

Around the "double 11" in that year, the live broadcast room in Li Jiaqi contributed 64% of the total turnover of Huaxizi. In June, 2022, Li Jiaqi stopped broadcasting for some reason. During the "June 18th Promotion" period, the sales of Huaxizi, who lost Li Jiaqi, dropped to 150 million yuan from 263 million yuan in the previous year. According to shanghai securities news, the founder of Huaxizi once said in public that their cooperation with Li Jiaqi is Live Delivery 2.0, that is, inviting anchors to create products together. Some insiders revealed: "As long as this product Li Jiaqi says no, it will not pass."

After the eyebrow pencil dispute, Li Jiaqi gradually withdrew

Although Li Jiaqi still has a long way to go to quell doubts and rebuild trust, compared with Hua Xizi who was involved in the storm by his inappropriate remarks, as the starting point of the storm, he seems to have gradually withdrawn from the continuous controversy.

According to previous poster news reports, on September 26th, Li Jiaqi was carrying goods live on Taobao on the night when Hua Xizi’s crazy public relations sparked heated discussion. At the beginning of the storm, a large number of netizens flocked to the live broadcast room in Li Jiaqi to denounce it. Then, there were few questioning voices in the comment area, and the live broadcast room seemed to have returned to its former order. At 21: 42 on September 26th, the poster journalist entered the Taobao live room in Li Jiaqi, when he was carrying lipstick of Mao Geping brand, and the number of viewers in the live room was 7.146 million.

According to the International Finance News, the third season of the self-made variety "All Girls’ OFFER" produced by US ONE arrived as scheduled, showing the process of "negotiation" between Li Jiaqi and major beauty brands, which greatly promoted the upcoming "double 11". Janice (pseudonym), a well-known MCN organization engaged in beauty cosmetics vertical operation, said in an interview with the International Finance News that the Li Jiaqi incident had no impact on her MCN organization. "No matter what, the brand will still come to us for cooperation."

An insider of ONE told reporters that after the incident, the company’s publicity scale during the "double 11" period may be reduced, but "the traffic brought by the live broadcast room in Li Jiaqi is still very large." It is blunt that in the past few years, US ONE has established a large-scale system from product selection to after-sales improvement, and it still has advantages in the field of live e-commerce. "Especially after public relations, the trend of public opinion has become ‘ I don’t care about the anchor, anyway, as a consumer, it is good to buy a cheap and cost-effective product ’ 。” However, in the view of Wang Tian (pseudonym), a business practitioner of a live broadcast room in online celebrity, Tik Tok, if the live broadcast room in Li Jiaqi accounts for a large proportion of the brand’s performance planning of Taobao platform, after the storm, the brand may avoid risks by reducing the frequency of cooperation with Li Jiaqi and increasing the number of people to broadcast. "In the long run, the brand will expand other options besides super anchor. They also have their own plans and will not bet on one person. "

Upstream news is integrated from The Paper, Xinmin Evening News, International Finance News, Red Net, shanghai securities news, etc.

From Chen Kun to Roy and Karry, among the stars who are constantly "harvesting" attention in the entertainment circle, it seems that there is never a lack of Chongqing elements. If it is said that ten years ago, Chen Kun began to impress the audience with his youthful and immature acting skills, it was the beginning of Chongqing children’s journey in the entertainment circle; Then at the dawn of the second decade of the new century, successors have appeared on this long journey …

Needless to say, Roy and Karry, two children who have long been popular all over the country through TFBOYS, Sean Xiao, who won the popularity of the new generation of actors this year, Vin, Ivan and YoRoll , who are the most popular new men’s team at present, followed closely, and J.zen, Gu Landi and other names have repeatedly refreshed your understanding of the newcomers in the entertainment circle. In the next decade, it should be the following new forces that attract your attention and guide your remote control and mouse.

Sean Xiao

The hottest Chinese actor this year

How new is the "new power"? We might as well take the year 2000, the first year of the 21st century, as the base point.

That year, Chen Kun was a student of the Beijing Film Academy. After the movie "National Anthem", he participated in his second drama "Like Fog, Like Rain and Like Wind", but at this time he was just a little coffee hidden behind the highlights of Zhou Xun and Lu Yi. This year, Roy and Vin were born, Karry just turned one year old and YoRoll  and Ivan were two years old. The older ones are J.zen and Gu Landi, who are 5 and 6 years old respectively. Xiao Zhan, who is 9 years old, should start learning piano under the guidance of his father.

Wei Wuxian played by Sean Xiao The Untamed.

In a blink of an eye, 10 years later, they all became "popular fried chicken", and some of them were even hotter than Chen Kun in 2000.

If you want to ask how hot Sean Xiao is now? Just pay a little attention to the frequency of his name appearing in various news information in the last week, and you can perceive one or two. New Year’s Eve and New Year’s Day are approaching. He is on the guest lists of CCTV, Beijing Satellite TV and Oriental TV. Among them, Beijing Satellite TV also chose Sean Xiao as the spokesperson for the 2020 Spring Festival Gala.

Sean Xiao became the spokesperson for the 2020 Beijing Spring Festival Evening.

Not only that, all kinds of "harvest" hot search and attention in Sean Xiao can be described as full bloom. Let’s take a closer look at the variety field. In the music reality show "The Voice of Chinese Dreams Our Songs", which is being broadcasted by Oriental TV, his partner, Tian Na Ying, praised him as "really handsome" from the first sight, and the following two people’s cooperation, "Follow Your Feelings" and "Night at the Naval Port" were hotly debated in every capital.

Sean Xiao has become the "darling" of fashion magazines.

Secondly, magazine covers and photos, which have always been Vogue of the main battlefields for star competition, have ELLE published Sean Xiao’s photos or covers.

In the field of TV series, The Untamed, a costume drama that was popular all over the network in June this year, was regarded as the tipping point of Sean Xiao’s popularity. In the play, his handsome appearance is just in line with the audience’s imagination of Wei, the original character: clean, optimistic and cheerful. On December 20th, Douban made a ranking list from movies to TV series in 2019. The Untamed ranked third in the highest-rated Chinese drama series in 2019 with 8.3 points, and Sean Xiao won the first place among the most watched Chinese actors in 2019.

Sean Xiao in college.

Compared with several Chongqing babies who will be mentioned later in Ran Ran, Sean Xiao is not too young. Born in 1991, he studied painting, violin and other literary specialties under the cultivation of his father since childhood. In 2010, Sean Xiao was admitted to chongqing technology and business university Modern International Design and Art Institute. Since he entered the school, he has been a member of the class’s literary and art committee, and also served as the head of vocal music department and male voice department of the college students’ art troupe, as well as an actor of the school’s language and art sub-group.

In her sophomore year, Sean Xiao, who won the title of "Top Ten Singers on Campus" in chongqing technology and business university, participated in the "Top Ten Singers on Campus" competition in Chongqing on behalf of her school and won the second prize. It is worth mentioning that when he was a student, Sean Xiao also played a lot of tricks in his professional field: in 2012, he and his friend Camera founded the "Recalling Light and Shadow Visual Media" photography studio and the "NED Design Studio", and he was the main photographer and designer.

Until now, Weibo’s name in Sean Xiao still retains the head of his newly-debuted group "X-Nine Youth League". In June 2015, he was invited to participate in Zhejiang Satellite TV’s amateur inspirational program "Burn Boys" and became a trainee. In the finals in February of the following year, although Sean Xiao and his teammates narrowly lost to the Chris Lee team, in September of the same year, they announced their debut as the lead singer of the X-Nine Youth League. Since then, Sean Xiao’s performances in costume dramas "Breaking the Sky" and "Your Highness the Wolf" have been recognized by everyone. In the popular costume drama Joy of Life, although Sean Xiao is a supporting role, the hot discussion expected by netizens has spread all over the network since the first day of the drama.

Up to now, the number of Weibo fans in Sean Xiao has reached a staggering 21 million, and among the more than 700 Weibo posts, the likes of any one easily exceeded 1 million. It is no exaggeration to say that, as Douban commented, he is definitely the first most concerned Chinese actor at present.

The hottest new men’s team "R1SE"

Three of the 11 members are Chongqing children.

R1SE men’s team

On 14th of this month, R1SE, a men’s group, announced that it had been a group debut for less than half a year, put "WE ARE R.1.S.E-2019 R1SE National Tour Concert" into the Chongqing Concert of Chongqing Huaxi International Cultural and Sports Center. The scene is naturally screaming and cheering. This concert is of great significance to the three members of R1SE: Vin, Ivan and Zhang Yanquan are authentic Chongqing babies.

For this reason, R1SE specially designed an interactive session with unique regional characteristics for Chongqing fans. The members not only adapted the lyrics of the song "Deba" into Chongqing dialect "Yaode", but also performed a dialect chorus with the live fans. Combined with Chongqing special hot pot, a creative game "What’s in the hot pot restaurant" was created, which made the concert scene burst into laughter again and again.

Back in June this year, the reality show "Creation Camp 2019" launched by Tencent Video specially selected men’s teams finally scheduled the final seats. According to the program rules, 11 members of the "R1SE" group who made their debut as a group were born. Among the 11 members born after the elimination of 101 trainees, three Chongqing children were included: the names of Vin, Ivan and YoRoll  instantly became popular on the Internet.

Vin

You are not mistaken. After 00, you have already started to board this eye-catching stage. Vin, the third of the three, was born in 2000, while YoRoll  and Yao Chen were both born in 1998. According to Vin’s self-report when he participated in Creation Camp 2019, his idea of going on stage was influenced by Michael Jackson: in 2012, at the age of 12, after watching Michael Jackson’s performance in This is it, he had the idea of going on stage for the first time, and it got out of hand. He first signed up for a street dance class, and then spent two years persuading his parents to let him take the road of acting. Before participating in the domestic draft variety show, he went to an entertainment company in South Korea as a trainee in 2014.

Before this year’s "Creation Camp 2109" won the C place, Vin had already won the fourth place in the 2017 musical idol cultivation program "Son of Tomorrow" and made her debut. Two months ago, Vin was selected into the 2019 Forbes China list of 30 elites under the age of 30 by virtue of her popularity.

Ivan Yao

Ivan, born in 1998, also had the experience of joining a Korean entertainment company as an intern. In "Creation Camp 2019", Yao Chen’s first stage performance of "Baddd" attracted countless attention. During the performance, Ivan inadvertently lifted his T-shirt to reveal eight abdominal muscles, which also made him known as a "small waist" by fans.

YoRoll 

YoRoll  is famous for her "interesting soul" among R1SE members. On the one hand, he keeps making golden sentences in the "Creation Camp 2019" program, such as calling PK among students "mutual torture to the bald head"; On the other hand, the scene of Chongqing Xiaoer, who is super spicy, recommending Laoganma’s hot sauce for other students in the program has also made fans talk about it for a long time.

The scene of YoRoll ‘s crazy recommendation of hot sauce

As he himself said in the program, his interest in rap began in junior high school. "My classmates showed me a rough MV made by a domestic rapper, but the content was very close to life." He immediately fell in love with this form of writing everything that happened around him into a song and began to try originality. Nowadays, family members are very supportive of this road chosen by Zhang Yan. In an interview, he even laughed that his father is his number one male fan. "His ten circle of friends, nine of them are all about me, and I find people everywhere to like me."

J.zen

A cold folded ear root was forwarded by Weibo for more than 240,000 times.

On December 22nd, J.zen’s name was posted on the hot search because Ronghao Li, who had just finished his concert in Chongqing, met Xiao Zhu at the airport and stopped him. At first, he didn’t react. When he recognized that he was Ronghao Li, the music tutor when he participated in the online comprehensive Idol Trainee, J.zen’s appearance as a good student made fans happy instantly.

J.zen

If you don’t know J.zen, it only means that you are either old or Out.

Now logging in to Luneng Bashu Middle School, official website can find J.zen’s name in the classmate record of Class 16, Grade 2012.

J.zen was born in Chongqing in 1994. Until now, if you log in to Luneng Bashu Middle School, official website can find his name in the previous student lists. He is in Class 16, Grade 2012. Compared with Chongqing’s fellow villagers who are equally popular in the entertainment circle today, J.zen is a broader type. He and Variety should have been electrocuted since high school: in 2011, J.zen’s name was included in the second season of China’s Got Talent. Later, he entered Beijing Modern Music Institute to study in university.

The reason why J.zen dabbles in a lot is that he has appeared in the dance competition program, the magic reality show and the most popular variety show "Hip-hop in China" in 2017 (entering the top 46 in China). However, if we really want to say that J.zen’s name is on fire, it is inseparable from the reality show "Idol Trainee" formed by the idol men’s team that was red and purple last year. In this program, J.zen and the current traffic took the PK of KUN, Chen Linong and Adam, and finally ranked 14th. This achievement is quite rare.

This year’s Spring Festival, J.zen’s cold salad is broken.

How hot is J.zen, who has released his second personal music EP "Something Worth mentioning" in April this year? The reporter noticed that the number of his real-name authentication fans in Weibo has already exceeded 6.4 million. As a Chongqing cub, he is naturally unambiguous in eating. Apart from basking in the Vlog that he made "Chongqing tomato scrambled eggs" and "boiled meat slices", this year’s Spring Festival J.zen basked in a picture of himself eating New Year’s Eve dinner at home in Chongqing: "The legendary braised fish of grandma and the broken ears of grandpa’s cold salad". This Weibo has been forwarded more than 240,000 times, and the number of likes has exceeded 78,000 times.

Gulandi

Chongqing guy who won the popularity of "making stars in a new way"

Compared with his peers in other circles, Gu Landi, who was born in Chongqing in 1995, was quite unconventional from his debut to his popularity. Although he also participated in Iqiyi’s talent show "Youth has You", he actually made his debut before this program started: In the online drama "Love You So Sweet" of Tencent video last year, Gu Landi starred in the male No.2.

Gulandi

In January of this year, Youth with You, which has been regarded as the second season of Idol Trainee, was launched, and Gu Landi joined it as a trainee. After two months of competition, Gu Landi regretted stopping in the top 20, and something interesting happened at this time. He, together with Shi Mingze, Hu Wenxuan, Xu Bingchao and Ding Feijun, formed a men’s team named "D5, the fifth son of the desert" and announced his debut. The operation team behind it is Lehua Entertainment, which has previously launched the "NEXT of the Seven sons of Lehua" (the main members include THEO and Adam).

Displaying the Imperial Capital of Valley Blue is a "trainee" from Youth with You.

The key to saying that it is the result of the current "new game of making stars" is that "the fifth son of the desert D5" announced its existence for only three months at the same time from the date of its birth. Not only that, the unique significance of "Five Sons of the Desert D5" is that it is the first case of spontaneous group cooperation between artists from different companies. People in the industry generally believe that this has unlocked the new mode of idol draft, given the eliminated players new opportunities, and maintained the heat of the players after the game to a certain extent. At the same time of forming a group, "Desert Wuzi D5" has an official fan club, and the membership card valid for three months costs 99 yuan.

During the three-month existence of "Five Sons of the Desert D5", they released two singles successively, and they also appeared in the theme concert of "Burning Snow" in the 1000-day countdown to the Beijing Winter Olympics.

Upstream News chongqing morning post Reporter Qiu Jinxi

[Disclaimer] The texts, pictures, audio and video that are not marked with "Source: Upstream News-chongqing morning post" or "Upstream News LOGO" on the upstream news client are all reposted. If the reposted manuscript involves copyright issues, please contact the upstream news.

　　Screenshot of Tik Tok account of "Qinba Grandma Qinba Yiwei". The picture comes from the Internet.

　　In Shengli Community, Jincheng Street, Lin ‘an District, Hangzhou City, Zhejiang Province, young social workers guide the old people how to shop with their mobile phones. Xinhua News Agency reporter Xu Yushe

　　An elderly person is broadcasting live. The picture comes from the Internet.

　　In recent years, more and more middle-aged and elderly people shine brilliantly on the Internet platform. Sending short videos, opening live broadcasts and selling goods online … … They have subverted people’s traditional impression of old age, attracted a large number of fans to watch and become a beautiful landscape in the era of mobile internet.

　　"Silver-haired online celebrity" shows a different style

　　Accompanied by ancient music, four ladies dressed in batik cheongsam are walking leisurely. They are either holding red umbrellas or dancing folding fans, smiling and full of confidence. This is a 15-second short video released by Tik Tok’s account "Fashion Grandma Group", which has received nearly 1.5 million likes. It is hard to imagine that they are a group of "silver-haired online celebrity" with an average age of 68.

　　In Aauto Quicker, Tik Tok, bilibili and other short video platforms, countless "silver online celebrity" are everywhere. For example, Tik Tok’s account "Qinba Grandma Qinba Yiwei" records the rural life of two old people near Daba Mountain. Grandma’s cooking of braised pig’s trotters, potato Baba fried bacon, pulp water and other foods in southern Shaanxi made netizens salivate. At present, the account has gained 2.73 million fans and been praised more than 34 million times; The handsome "Grandpa Beihai" often wears a suit, a hat and a bow tie. His love for life and his spirit of "not being old" make many young people envy him. The short video released by "Grandpa Jigong" begins with "Dear Dolls", telling life experiences and talking about the world in simple language, as kind as grandpa next door; "Grandma Wang who only wears high heels" has a live broadcast with goods, and its sales can reach several million yuan, surpassing many young live broadcasts in online celebrity.

　　In the Internet era of "everyone has a microphone", the elderly are no longer network insulators. They pursue fashion, are confident and enthusiastic, know how to consume and love life, and show a unique style of "the most beautiful is the sunset red".

　　The 45th Statistical Report on Internet Development in China shows that by March 2020, the number of netizens in China reached 904 million, and the number of mobile phone users reached 897 million. Among netizens, netizens aged 50 and above account for 16.9%, and the number exceeds 150 million. The Internet continues to penetrate into middle-aged and elderly people.

　　Perceive the temperature of the years from the live broadcast

　　The reporter found out that the "silver-haired people" who are currently popular on the Internet are mainly divided into three categories: First, they show their young mentality and self-disciplined living habits. They often dress well and maintain a good posture and mental outlook, showing people the "exquisite life" of the elderly. The second is to record fragments of daily life. In the warmth and fun of the old people with their wives, children and grandchildren, netizens can feel the deep affection and see the true temperament of the old people who are childlike, lovely and straightforward. The third is to share life common sense and experience. Such as introducing health knowledge through live broadcast, recording short videos to interpret common scams and warning people how to deal with them.

　　What is the charm of "Silver-haired online celebrity"? Some insiders pointed out that there are three "degrees" advantages in online celebrity, namely, the length of life experience, the width of knowledge and the depth of professional fields. Specifically, the rich life experience and social experience of the elderly are not available to young people. They are well-informed, often thoroughly study their own professional fields, have strong comprehensive ability to deal with problems, and have a unique charm of time precipitation. When they express their little philosophies in life as experienced people, they will give people a sense of reliability and peace of mind.

　　Online celebrity’s old people have resonated with their peers, and at the same time, they have been loved and sought after by a large number of young people. For example, seeing the warm picture of "Grandma Qinba" and her wife taking care of each other, many netizens were envious and said that "this is love, and happiness is included in the plain". Industry analysts pointed out that, by contrast, the videos of Grandpa online celebrity and Grandma online celebrity are more authentic, frank and cordial, arousing many young people’s fond childhood memories, and arousing their yearning for their loved ones, family and affection, which is more penetrating and user-friendly.

　　The "silver hair economy" market is on the rise.

　　In May this year, "I’m Grandma Tian" in online celebrity, Tik Tok opened the first live show with goods, and achieved sales of 1.5 million yuan. Experts pointed out that behind the outbreak of "silver-haired online celebrity" is the rise of the trillion-dollar "silver-haired economy" market.

　　Recently, the China Development Report 2020: Trends and Policies of Population Aging in China issued by China Development Foundation said that by 2022, the population over 65 in China will account for 14% of the total population, realizing the transformation to an aging society. In 2050, the aging in China will reach its peak, and the population over 65 will account for 27.9% of the total population in China. "Silver-haired economy" will become a new growth point to promote the sustainable development of China’s economy in the future aging society.

　　Li Jia, deputy director of Pangu Think Tank Aging Society Research Center, believes that what middle-aged and elderly people need is to find more channels to release their abilities and energy and become participants in social development and progress. As the post-60s with higher education begin to retire, middle-aged and elderly people will be completely separated from the stereotype of "digital refugees" in the past, and their social needs are growing day by day, which is a good opportunity for the market to mature.

　　"Silver-haired online celebrity" not only spreads the positive energy of loving life and attaching importance to family, but also is a blue ocean with infinite opportunities. The insiders believe that the current market consumption potential of "Silver Hair online celebrity" has not been fully tapped, and there is still huge market space. To achieve the economic benefits of "silver-haired online celebrity", we need team packaging and continuous content output. In addition, due to limited energy, the old people are not familiar with the Internet economy and fans’ psychology, and the live broadcast of goods still faces no small challenge.